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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,176–10,200 of 27,380 studies, newest first · page 408 of 1096.

May 2021 25

  1. 2021-05-27

    Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)

    ✓ Peer-reviewed How common it is Alzheimer s & Dementia

    The number of people with clinical AD will increase as the "baby boom" generation reaches older ages, exerting a strong upward influence on disease burden.

    Full summary, score breakdown and related studies → Original source

  2. 2021-05-27

    A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy

    Key finding: At randomization, the mean age is 72, 50% female, 77% with CDR-global score 0.5, and mean MMSE score 23.8. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-05-27

    Recent developments of HDAC inhibitors: Emerging indications and novel molecules

    ✓ Peer-reviewed Lewy body dementia British journal of clinical pharmacology

    Key finding: We found haematologic neoplasms continue to represent the majority of clinical indications for this class of drugs; however, it is clear that there is an ongoing trend towards diversification. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-05-27

    Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

    ✓ Peer-reviewed Brain scans and imaging PLoS medicine

    Key finding: We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-05-26

    Mobile Phone Use and Cognitive Impairment among Elderly Chinese: A National Cross-Sectional Survey Study

    ✓ Peer-reviewed Cognitive tests and assessment International journal of environmental research and public health

    Key finding: The prevalence of cognitive impairment in non-users of mobile phone, dumbphone users, and smartphone users were 17.8%, 5.0%, and 1.4%, respectively. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-05-26

    A community-based computerised cognitive training program for older persons with mild dementia: A pilot study

    ✓ Peer-reviewed Cognitive tests and assessment Australasian journal on ageing

    Key finding: Participants in the experimental group had better overall subjective memory, subjective retrospective memory and global quality of life, with fewer depressive symptoms than those in the control group 3 months following the program. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-05-26

    NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data

    ✓ Peer-reviewed TREM2 and immune genetics Communications biology

    Key finding: For differential expression analysis in multi-subject single-cell data, negative binomial mixed models account for both subject-level and cell-level overdispersions, but are computationally demanding. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-05-25

    Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction

    ✓ Peer-reviewed Vascular contributions Neurochemistry international

    Key finding: Accumulating evidence demonstrated the clinicopathological discrepancies of CMBs, the clinical significance of CMBs associated with other MRI markers of cerebral small vessel disease, cognitive impairments, serum, and cerebrospinal fluid biomarkers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2021-05-25

    Measurement batch differences and between-batch conversion of Alzheimer's disease cerebrospinal fluid biomarker values

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: We found statistically significant batch differences for all biomarkers and ratios, except that neurofilament light was comparable between batches 1 and 2. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-05-25

    Alzheimer's disease drug development pipeline: 2021

    ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)

    Key finding: This pipeline analysis shows that target biological processes are more diversified, biomarkers are more regularly used, and repurposed agents are being explored to determine their utility for the treatment of AD.

    Full summary, score breakdown and related studies → Original source

  11. 2021-05-25

    Geographical Variability in Mortality in Urban Areas: A Joint Analysis of 16 Causes of Death

    ✓ Peer-reviewed Risk factors International Journal of Environmental Research and Public Health

    Key finding: We perform an overall study of 16 causes of death, considering that their geographical patterns could be dependent and estimating the dependence between the causes of death. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2021-05-25

    Cortical Thickness from MRI to Predict Conversion from Mild Cognitive Impairment to Dementia in Parkinson Disease: A Machine Learning-based Model

    ✓ Peer-reviewed Digital health tools Radiology

    Key finding: Cortical thickness from MRI helped predict conversion from mild cognitive impairment to dementia in Parkinson disease at an individual level, with improved performance when integrated with clinical variables. © RSNA, 2021 Online supplemental material is available for this article. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2021-05-24

    Antimuscarinic Cascade Across Individual Cholinesterase Inhibitors in Older Adults with Dementia

    ✓ Peer-reviewed Treatments Drugs & aging

    Key finding: The study included 47,059 older adults with dementia who were incident users of AChEIs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-05-24

    Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β

    ✓ Peer-reviewed Genetics Biochimica et biophysica acta. Molecular and cell biology of lipids

    Key finding: Since the identification of the apolipoprotein E (apoE) *ε4 allele as a major genetic risk factor for late-onset Alzheimer's disease, significant efforts have been aimed at elucidating how apoE4 expression confers greater brain amyloid-β (Aβ) burden, earlier disease onset and worse clinical outcomes compared to apoE2 and apoE3.

    Full summary, score breakdown and related studies → Original source

  15. 2021-05-24

    Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures

    ✓ Peer-reviewed Mild cognitive impairment Nature medicine

    Key finding: Using cerebrospinal fluid P-tau, Aβ42/Aβ40 and neurofilament light instead of plasma biomarkers did not improve the accuracy significantly. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2021-05-24

    Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: One hundred forty-six participants were examined (age 72 ± 6 years). +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-05-21

    Proteolytic α-Synuclein Cleavage in Health and Disease

    ✓ Peer-reviewed Brain tissue and pathology International journal of molecular sciences

    Key finding: Recent evidence indicates that oxidative stress induced by metal ions and post-translational modifications such as phosphorylation, ubiquitination, nitration, glycation, and SUMOylation affect α-synuclein conformation along with its aggregation propensity and neurotoxic profiles. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2021-05-21

    Transcriptional signature in microglia associated with Aβ plaque phagocytosis

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: XO4 + microglial transcriptomes demonstrated dysregulated expression of genes associated with late onset AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-05-21

    Using data linkage for national surveillance of clinical quality indicators for dementia care among Australian aged care users

    ✓ Peer-reviewed Risk factors Scientific Reports

    Key finding: Existing strategies to improve national performance on these indicators appear to be insufficient, despite the significant impact of these indicators on outcomes for people with dementia.

    Full summary, score breakdown and related studies → Original source

  20. 2021-05-20

    Advance care planning among Medicare beneficiaries with dementia undergoing surgery

    ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

    Key finding: ACP billing codes from 6 months before to 6 months after admission for inpatient surgery. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-05-20

    Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies

    ✓ Peer-reviewed Drug development Translational neurodegeneration

    Key finding: The resultant neurodegenerative diseases are a large group of disorders defined by a gradual loss of neurons and a progressive impairment in neuronal function. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-05-20

    Impact of a regimen-level prior authorization tool on provider adherence to clinical guidelines’ and cost savings in a Medicare advantage population

    ✓ Peer-reviewed Health systems and care delivery Journal of Clinical Oncology

    Key finding: From April-December 2020, 279 PAs were submitted via NLX and 83% were automatically approved in real-time. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-05-20

    Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

    ✓ Peer-reviewed TREM2 and immune genetics Cell

    Key finding: To assemble a comprehensive ccRCC tumor microenvironment (TME) atlas, we performed single-cell RNA sequencing (scRNA-seq) of hematopoietic and non-hematopoietic subpopulations from tumor and tumor-adjacent tissue of treatment-naive ccRCC resections. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-05-20

    Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease

    ✓ Peer-reviewed Prevention and risk Frontiers in endocrinology

    Key finding: Increasing evidence indicates that physical activity and exercise training may delay or prevent the onset of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-05-20

    Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Neither fibrillar nor nonfibrillar Aβ content alone sufficed to explain the Aβ PET findings in either AD model. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →