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TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A et al.. Acta neuropathologica, 2020-08-09
Topic: Brain proteins, microglia and lab models
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2 is expressed by microglia and promotes microglial survival, proliferation, and phagocytic activity.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., et al. (2020). TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. https://doi.org/10.1007/s00401-020-02193-z
Vancouver
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. 2020. doi:10.1007/s00401-020-02193-z. PMID: 32772264.
BibTeX
@article{cignarella2020-32772264,
author = {Cignarella, F. and Filipello, F. and Bollman, B. and Cantoni, C. and Locca, A. and Mikesell, R. and Manis, M. and Ibrahim, A. and others},
title = {{TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis}},
journal = {Acta neuropathologica},
year = {2020},
doi = {10.1007/s00401-020-02193-z},
pmid = {32772264},
url = {https://doi.org/10.1007/s00401-020-02193-z}
}
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Key findings
- Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination.
- TREM2 is expressed by microglia and promotes microglial survival, proliferation, and phagocytic activity.
- Herein we demonstrate that TREM2 was highly expressed on myelin-laden phagocytes in active demyelinating lesions in the CNS of subjects with MS.
- In gene expression studies, macrophages from subjects with TREM2 genetic deficiency displayed a defect in phagocytic pathways.
Why it matters
This study examined TREM2 in myelin debris clearance in multiple sclerosis, not Alzheimer's disease. It does not test any Alzheimer's treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 391 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 48.9 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 5 / 6 | Cited 26.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 20 other studies in this library |
| Still being cited | 4 / 4 | Cited 203 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Laura M. Piccio: h-index 50 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32772264) |
| Free to read | 2 / 2 | Free to read |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00401-020-02193-z
- PubMed: 32772264
- Original source →
- Free full text: Acta Neuropathologica →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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