Newest studies

Alzheimer’s disease diagnosis among dementia patients via blood biomarker measurement based on the AT(N) system

41/100 ✓ Peer-reviewed Cognitive tests and assessment Chinese Medical Journal

Key finding: A total of 156 patients were clinically diagnosed with dementia based on the 2011 NIA-AA criteria, regardless of specific disease etiology, and all exhibited significant brain atrophy on anatomical magnetic resonance imaging (MRI), indicating neuronal injury (N+). +4 more findings

• Diagnosis
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Multimodal magnetic resonance imaging analysis of early mild cognitive impairment

38/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: Significant differences were found between EMCI and AD group in fALFF (right insula) and ReHo (bilateral caudate regions). +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Machine Learning Analysis of Engagement Behaviors in Older Adults With Dementia Playing Mobile Games: Exploratory Study

37/100 ✓ Peer-reviewed Digital health tools JMIR Serious Games

Key finding: Significant differences in 64% of engagement-related behaviors were found between groups, notably in torso movements, voice modulation, facial expressions, and concentration. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Cerebrospinal Fluid Beta-Amyloid Concentration and Clinical and Radiographic Manifestations of Cerebral Amyloid Angiopathy

52/100 ✓ Peer-reviewed Tau biomarkers Journal of the American Heart Association

Key finding: Cerebral amyloid angiopathy (CAA) is driven by vascular Aβ (amyloid-beta) deposition, which can be detected as reduced Aβ species in cerebrospinal fluid (CSF). +3 more findings

• Biomarkers
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries

76/100 ✓ Peer-reviewed Tau biomarkers JAMA network open

Key finding: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). +3 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis

76/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting of elevated β-amyloid (Aβ), but the evidence for sex differences in tau accumulation rates is inconclusive. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Cardiovascular Health and Biomarkers of Neurodegenerative Disease in Older Adults

59/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: These findings suggest that promoting CVH in older adults may help alleviate the burden of neurodegenerative diseases, particularly among Black adults, who are known to experience a higher prevalence of cardiovascular disease. +4 more findings

• Biomarkers
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Physical Activity, Alzheimer Plasma Biomarkers, and Cognition

63/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: These findings suggest that PA may help delay cognitive decline by modulating neurodegeneration and AD-specific tau pathologies. +3 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Multicomponent Intervention for Distressed Informal Caregivers of People With Dementia: A Randomized Clinical Trial

69/100 ✓ Peer-reviewed Caregiving JAMA Network Open

Key finding: The MBI component significantly improved multiple caregiver outcomes, with reduced depressive symptoms (β = -2.13 [95% CI, -2.85 to -1.38]; P Conclusions and relevance In this clinical trial of informal caregivers of people with dementia, synergistic interaction effects were noted for MBI, which enhanced the benefits of SC and BPM on depression. +1 more finding

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Here, we investigated how persistent ISR activation impacts cognitive performance, primarily focusing on a PPP1R15B R658C genetic variant associated with intellectual disability. +4 more findings

• Brain Biology

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities

75/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We emphasize the need for a continuous exploration of tau degradation mechanisms and provide a future perspective for developing tau-targeted degraders, encouraging researchers to work on new treatment options for AD patients. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Associations among sleep quality, sleep duration, and Alzheimer's disease biomarkers: A systematic review and meta-analysis

80/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In total, 30 studies were included comprising 14,997 subjects. +4 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cerebral Amyloid Angiopathy: Clinical Presentation, Sequelae and Neuroimaging Features-An Update

45/100 ✓ Peer-reviewed Treatments Biomedicines

Key finding: Recent findings indicate that treatment should be continued in cases of mild ARIA, with ongoing MRI and clinical monitoring.

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Palliative Care in the Community and the Relevance of Percutaneous Endoscopic Gastrostomy Placement to Quality of Life and Survival

43/100 ✓ Peer-reviewed End-of-life care Journal of dementia and Alzheimer's disease

Key finding: The statistical analysis revealed that the survival time was significantly longer in females compared to males (p = 0.003). +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Alone in the Mind: Review of Research Examining the Link Between Loneliness and Dementia

29/100 ✓ Peer-reviewed Prevention trials Medicine Advances

Key finding: This narrative review focused on research investigating the impact of loneliness on the prevalence of dementia and its relationship with other risk factors. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

The effect of perioperative cognitive training on postoperative delirium in older patients undergoing total hip and knee arthroplasty: a prospective randomised trial

39/100 ✓ Peer-reviewed Prevention trials Age and Ageing

Key finding: In this study, 122 individuals were divided into two groups. +4 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Feasibility and acceptability of a remote computerized cognitive training employing telehealth in older adults with subjective cognitive complaints

49/100 ✓ Peer-reviewed Prevention trials Digital Health

Key finding: A significant improvement in mental flexibility and planning abilities was observed in both groups (as measured by the Zoo planning test), but no other neuropsychological tests showed improvement. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Astrocyte glypican 5 regulates synapse maturation and stabilization

46/100 ✓ Peer-reviewed Inflammation and the immune system Cell Reports

Key finding: We show that astrocytes, through production of glypican 5 (GPC5), are required for maturation and refinement of synapses in the mouse cortex during the critical period. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Structural insights and milestones in TDP-43 research: A comprehensive review of its pathological and therapeutic advances

45/100 ✓ Peer-reviewed Brain tissue and pathology International Journal of Biological Macromolecules

Key finding: This review provides a comprehensive retrospective and prospective analysis of TDP-43 research, highlighting structural insights, significant milestones, and the evolving understanding of its physiological and pathological functions.

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity

49/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

Key finding: The FCAAS-4 achieved a mean area under the receiver operating characteristic curve (AUC-ROC) of 0.74 (95% confidence interval: 0.71-0.77) and a Harrell generalized c-index of 0.72 (0.70-0.75). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma biomarkers distinguish Boston Criteria 2.0 cerebral amyloid angiopathy from healthy controls

45/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

Key finding: Plasma Aβ 42/40 , p‐tau‐181, and NfL differ in those with CAA and together can discriminate CAA from healthy controls. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment

38/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychology

Key finding: The CU- group had lower baseline GAP-43 than all Aβ+ groups, but not the other Aβ- groups. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Statistical Method for Identification of Alzheimer's Disease in Mild Cognitive Impairment with Multimodal Predictive Markers

39/100 ✓ Peer-reviewed Mild cognitive impairment Basic and Clinical Neuroscience Journal

Key finding: Our findings showed the strong predictive potential of PET, particularly florbetaben (FBB), which achieved an AUC of 0.84. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Heterogeneity of cognitive progression and clinical predictors in Parkinson’s disease–subjective cognitive decline

52/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Neurology

Key finding: Subjects with PD-SCD do not consistently show cognitive decline, but rather exhibit a heterogeneous progression. +3 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Parkinsonism in Alzheimer's disease without Lewy bodies in association with nigral neuron loss: A data‐driven clinicopathologic study

46/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Among 635 AD patients without LB, 62 (9.7%) presented parkinsonism, which correlated with reduced nigral neuron density (p < 0.01). +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source