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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,126–9,150 of 27,380 studies, newest first · page 366 of 1096.

March 2022 16

  1. 2022-03-01

    Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records

    ✓ Peer-reviewed Risk factors The Lancet. Digital health

    Key finding: In both the British and French studies, ten health conditions were significantly positively associated with increased Alzheimer's disease risk, in a window of exposure from 2-10 years before Alzheimer's disease diagnosis, comprising major depressive disorder (UK OR 1·34, 95% CI 1·23-1·46; France OR 1·73, 1·57-1·91), anxiety (UK OR 1·36, 1·25-1·47; France OR 1·50, 1·36-1·65), reaction to severe stress and adjustment disorders (UK OR 1·40, 1·24-1·59; France OR 1·83, 1·55-2·15), hearing loss (UK OR 1·19, 1·11-1·28; France OR 1·51, 1·21-1·89), constipation (UK OR 1·31, 1·22-1·41; France OR 1·59, 1·44-1·75), spondylosis (UK OR 1·26, 1·14-1·39; France OR 1·62, 1·44-1·81), abnormal weight loss (UK OR 1·47, 1·33-1·63; France OR 1·88, 1·56-2·26), malaise and fatigue (UK OR 1·23, 1·14-1·32; France OR 1·59, 1·46-1·73), memory loss (UK OR 7·63, 6·65-8·76; France OR 4·41, 3·07-6·34), and syncope and collapse (UK OR 1·23, 1·10-1·37; France OR 1·57, 1·26-1·96). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-03-01

    Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study

    ✓ Peer-reviewed Genetics The Lancet. Neurology

    Key finding: We retrospectively assessed the diagnostic accuracy of whole genome sequencing to detect the most common repeat expansion loci associated with neurological outcomes (AR, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, C9orf72, CACNA1A, DMPK, FMR1, FXN, HTT, and TBP) using samples obtained within the National Health Service in England from patients who were suspected of having neurological disorders; previous PCR test results were used as the reference standard. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-03-01

    Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies

    ✓ Peer-reviewed Biomarkers Cardiovascular research

    Key finding: High plasma HDL cholesterol was observationally associated with increased risk of any dementia and Alzheimer's disease, suggesting that HDL cholesterol can be used as an easily accessible plasma biomarker for individual risk assessment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-03-01

    Atrial fibrillation in the UK: predicting costs of an emerging epidemic recognizing and forecasting the cost drivers of atrial fibrillation-related costs

    ✓ Peer-reviewed Vascular contributions European heart journal. Quality of care & clinical outcomes

    Key finding: Atrial fibrillation already accounts for a significant amount of National Health Service (NHS) funding, and over the coming years is highly likely to impose a growing cost on NHS budgets and the wider UK healthcare system. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-03-01

    MIND Diet and Cognitive Function in Puerto Rican Older Adults

    ✓ Peer-reviewed Prevention trials The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Adherence to the MIND diet was associated with better cognitive function at baseline and over 8 years of follow-up; however, MIND diet was not associated with 8-year cognitive trajectory. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-03-01

    18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment

    ✓ Peer-reviewed Inflammation and the immune system Yonsei medical journal

    Key finding: The results of the present study suggest that increased 18 F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ- aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498). +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-03-01

    Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study

    ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

    Key finding: Brain regions with higher synaptic density are associated with a higher 18F-AV-1451 binding in progressive supranuclear palsy/corticobasal degeneration, but this association diminishes with disease severity.

    Full summary, score breakdown and related studies → Original source

  8. 2022-03-01

    Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization

    ✓ Peer-reviewed Long-term cohort studies The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Delirium is a distressing neurocognitive disorder recently linked to sleep disturbances. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-03-01

    Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases

    ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

    Key finding: Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-03-01

    Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia

    ✓ Peer-reviewed Disparities JAMA

    Key finding: In this exploratory analysis of a US community-based cohort, several echocardiographic measures of lower LA function were significantly associated with an increased risk of subsequent dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2022-03-01

    Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study

    ✓ Peer-reviewed Disparities JAMA neurology

    Key finding: In this study, risk of dementia significantly increased after ischemic stroke, independent of vascular risk factors. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-03-01

    Simulated Electroconvulsive Therapy: A Novel Approach to a Control Group in Clinical Trials

    ✓ Peer-reviewed Treatments The journal of ECT

    Key finding: Validation of the safety and efficacy of ECT in patients with advanced AD with refractory agitation and aggression is necessary. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-03-01

    Amyloid-Related Imaging Abnormalities and β-Amyloid-Targeting Antibodies: A Systematic Review

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: Apolipoprotein E (ApoE) ε4 genotype was the main risk factor for both ARIA types; ARIA-E incidence was further associated with treatment dose, affecting the 55% of ApoE ε4 carriers in the high-dose aducanumab treatment group. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2022-03-01

    Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Participants with higher total-tau and NfL at baseline had a higher risk of stroke and several stroke subtypes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-03-01

    Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: In DIAD, clinical disease stage and BDNF Met66 were associated with cognitive impairment and levels of site-specific tau phosphorylation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-03-01

    Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

February 2022 9

  1. 2022-02-28

    CSF biomarkers and plasma p‐tau181 as predictors of longitudinal tau accumulation: Implications for clinical trial design

    ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

    Key finding: P‐tau181 in CSF and plasma predicted tau accumulation (r > 0.36, P < .001), even in AD‐continuum individuals with normal baseline tau‐PET (A+T–; r > 0.37, P < .05). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-02-28

    Tau-PET imaging predicts cognitive decline and brain atrophy progression in early Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Journal of neurology, neurosurgery, and psychiatry

    Key finding: Baseline tau-PET was strongly associated with the subsequent cognitive decline in regions that are usually associated with each cognitive domain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-02-28

    Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI

    ✓ Peer-reviewed Biomarkers Aging clinical and experimental research

    Key finding: Our findings demonstrated a significant association between plasma NFL levels and disrupted WM microstructure across the brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-02-28

    Hearing Loss and Cognition: What We Know and Where We Need to Go

    ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

    Key finding: Although a causal association remains to be determined, epidemiologic evidence suggests an association between hearing loss and increased risk of dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2022-02-28

    Disease Modeling and Model-Based Meta-Analyses to Define a New Direction for a Phase III Program of Gantenerumab in Alzheimer's Disease

    ✓ Peer-reviewed Treatments Clinical pharmacology and therapeutics

    Key finding: Selecting the right dose is a significant challenge in designing clinical development programs, especially for slowly progressing diseases lacking predictive biomarkers of efficacy that may require long-term treatment to assess clinical benefit. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2022-02-28

    Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation

    ✓ Peer-reviewed Genetics International journal of biological sciences

    Key finding: FA treatment significantly improved mitochondrial function and inhibited lipid peroxidation in Aβ 1-42 -exposed N2a cells. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-02-28

    Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer's disease and vascular pathology

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: GFAP was associated with amyloid and tau PET in multivariable models. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2022-02-26

    Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia

    ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

    Key finding: Frontotemporal dementia associated with granulin (GRN) mutations presents asymmetric brain atrophy. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-02-26

    Increased retention of tau PET ligand [18F]-AV1451 in Alzheimer's Disease Psychosis

    ✓ Peer-reviewed Brain scans and imaging Translational psychiatry

    Key finding: In order to determine whether the development of psychosis and worsened prognosis in AD is associated with an increased burden of tau pathology that can be identified with tau imaging, we identified subjects within the Alzheimer's disease neuroimaging initiative (ADNI) who had [18F]-AV1451 imaging at baseline and became psychotic over the course of the study (N = 17) and matched them 1:3 for gender, age, and education to subjects who had [18F]-AV1451 imaging at baseline and did not become psychotic (N = 50). +1 more finding

    Full summary, score breakdown and related studies → Original source

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