Newest studies

Bridging the gap: Short structural variants in the genetics of anorexia nervosa

41/100 ✓ Peer-reviewed Genetics The International journal of eating disorders

Key finding: Twin and family studies estimate heritability (h2 ) to be 57%-64%, and genome-wide association studies (GWAS) reveal significant genetic correlations with psychiatric and anthropometric traits and a total of nine genome-wide significant loci. +2 more findings

• Genetics

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The cerebrospinal fluid biomarker ratio Aβ42/40 identifies amyloid positron emission tomography positivity better than Aβ42 alone in a heterogeneous memory clinic cohort

53/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: CSF Aβ42/40 ratio can predict PET amyloid positivity with high accuracy in patients with a range of cognitive disorders when evaluating Aβ pathology independent of tau and neurodegeneration for research purposes. +3 more findings

• Biomarkers
• Brain Scans
• Care Services

Full summary, score breakdown and related studies → Original source

A qualitative study with people with young-onset dementia and their family caregivers on advance care planning: A holistic, flexible, and relational approach is recommended

43/100 ✓ Peer-reviewed End-of-life care Palliative medicine

Key finding: Engagement in advance care planning might be hindered if it is too medicalized and exclusively patient-centered.

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Increased Precision in County-Level Volume Estimates in the United States National Forest Inventory With Area-Level Small Area Estimation

32/100 ✓ Peer-reviewed Risk factors Frontiers in Forests and Global Change

Key finding: Accounting for spatial autocorrelation among adjacent counties provided further gains in precision when the three states were treated as a single forest land population; however, analyses conducted one state at a time showed that good results could be achieved without accounting for spatial autocorrelation. +2 more findings

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Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

53/100 ✓ Peer-reviewed Caregiving Alzheimer's research & therapy

Key finding: These findings suggest that the loss of perivascular AQP4 localization may contribute to the development of AD pathology in human populations. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Biomarker modeling of Alzheimer's disease using PET-based Braak staging

55/100 ✓ Peer-reviewed Brain scans and imaging Nature aging

Key finding: We identified nonlinear AD biomarker trajectories corresponding to the spatial extent of tau-PET, with modest biomarker changes detectable by Braak stage II and significant changes occurring at stages III-IV, followed by plateaus. +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood biomarkers for Alzheimer's disease and related disorders

40/100 ✓ Peer-reviewed Biomarkers Acta neurologica Scandinavica

Key finding: AD is associated with β-amyloid and tau pathologies, which can be quantified using cerebrospinal fluid and imaging biomarkers and, more recently, using highly sensitive blood tests.

• Biomarkers

Full summary, score breakdown and related studies → Original source

The management of dementia worldwide: A review on policy practices, clinical guidelines, end-of-life care, and challenge along with aging population

40/100 ✓ Peer-reviewed End-of-life care Bioscience trends

Key finding: Detection of dementia requires knowledge of medical history and cognitive examination, while dementia diagnosis requires more professional medical examination results. +1 more finding

• End-of-Life Care
• Policy

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Time spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants

64/100 ✓ Peer-reviewed Long-term cohort studies BMC medicine

Key finding: Sunlight exposure had a J-shaped association with dementia risk. +1 more finding

• Risk Factors

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[Diagnosing Alzheimer's dementia - a playground for academics or a sensible clinical measure?]

31/100 ✓ Peer-reviewed Drug development Deutsche medizinische Wochenschrift (1946)

Key finding: The diagnostic workup of Alzheimer's dementia is complex, and its clinical relevance debatable considering the current lack of disease-modifying treatments. +3 more findings

• Treatments
• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuron

Key finding: People with Down syndrome (DS) have increased risk of Alzheimer disease (AD), presumably conferred through genetic predispositions arising from trisomy 21. +1 more finding

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Nursing Home Residents' Positive Behavioral Responses to Individualized Music Predict Improvements in Sundowning Symptoms After Music Listening

50/100 ✓ Peer-reviewed Health systems and care delivery Journal of aging and health

Key finding: As hypothesized, residents who exhibited a greater number of positive reactive behaviors while listening to music also evidenced more improvements in their confusion, disengagement, unresponsiveness, and restlessness after their music-listening session. +2 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Polygenic risk score as a possible tool for identifying familial monogenic causes of complex diseases

41/100 ✓ Peer-reviewed Genetics Genetics in medicine : official journal of the American College of Medical Genetics

Key finding: Monogenic causes of complex diseases were more prevalent among individuals with a parental disease history than in the rest of the population. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Neurodegenerative Disorders and Sleep

41/100 ✓ Peer-reviewed Risk factors Sleep medicine clinics

Key finding: These symptoms are likely multifactorial, caused by their underlying neurologic disorder and also by medications and other comorbidities associated with the progressive condition. +1 more finding

• Lifestyle

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Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?

35/100 ✓ Peer-reviewed Drug development Clinical nuclear medicine

Key finding: We believe that the amyloid-PET scans, perceived as showing decreasing amyloid deposits, are an expression of increased cerebral cell death due to aducanumab treatment, so that with time one should instead expect a worsening and not an improvement in the treated patients' condition.

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

A possible blood plasma biomarker for early-stage Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers PloS one

Key finding: We found that plasma concentrations of a phospholipid metabolite, 2-aminoethyl dihydrogen phosphate, normalized by taurine concentrations, distinguish blood samples of patients with early-stage AD.

• Biomarkers
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study

58/100 ✓ Peer-reviewed Long-term cohort studies Journal of cachexia, sarcopenia and muscle

Key finding: This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. +3 more findings

• Risk Factors

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Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life

68/100 ✓ Peer-reviewed Digital health tools Ageing research reviews

Key finding: On meta-analysis, PARO had no ST or LT compared to UC or AC over 5-12 weeks on agitation (ST vs UC, 4 trials, 153 participants: pooled standardized mean difference (SMD) 0.25; - 0.57 to 0.06; LT vs UC; 2 trials, 77 participants, SMD = -0.24; - 0.94, 0.46), cognition (ST vs UC, 3 trials, 128 particip

• Digital Tools

Full summary, score breakdown and related studies → Original source

Advances in the development of new biomarkers for Alzheimer's disease

50/100 ✓ Peer-reviewed Caregiving Translational neurodegeneration

Key finding: There is a considerable potential in using microRNA (miRNA) as markers of AD, and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual patients. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Epidemiology and economic burden of Lewy body dementia in the United States

45/100 ✓ Peer-reviewed Costs and economics Current medical research and opinion

Key finding: From 2010 to 2016, the incidence and prevalence rates of LBD among Medicare beneficiaries ranged from 0.21%-0.18% and 0.90%-0.83%, respectively. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Advanced MRI in cerebral small vessel disease

41/100 ✓ Peer-reviewed Vascular contributions International journal of stroke : official journal of the International Stroke Society

Key finding: Such techniques include the use of dynamic contrast enhanced MRI to measure blood-brain barrier permeability, and MRI methods to assess cerebrovascular reactivity. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease

41/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: "Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Somatic genomic changes in single Alzheimer's disease neurons

45/100 ✓ Peer-reviewed Genetics Nature

Key finding: During normal ageing, neurons progressively accumulate somatic mutations 5 at rates similar to those of dividing cells 6,7 which suggests that genetic factors, environmental exposures or disease states might influence this accumulation 5 . +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of Cardiovascular Risk Trajectory With Cognitive Decline and Incident Dementia

69/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The findings of the current study show that the longitudinal, cumulative trajectory of cardiovascular risk is predictive of dementia risk and associated with the emergence of memory decline. +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Progressive cognitive impairment and familial spastic paraparesis due to PRESENILIN 1 mutation: anatomoclinical characterization

41/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neurology

Key finding: The three female patients had an age of onset of symptoms of 38-51 years. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source