Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 10,201–10,225 of 27,380 studies, newest first · page 409 of 1096.
May 2021 25
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2021-05-19
Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition
41/100 ✓ Peer-reviewed Drug development Biochemistry
Key finding: Recent structural studies have shown that the tau filaments isolated from different neurodegenerative disorders have structurally distinct fibril cores that are specific to the disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-19
Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers
41/100 ✓ Peer-reviewed Genetics Translational psychiatry
Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-19
Geographic disparities in mortality from Alzheimer's disease and related dementias
44/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: The county clusters with the highest and lowest AD mortality rates were in Washington (WA) and New York (NY), respectively, with other notable high-mortality clusters on the border of Tennessee, Georgia, and Alabama as well as in North Dakota and South Dakota. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-19
Sex differences in the association between major cardiovascular risk factors in midlife and dementia: a cohort study using data from the UK Biobank
64/100 ✓ Peer-reviewed Long-term cohort studies BMC medicine
Key finding: Sex differences in major cardiovascular risk factors for incident (fatal or non-fatal) all-cause dementia were assessed in the UK Biobank. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-18
Hearing Impairment and Cognition in an Aging World
41/100 ✓ Peer-reviewed Risk factors Journal of the Association for Research in Otolaryngology : JARO
Key finding: With the increasing number of older adults around the world, the overall number of dementia cases is expected to rise dramatically in the next 40 years. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-18
Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia
57/100 ✓ Peer-reviewed Brain scans and imaging Journal of magnetic resonance imaging : JMRI
Key finding: Our results showed HP was functionally divided into HPhead , HPbody , and HPtail bilaterally along the longitudinal axis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-18
P-tau/Aβ42 and Aβ42/40 ratios in CSF are equally predictive of amyloid PET status
55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: These data suggest that p-tau/Aβ42 and Aβ42/40 ratios provide similar clinical information in the assessment of amyloid pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-18
A neurologist's perspective on serum neurofilament light in the memory clinic: a prospective implementation study
43/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: SNfL was perceived as useful in 53% (n = 58) of the cases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-17
Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer's Disease
41/100 ✓ Peer-reviewed Drug development ACS applied materials & interfaces
Key finding: The aggregation of tau exerts neurotoxicity, and its spreading in the brain is associated with increasing severity of clinical symptoms for AD patients; thus tau-targeting therapies hold great potential against AD.
Full summary, score breakdown and related studies → Original source
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2021-05-17
Ocular biomarkers and their role in the early diagnosis of neurocognitive disorders
41/100 ✓ Peer-reviewed Brain scans and imaging European journal of ophthalmology
Key finding: Since the introduction of the non-invasive optical coherence tomography (OCT) and the newly developed modality OCT-angiography (OCT-A) that can demonstrate the structure and the microvasculature of the retina and choroid, respectively, there have been promising results regarding the value of the ophthalmologic examination in the early diagnosis of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2021-05-17
The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis
43/100 ✓ Peer-reviewed Biomarkers Clinica chimica acta; international journal of clinical chemistry
Key finding: The PrecivityAD™ assays are precise, accurate, sensitive, and linear over a wide analytical range, free from significant interferences, and suitable for use in the clinical laboratory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-16
Virtual Reality-Based Cognitive Stimulation on People with Mild to Moderate Dementia due to Alzheimer's Disease: A Pilot Randomized Controlled Trial
77/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of environmental research and public health
Key finding: However, the results of such an approach on dementia caused by Alzheimer's disease (AD) are still lacking. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-05-14
Dementia Incidence, Burden and Cost of Care: A Filipino Community-Based Study
82/100 ✓ Peer-reviewed Costs and economics Frontiers in public health
Key finding: The crude incidence rate was 16 (CI: 13-20) cases per 1,000 person-years (pyr) with 17 (CI: 12-21) per 1,000 pyr for females and 14 (CI: 9-21) per 1,000 pyr for males. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-14
TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels
45/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We identify novel genome-wide significant associations between DNA variants in TMEM106B and CSF levels of NfL, and between CPOX and YKL-40. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-14
MIND diet and cognitive performance in older adults: a systematic review
67/100 ✓ Peer-reviewed Prevention trials Critical reviews in food science and nutrition
Key finding: All of the included studies indicated that adherence to the MIND diet was positively associated with specific domains, but not all, of cognition and global cognitive function (78% of the studies) in older adults. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-05-14
Dying with dementia in Medicare Advantage, Accountable Care Organizations, or traditional Medicare
53/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Among 370,094 persons with dementia, 93,801 (25.4%) were in MA (mean age [SD], 86.9 [7.7], 67.6% female), 39,586 (10.7%) were ACO attributed (mean age [SD], 87.2 [7.6], 67.3% female), and 236,707 (63.9%) were in TM (mean age [SD], 87.0 [7.8], 67.6% female). +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-14
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
63/100 ✓ Peer-reviewed Brain tissue and pathology Nature aging
Key finding: We quantified 4,877 plasma proteins in nondemented older adults in the Atherosclerosis Risk in Communities cohort and performed a proteome-wide association study of dementia risk over five years (n = 4,110; 428 incident cases). +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-14
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia
60/100 ✓ Peer-reviewed Caregiving The American journal of psychiatry
Key finding: Anticholinergic medication burden in schizophrenia is substantial, common, conferred by multiple medication classes, and associated with cognitive impairments across all cognitive domains. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-14
Effects of comprehensive intervention on life quality among the elderly with Alzheimer Disease and their caregivers based on mixed models
56/100 ✓ Peer-reviewed Treatments Nursing open
Key finding: The multi-sectoral collaborative care model proposed in this study integrated resources from several departments, effectively improved the quality of life of patients and their caregivers, and provided a way of care services for patients with Alzheimer Disease.
Full summary, score breakdown and related studies → Original source
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2021-05-13
Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer's Disease
41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience
Key finding: Although, early cognitive deficits have been associated with synaptic loss and dysfunction caused by amyloid-β peptides (Aβ), accumulating evidences support a role of astrocytes in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-05-13
Infratentorial pathology in frontotemporal dementia: cerebellar grey and white matter alterations in FTD phenotypes
41/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology
Key finding: Significant cortical thickness reductions were identified in: lobule VII and crus I in bvFTD; lobule VI VII, crus I and II in nfvPPA; and lobule VII, crus I and II in svPPA; lobule IV, VI, VII and Crus I and II in C9 + ALSFTD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-13
Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults
45/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We observed a significant CSF Aβ42 /Aβ40 × p-tau interaction on cortical neurite density index (NDI), but not orientation dispersion index or cortical thickness. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-13
Cognitive Impairment in Parkinson's Disease: Epidemiology, Clinical Profile, Protective and Risk Factors
43/100 ✓ Peer-reviewed Prevention trials Behavioral sciences (Basel, Switzerland)
Key finding: Less is known about protective factors, although the Mediterranean diet and exercise may fall in this category. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-13
Alzheimer disease
60/100 ✓ Peer-reviewed Disease mechanisms Nature Reviews Disease Primers
Key finding: Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing plaques and tau-containing neurofibrillary tangles. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-05-13
Risk factors for severity of COVID-19: a rapid review to inform vaccine prioritisation in Canada
43/100 ✓ Peer-reviewed Disparities BMJ open
Key finding: Increasing age (especially >60 years) may be the most important risk factor for severe outcomes. +1 more finding
Full summary, score breakdown and related studies → Original source
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