Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 9,926–9,950 of 27,380 studies, newest first · page 398 of 1096.
August 2021 25
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2021-08-05
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
50/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: The degree of PVS significantly increased with age in both, BG and CS regions independently of cardiovascular risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-05
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease
55/100 ✓ Peer-reviewed Biomarkers Scientific reports
Key finding: In conclusion, we have developed a novel, noninvasive diagnostic and predictive assay for AD, MCI and PE.
Full summary, score breakdown and related studies → Original source
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2021-08-05
Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition
43/100 ✓ Peer-reviewed Prevention trials Frontiers in nutrition
Key finding: Many studies have associated the Mediterranean diet with a decreased risk of dementia and AD, but a cause-and-effect relationship has not been deduced. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-08-05
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
52/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications
Key finding: We found no association between Braak stage and cognitive impairment when controlling for age (p = 0.76). +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-04
BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
41/100 ✓ Peer-reviewed Inflammation and the immune system iScience
Key finding: BAD pro-apoptotic activity is significantly increased in neurons of AD patients and 5XFAD mice. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-08-04
Fine Particulate Matter and Dementia Incidence in the Adult Changes in Thought Study
68/100 ✓ Peer-reviewed Risk factors Environmental health perspectives
Key finding: We report 1,136 cases of incident dementia among 4,166 individuals with nonmissing APOE status. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-03
Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2
59/100 ✓ Peer-reviewed Digital health tools The Lancet. Child & adolescent health
Key finding: Illness duration and symptom prevalence, duration, and burden were analysed for children testing positive for SARS-CoV-2 for whom illness duration could be determined, and were assessed overall and for younger (age 5-11 years) and older (age 12-17 years) groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-03
The Humanoid Robot Sil-Bot in a Cognitive Training Program for Community-Dwelling Elderly People with Mild Cognitive Impairment during the COVID-19 Pandemic: A Randomized Controlled Trial
78/100 ✓ Peer-reviewed Prevention trials International journal of environmental research and public health
Key finding: A 6-week robot-assisted, multi-domain cognitive training program can improve the efficiency of global cognitive function and depression during cognitive tasks in older adults with MCI, which is associated with improvements in memory and executive function. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-08-02
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?
39/100 ✓ Peer-reviewed Treatments EMBO Molecular Medicine
Key finding: On 7 June , the FDA approved aducanumab, the first new drug for Alzheimer’s disease in almost 20 years—and notably, the first drug with a putative disease‐modifying mechanism for the treatment of this devastating disorder, namely the removal of β‐amyloid (or Aβ) plaques from the brain.
Full summary, score breakdown and related studies → Original source
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2021-08-02
Association Between Dementia Care Programs in Assisted Living Facilities and Transitions to Nursing Homes in Ontario, Canada: A Population-Based Cohort Study
66/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association
Key finding: There were 11.8 transitions to a nursing home per 100 person-years among older adults who resided in an assisted living facility with a dementia care program, compared with 20.5 transitions to a nursing home per 100 person-years among older adults who resided in an assisted living facility without a dementia care program. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-02
MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology
41/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology
Key finding: Individuals with AD had high CSF pT217/T217 and low Aβ42/40. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-02
Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure
43/100 ✓ Peer-reviewed Digital health tools Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Key finding: Because the blood-brain barrier (BBB) leakage is a well-known risk factor for AD, brain organoids are exposed to human serum to mimic the serum exposure consequence of BBB breakdown in AD patient brains. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-02
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies
61/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-02
Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample
61/100 ✓ Peer-reviewed Tau biomarkers JAMA network open
Key finding: New technology is convenient for measuring blood total tau concentrations and provides a unique and increased opportunity for early intervention to slow cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08 month only
The Gut-Brain Axis: Literature Overview and Psychiatric Applications
41/100 ✓ Peer-reviewed Disease mechanisms Federal practitioner : for the health care professionals of the VA, DoD, and PHS
Key finding: Clinicians are encouraged to consider patients' gut health when evaluating and treating psychiatric conditions, such as anxiety and depression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-08 month only
[Post-stroke cognitive deficits and dementia]
41/100 ✓ Peer-reviewed Risk factors Therapeutische Umschau. Revue therapeutique
Key finding: An overall model sufficiently predicting post-stroke cognitive outcome was therefore missing until now. +2 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-01
Aducanumab: First Approval
40/100 ✓ Peer-reviewed Treatments Drugs
Key finding: According to the US FDA prescribing information, treatment should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-01
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease
52/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: For autosomal dominant Alzheimer's disease, we found higher functional MRI-assessed system segregation to be associated with an attenuated effect of estimated years from symptom onset on global cognition (P = 0.007). +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-01
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
58/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: Early-onset Alzheimer's disease, defined as manifesting before age 65, is viewed as a relatively pure form of Alzheimer's disease with a more homogeneous neuropathological substrate. +3 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-01
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
55/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies.
Full summary, score breakdown and related studies → Original source
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2021-08-01
Dementia Diagnosis Disparities by Race and Ethnicity
67/100 ✓ Peer-reviewed Disparities Medical care
Key finding: When diagnosed, non-Hispanic Blacks and Hispanics may have more advanced dementia.
Full summary, score breakdown and related studies → Original source
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2021-08-01
Head-to-head comparison of cerebral blood flow single-photon emission computed tomography and 18 F-fluoro-2-deoxyglucose positron emission tomography in the diagnosis of Alzheimer disease
45/100 ✓ Peer-reviewed Biomarkers Internal medicine journal
Key finding: Clinicians reported high diagnostic confidence in 83% of 18 F-FDG PET compared to 67% for CBF-SPECT (P = 0.001). +1 more finding
Full summary, score breakdown and related studies → Original source
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2021-08-01
Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study
62/100 ✓ Peer-reviewed Biomarkers The Lancet. Neurology
Key finding: Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increased life expectancy compared with adults with Down syndrome in the past.
Full summary, score breakdown and related studies → Original source
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2021-08-01
Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome
64/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Previous studies have suggested that the APOE ɛ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. +4 more findings
Full summary, score breakdown and related studies → Original source
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2021-08-01
Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging
77/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Among 1431 participants, the mean (SD) age was 71.2 (8.8) years; 751 (52.5%) were male. +1 more finding
Full summary, score breakdown and related studies → Original source
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