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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Down syndrome and Alzheimer's

Topic: Brain proteins, microglia and lab models

Plain-language summary

Erythrocytes are deeply sensitive cells and important health indicators. During inflammatory response RBC, as a part of haematological system, are exposed to circulating inflammatory mediators and related oxidative stress. They present a highly specialized and organized cell membrane that interacts with inflammatory mediators and oxidative agents, leading to a variety of structural changes that promptly signal an abnormal situation. This review is aimed to provide an overview on erythrocyte involvement in physiological and pathological processes related to oxidative stress, such as aging, Down syndrome, neurodegenerative diseases, for instance Alzheimer Disease, erectile dysfunction and cardiovascular diseases. In particular this review will focus on the effects of oxidative stress on structural changes in the cell membrane and also on in the activity of erythrocyte enzymes such as membrane-bound, cytosolic glycohydrolases and RBC-eNOS. This review also underlines the potential clinical application of erythrocyte specific related parameters, which can be important tools not only for the study but also for the monitoring of several oxidative stress related diseases.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Massaccesi, L., Galliera, E., & Corsi Romanelli, M. M. (2020). Erythrocytes as markers of oxidative stress related pathologies. Mechanisms of ageing and development. https://doi.org/10.1016/j.mad.2020.111333

Vancouver

Massaccesi L, Galliera E, Corsi Romanelli MM. Erythrocytes as markers of oxidative stress related pathologies. Mechanisms of ageing and development. 2020. doi:10.1016/j.mad.2020.111333. PMID: 32814082.

BibTeX

@article{massaccesi2020-32814082,
  author  = {Massaccesi, L. and Galliera, E. and Corsi Romanelli, M. M.},
  title   = {{Erythrocytes as markers of oxidative stress related pathologies}},
  journal = {Mechanisms of ageing and development},
  year    = {2020},
  doi     = {10.1016/j.mad.2020.111333},
  pmid    = {32814082},
  url     = {https://doi.org/10.1016/j.mad.2020.111333}
}

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How to read this study

Design: this is a narrative review. It summarises a field without a fixed search method, so it shows how authors read the evidence rather than measuring it. Use it to find the primary studies, not as a result in itself.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

During inflammatory response RBC, as a part of haematological system, are exposed to circulating inflammatory mediators and related oxidative stress.
They present a highly specialized and organized cell membrane that interacts with inflammatory mediators and oxidative agents, leading to a variety of structural changes that promptly signal an abnormal situation.
This review is aimed to provide an overview on erythrocyte involvement in physiological and pathological processes related to oxidative stress, such as aging, Down syndrome, neurodegenerative diseases, for instance Alzheimer Disease, erectile dysfunction and cardiovascular diseases.
In particular this review will focus on the effects of oxidative stress on structural changes in the cell membrane and also on in the activity of erythrocyte enzymes such as membrane-bound, cytosolic glycohydrolases and RBC-eNOS.
This review also underlines the potential clinical application of erythrocyte specific related parameters, which can be important tools not only for the study but also for the monitoring of several oxidative stress related diseases.

Why it matters

This review describes how red blood cells are affected by oxidative stress and how their membrane changes and enzyme activity might be measured in conditions including Alzheimer's disease. It proposes these red blood cell measures as possible tools for studying and monitoring oxidative stress related diseases, but reports no treatment or cure.

Study details

Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Mechanisms of ageing and development)
Journal's citation record	2 / 4	Mechanisms of Ageing and Development: journal h-index 172 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 57 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.1 citations a year over 8 year(s) since 2020
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 39 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Massimiliano Marco Corsi Romanelli: h-index 42 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Milan: institution h-index 1,023 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32814082)
Free to read	0 / 2	Behind a paywall — scores zero
Total	38 / 100	—

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