Newest studies

Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins

44/100 ✓ Peer-reviewed Tau biomarkers Clinical chemistry

Key finding: Cerebrospinal fluid (CSF) concentrations of amyloid beta(42) (Abeta(42)) peptides and tau proteins may serve as biomarkers for Alzheimer disease (AD). +3 more findings

• Brain Biology
• Biomarkers
• Digital Tools

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The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychiatry research

Key finding: The results show that larger hippocampal volume was associated with a significantly stronger cortisol increase in response to the TSST and a significantly greater CRA. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry

Key finding: Here, we provide evidence that genetic variants of the genes encoding PACAP and its receptor, PAC1, are associated with schizophrenia. +2 more findings

• Genetics

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Forensic issues in Down syndrome fatalities

30/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of forensic and legal medicine

Key finding: Down syndrome, or trisomy 21, is the most common chromosomal abnormality associated with intellectual impairment.

• Down Syndrome

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Subjective memory complaints, education, and risk of Alzheimer's disease

61/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Although memory complaints are associated with an increased risk of Alzheimer's disease in persons with cognitive impairment as well as in persons with normal cognition, they are commonly considered of less importance than objective cognitive measures. +3 more findings

• Risk Factors

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Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

36/100 ✓ Peer-reviewed Brain scans and imaging Neuroscience letters

Key finding: The results show that RNFL thickness is statistically reduced in patients with MCI, mild AD or moderate to severe AD compared to controls. +1 more finding

• Early Stage

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Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol

47/100 ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry

Key finding: The 5-HTT s allele was associated with both significantly lower delayed recall and higher waking cortisol levels. +4 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

The endocannabinoid system in targeting inflammatory neurodegenerative diseases

36/100 ✓ Peer-reviewed Inflammation and the immune system Trends in pharmacological sciences

Key finding: The classical divide between degenerative and inflammatory disorders of the CNS is vanishing as accumulating evidence shows that inflammatory processes are important in the pathophysiology of primarily degenerative disorders, and neurodegeneration complicates primarily inflammatory diseases of the brain and spinal cord. +4 more findings

• Brain Biology

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Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia

56/100 ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

Key finding: Compared to cognitively normal subjects, Alzheimer's disease patients had a thinner cortex primarily in bilateral, frontal, parietal, temporal and occipital lobes (P < 0.001), while FTD patients had a thinner cortex in bilateral, frontal and temporal regions and some thinning in inferior parietal regions and the posterior cingulate (P < 0.001). +4 more findings

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

59/100 ✓ Peer-reviewed Inflammation and the immune system Nature medicine

Key finding: In Alzheimer disease, these brain mononuclear phagocytes are recruited from the blood and accumulate in senile plaques. +3 more findings

• Brain Biology

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Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease

46/100 ✓ Peer-reviewed Mild cognitive impairment Brain research

Key finding: In the present study, we measured the level of total protein nitration to determine if excess protein nitration occurs in brain samples from subjects with MCI compared to that in healthy controls. +3 more findings

• Early Stage

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Development of a brief scale of everyday functioning in persons with serious mental illness

50/100 ✓ Peer-reviewed Getting a diagnosis Schizophrenia bulletin

Key finding: UPSA-Brief scores were highly correlated with scores on the full version of the UPSA (r = .91), with overall cognitive functioning (r = .57), and with negative symptoms (r = -.32). +2 more findings

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[Palliative care in dementia and the dismantling of the treatment function of nursing homes]

38/100 ✓ Peer-reviewed Health systems and care delivery Tijdschrift voor gerontologie en geriatrie

Key finding: This definition is not adequate to orient and direct palliative care policies in non-cancer diseases such as dementia. +4 more findings

• Care Services
• End-of-Life Care
• Treatments

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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia

36/100 ✓ Peer-reviewed Clinical safety The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Several investigators have thus examined whether general anesthesia is associated with AD, with some studies suggesting that exposure to anesthetics may increase the risk of AD. +3 more findings

• Brain Biology

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We conclude that soluble, low-n oligomers of human Abeta trigger synapse loss that can be reversed by therapeutic agents.

• Brain Biology

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Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study

55/100 ✓ Peer-reviewed Risk factors Occupational and environmental medicine

Key finding: The association of pesticide exposure with Parkinson's disease suggests a causative role. +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

A human phenome-interactome network of protein complexes implicated in genetic disorders

36/100 ✓ Peer-reviewed Risk factors Nature biotechnology

Key finding: This was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown complexes likely to be associated with disease. +1 more finding

• Genetics

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Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection

36/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in clinical nutrition and metabolic care

Key finding: Recent findings The docosahexaenoate-derived mediator neuroprotectin D1 is formed in retinal pigment epithelial cells when confronted with oxidative stress, in the brain during experimental stroke, and in the human brain from Alzheimer's disease patients as well as in human brain cells in culture. +4 more findings

• Brain Biology

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Glaucoma as a neurodegenerative disease

36/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in ophthalmology

Key finding: Glaucoma is a leading cause of irreversible world vision loss characterized by progressive retinal ganglion cell death.

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Measures of adiposity and dementia risk in elderly persons

45/100 ✓ Peer-reviewed Vascular contributions Archives of neurology

Key finding: The prospective association between adiposity and dementia differs depending on the anthropometric measure used, and is modified by age. +1 more finding

• Risk Factors

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Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men

43/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Smaller hippocampal volume is associated with psychiatric disorders. +2 more findings

• Brain Scans

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Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus

59/100 ✓ Peer-reviewed Hippocampus size on brain scans Pediatrics

Key finding: Additional studies seem to be warranted. +4 more findings

• Brain Scans

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Brain volumes in relatives of patients with schizophrenia: a meta-analysis

67/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

Key finding: Brain abnormalities are present in nonpsychotic first-degree relatives of patients with schizophrenia and are most pronounced in the hippocampus. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The "amyloid cascade" hypothesis suggests that amyloid-beta (Abeta), the peptide deposited as amyloid plaques, is the primary insult in AD. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Evidence that aging and amyloid promote microglial cell senescence

42/100 ✓ Peer-reviewed Inflammation and the immune system Rejuvenation research

Key finding: However, the specific role of activated microglia in AD pathogenesis remains unresolved. +3 more findings

• Brain Biology

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