Newest studies

Delirium in nursing homes and long-term care facilities: findings of a scoping review of detection tools

44/100 ✓ Peer-reviewed Clinical safety European Geriatric Medicine

Key finding: A total of 58 studies met the inclusion criteria, with most conducted in the USA (37.9%) and Europe. +4 more findings

• Care Services

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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis

48/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroinflammation

Key finding: Hippocampal and serum irisin levels were progressively reduced in CCH mice. +4 more findings

• Brain Biology

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Cataract Aggravates Alzheimer-Like Pathologies and Cognitive Deficits in an APP/PS1 Mouse Model

35/100 ✓ Peer-reviewed Risk genes beyond APOE Neuroscience Bulletin

Key finding: Visual signals were markedly obstructed following surgery to induce cataracts, and these mice presented an increased cerebral amyloid-beta (Aβ) load, while no significant alterations in the levels of enzymes associated with Aβ metabolism were detected. +1 more finding

• Brain Biology
• Genetics
• Digital Tools

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Large-scale single-molecule analysis of tau proteoforms

43/100 ✓ Peer-reviewed Drug development Nature methods

Key finding: We demonstrated that the method can be used on relevant biological samples by examining various neuronal models (iNeuron cells, organoids, MiBrains, and mouse brains) and human samples. +2 more findings

• Brain Biology

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Cerebral small vessel disease and effects of intensive versus standard blood pressure treatment on cardiovascular outcomes and adverse events

47/100 ✓ Peer-reviewed Vascular contributions Journal of Hypertension

Key finding: The mean age of the participants was 68 ± 9 years and 39% were female. +4 more findings

• Risk Factors
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Effectiveness of the Comprehensive Dementia Prevention App 'MELI'

34/100 ✓ Peer-reviewed Prevention trials Asia-pacific Journal of Convergent Research Interchange

Key finding: This study aimed to evaluate the effectiveness of the comprehensive dementia prevention application 'MELI' in enhancing cognitive function and alleviating depressive symptoms among older adults.A total of 50 participants aged 60 and older, enrolled in a dementia prevention program operated in Namdon

• Prevention
• Digital Tools

Full summary, score breakdown and related studies → Original source

LCN2 of cerebrospinal fluid: A potential biomarker for diagnosis and disease progression in Alzheimer's disease

34/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: LCN2 is not only a potential biomarker for the early diagnosis of AD but may also play a significant role in the neurodegenerative processes associated with the disease. +4 more findings

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Age-sex differences in Alzheimer’s and related dementias burden and risk factors in east and Southeast Asia: results from the 2021 GBD study

36/100 ✓ Peer-reviewed Risk factors Frontiers in Aging Neuroscience

Key finding: The findings indicate that the burden of dementia is rising in East and Southeast Asia, with women showing a higher burden across all indicators. +4 more findings

• Risk Factors

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An FDG-PET–Based Machine Learning Framework to Support Neurologic Decision-Making in Alzheimer Disease and Related Disorders

58/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: The discovery cohort contained 3,671 individuals with a mean age of 68 years and consisted of 49% reported female. +4 more findings

• Brain Scans
• Digital Tools

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Alzheimer Hastalığının Tespiti CNN Model Sınıflandırması

29/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Pure and Applied Sciences

Key finding: Merkezi sinir sistemi ve bilişsel fonksiyonların değerlendirilmesindeki gelişmeler, özellikle Alzheimer Hastalığı gibi nörodejeneratif hastalıkların erken teşhisinde önemli avantajlar sağlamaktadır. Çalışmada kullanılan veriler Kaggle platformunda açık kaynaklı olarak bulunan “Augmented Alzheimer MRI Dataset” isimli veri setinden alınmıştır. +4 more findings

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Time Course and Severity of Cognitive Changes as a Function of Aβ Positivity and APOE Genotype in Alzheimer Disease

46/100 ✓ Peer-reviewed Genetics Neurology

Key finding: We analyzed data from 1,542 participants (mean age = 72.2 years, SD = 7.2; 50.8% female; mean education = 16.3 years, SD = 2.6) and found that APOE4 was associated with steeper declines in episodic memory as a function of Aβ duration. +4 more findings

• Genetics
• Brain Biology

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Statin Initiation and Dementia Incidence in a Large Health Care System From 1997 to 2020: A Target Trial Emulation Study

66/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Among eligible participants (n = 705,061), 264,294 individuals (37.5% of eligible participants) initiated any statin during 2001-2010 ("initiators"), of whom 249,613 (94.4%) were matched with 255,937 unique noninitiators to create the analytic sample (322,358 unique participants; mean age at baseline = 67.4 years; 55.1% female). +2 more findings

• Risk Factors
• Clinical Trials

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Evaluating Genomic and Clinical Risk Factors for Alzheimer's Disease in Individuals with Hypertension

63/100 ✓ Peer-reviewed Risk factors Biomedicines

Key finding: Obesity and Area Deprivation Index, a measure of socioeconomic status, were significantly associated with elevated AD risk within the hypertensive cohort. +3 more findings

• Risk Factors
• Genetics

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Providing Culturally Centered Palliative Care to Latino Older Adults with Dementia and Their Families

40/100 ✓ Peer-reviewed End-of-life care AJN American Journal of Nursing

Key finding: Palliative care is essential for patients with serious illness, including those with dementia. +4 more findings

• End-of-Life Care
• Caregiving
• Health Equity

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Endoscopic characterization of oropharyngeal dysphagia in patients with dementia

37/100 ✓ Peer-reviewed Clinical safety Frontiers in Aging

Key finding: A comparative analysis of dysphagia pathologies across the three dementia types revealed a relatively mixed picture of various dysphagia findings in all dementia types. +4 more findings

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Serum level changes of the synaptic marker beta-synuclein in Alzheimer’s disease continuum and other dementias

46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Neurology Neurosurgery & Psychiatry

Key finding: Serum beta-synuclein level was progressively increased in the AD continuum across the preclinical, MCI and dementia stages compared with controls and was correlated with serum pTau181 (r=0.710), NfL (r=0.494) and GFAP concentrations (r=0.621, p<0.001 for all). +4 more findings

• Diagnosis
• Biomarkers
• Brain Biology

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Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia

37/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Molecular Neuroscience

Key finding: Imbalances in iron metabolism render nerve cells highly susceptible to cell death induced by iron accumulation. +4 more findings

• Other Dementias
• Brain Biology

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Performance evaluation of Alzheimer’s disease detection in brain MRI images using the Alzheimer-net classifier

28/100 ✓ Peer-reviewed Brain scans and imaging Engineering Research Express

Key finding: The proposed approach achieves 97.9% AD Classification Index (ADCI) for the Kaggle dataset and 97.9% ADCI for the MIRIAD dataset. +2 more findings

• Brain Scans

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The Impact of Immunotherapy Drugs on the Human Nervous System

28/100 ✓ Peer-reviewed Treatments MedScien

Key finding: There is increasing evidence that immunotherapies are associated with neurotoxic side effects such as neuroinflammation, encephalitis, cognitive decline and peripheral neuropathy which can greatly affect patient’s quality of life.

• Treatments
• Side Effects

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Cerebrospinal Fluid Biomarkers of Alzheimer Disease

30/100 ✓ Peer-reviewed Treatments Annals of Clinical and Experimental Neurology

Key finding: Current international guidelines for the clinical diagnosis of AD consider the diagnosis to be both clinical and biological. +4 more findings

• Biomarkers
• Treatments

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The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors

51/100 ✓ Peer-reviewed Costs and economics Alzheimer's research & therapy

Key finding: Healthcare costs are already elevated in early subjective and objective cognitive impairment, driven by formal and informal care. +4 more findings

• Policy
• Early Stage
• Risk Factors

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The burden of stroke, ischaemic heart disease, and dementia in Africa, 1990–2021: an ecological analysis of the Global Burden of Disease 2021

40/100 ✓ Peer-reviewed Vascular contributions The Lancet Global Health

Key finding: In Africa in 2021, 17·3 (95% UI 15·5-19·2) million DALYs were lost due to strokes, 17·6 (15·5-19·6) million were lost due to ischaemic heart diseases, and 1·8 (0·8-4·0) million were lost due to dementia. +4 more findings

• Risk Factors

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Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections

64/100 ✓ Peer-reviewed How common it is npj Vaccines

Key finding: AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. +2 more findings

• Risk Factors
• Prevention

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Cross-Sectional and Longitudinal Associations of Neighborhood Disadvantage With Fluid Biomarkers of Neuroinflammation and Neurodegeneration

65/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Greater neighborhood disadvantage was associated with elevated inflammatory and AD CSF biomarkers cross-sectionally and longitudinal increases in a nonspecific inflammatory blood biomarker. +4 more findings

• Biomarkers
• Health Equity
• Brain Biology

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System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment

37/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia (New York, N. Y.)

Key finding: The AD care pathway must be transformed to meet the challenge of bringing these new therapies to the increasing number of people living with AD within the existing healthcare framework. +4 more findings

• Care Services
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source