Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,326–11,350 of 27,380 studies, newest first · page 454 of 1096.
August 2020 25
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2020-08-06
Global Brain Involvement in Posterior Cortical Atrophy: Multimodal MR Imaging Investigation
39/100 ✓ Peer-reviewed Brain scans and imaging Brain topography
Key finding: The visual network-related areas showed reduced connectivity and was correlated to atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-06
AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State
48/100 ✓ Peer-reviewed Tau biomarkers Journal of geriatric psychiatry and neurology
Key finding: In the total sample, T-tau and Aβ42/p-tau correlated with the total CAMCOG (P < .01); all biomarkers correlated with memory (P < .001); T-tau correlated with language (P < .01). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-05
Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents
70/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: The overall frequency of LATE-NC in Black and White decedents was similar (40.8% vs 45.4%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-05
APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans
39/100 ✓ Peer-reviewed Genetics G3 (Bethesda, Md.)
Key finding: Compared to the other variants (APOE2 and APOE3), the ε4 allele of APOE (APOE4) hastens and exacerbates early and late onset forms of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-05
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population
71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: SORL1 is associated with AD in the Hong Kong Chinese population. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-04
Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging
52/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: Compared to those without LATE-NC or ADNC, those with pure LATE-NC had a faster decline in global cognition (p = 0.025) and episodic memory (p = 0.002); however, compared to persons with pure ADNC, those with pure LATE-NC showed a slower decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-04
Senolytic drugs: from discovery to translation
41/100 ✓ Peer-reviewed Brain scans and imaging Journal of internal medicine
Key finding: In preclinical models, senolytics delay, prevent or alleviate frailty, cancers and cardiovascular, neuropsychiatric, liver, kidney, musculoskeletal, lung, eye, haematological, metabolic and skin disorders as well as complications of organ transplantation, radiation and cancer treatment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-04
Predicting Alzheimer's disease progression using deep recurrent neural networks
65/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage
Key finding: In this study, given multimodal AD markers and clinical diagnosis of an individual from one or more timepoints, we seek to predict the clinical diagnosis, cognition and ventricular volume of the individual for every month (indefinitely) into the future. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-03
From monomer to fibril: Abeta‐amyloid binding to Aducanumab antibody studied by molecular dynamics simulation
38/100 ✓ Peer-reviewed Treatments Proteins: Structure, Function, and Bioinformatics
Key finding: In order to better understand how Aducanumab interacts with aggregated A β ‐forms compared to monomers, we have generated structural model complexes based on the known structure of Aducanumab in complex with an A β 2 − 7 ‐eptitope. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-03
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
39/100 ✓ Peer-reviewed Risk factors The Journal of clinical investigation
Key finding: Diabetes, obesity, and Alzheimer's disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-03
MicroRNA predicts cognitive performance in healthy older adults
39/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: A random forest regression combining miRNA with biological (brain volume), clinical (comorbid conditions), and demographic variables in 115 typically aging older adults explained the greatest level of variance in cognitive performance compared to the other machine learning models explored. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-03
The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology
69/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: This represents the largest U.S.-based, multi-site, biomarker initiative of AD in DS.
Full summary, score breakdown and related studies → Original source
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2020-08-03
Understanding Medicare: Hearing Loss and Health Literacy
54/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Medicare beneficiaries with a little or a lot of trouble hearing had 18% (95% confidence interval [CI] odds ratio [OR] = 1.10-1.27) and 25% (95% CI OR = 1.07-1.47) increased odds of reporting greater difficulty with understanding Medicare, respectively, compared with those with no hearing trouble. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-03
Evaluation of Racial Disparities in Hospice Use and End-of-Life Treatment Intensity in the REGARDS Cohort
69/100 ✓ Peer-reviewed Disparities JAMA network open
Key finding: Black decedents were less likely than White decedents to use hospice for 3 or more days (132 of 378 [34.9%] vs 385 of 834 [46.2%]; P Conclusions and relevance Despite the increase in the use of hospice care in recent decades, racial disparities in the use of hospice remain, especially for noncancer deaths.
Full summary, score breakdown and related studies → Original source
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2020-08-03
Prevention and Management of Delirium in the Intensive Care Unit
48/100 ✓ Peer-reviewed Prevention and risk Seminars in respiratory and critical care medicine
Key finding: It is associated with increased morbidity and mortality, longer lengths of stay, higher hospital costs, and cognitive impairment that persists long after hospital discharge.
Full summary, score breakdown and related studies → Original source
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2020-08-02
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics
38/100 ✓ Peer-reviewed Drug development Biochemical pharmacology
Key finding: The non-acylated and non-PEGylated IRAs (exendin-4, lixisenatide, Peptide 17, DA3-CH and DA-JC4) had significant rates of blood-to-brain influx (Ki), but the acylated IRAs (liraglutide, semaglutide, and Peptide 18) did not measurably cross the BBB.
Full summary, score breakdown and related studies → Original source
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2020-08 month only
A systematic review of the integration of palliative care in dementia management
68/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: Four key themes were identified in this review: goals of care and end-of-life conversations, symptom management, emergency room visits, and prescribing behavior. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Applying the Health Belief Model to Quantify and Investigate Expectations for Computerized Cognitive Training
50/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of cognitive enhancement : towards the integration of theory and practice
Key finding: Despite the demonstrated benefits of computerized cognitive training for older adults, little is known about the determinants of training behavior. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
The Microbiome as a Modifier of Neurodegenerative Disease Risk
38/100 ✓ Peer-reviewed Disease mechanisms Cell host & microbe
Key finding: In this review, we discuss roles for the microbiome in aging and in NDs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
41/100 ✓ Peer-reviewed Drug development BMC complementary medicine and therapies
Key finding: Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-01
Genetic variants and functional pathways associated with resilience to Alzheimer's disease
71/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology
Key finding: As expected, all resilience metrics were genetically correlated with cognitive performance and education attainment traits (P-values < 2.5 × 10-20), and we observed novel correlations with neuropsychiatric conditions (P-values < 7.9 × 10-4). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Early integration of palliative care in a long-term care home: A telemedicine feasibility pilot study
45/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care
Key finding: For the 61 residents, the average age of the residents was 87 years, with 61% being female and 69% having dementia as the primary diagnosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Advance Care Planning Video Intervention Among Long-Stay Nursing Home Residents: A Pragmatic Cluster Randomized Clinical Trial
83/100 ✓ Peer-reviewed End-of-life care JAMA internal medicine
Key finding: There was no significant reduction in hospital transfers per 1000 person-days alive in the intervention vs control groups (rate [SE], 3.7 [0.2]; 95% CI, 3.4-4.0 vs 3.9 [0.3]; 95% CI, 3.6-4.1; rate difference [SE], -0.2 [0.3]; 95% CI, -0.5 to 0.2). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Cognitive training interventions and depression in mild cognitive impairment and dementia: a systematic review and meta-analysis of randomized controlled trials
76/100 ✓ Peer-reviewed Prevention trials Age and ageing
Key finding: Cognitive training interventions show to be a potential treatment to ameliorate depression in people with cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-01
Is Being Home Good for Your Health? Outcomes of Medicaid Home‐ and Community‐Based Long‐Term Care Relative to Nursing Home Care
45/100 ✓ Peer-reviewed Risk factors Health Services Research
Key finding: We combine the MAX data with Medicare claims to identify hospital admissions, our main outcome variable, and with state and county data on the percent of individuals receiving HCBS versus nursing home care. +2 more findings
Full summary, score breakdown and related studies → Original source
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