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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,376–10,400 of 27,380 studies, newest first · page 416 of 1096.

March 2021 25

  1. 2021-03-27

    Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment

    ✓ Peer-reviewed Laboratory science Alzheimer's Research & Therapy

    Key finding: In 160 MCI patients, baseline plasma GFAP predicted abnormal amyloid status with AUC 0.79, improving to 0.86 when combined with APOE genotype +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-03-26

    Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

    ✓ Peer-reviewed Disease mechanisms Cells

    Key finding: Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-03-26

    Efficacy and safety of GV1001 in patients with moderate-to-severe Alzheimer's disease already receiving donepezil: a phase 2 randomized, double-blind, placebo-controlled, multicenter clinical trial

    ✓ Peer-reviewed Clinical trials Alzheimer's research & therapy

    Key finding: Group 3 showed less decrease in the SIB score at 12 and 24 weeks compared with group 1 (P < 0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-03-26

    Diagnostic and prognostic blood biomarkers in vascular dementia: From the viewpoint of ischemic stroke

    ✓ Peer-reviewed Biomarkers Neurochemistry international

    Key finding: VaD and AIS have similar pathological conditions that are associated with small vessel disease (SVD) such as oxidative stress, inflammation, endothelial dysfunction, and neuronal injury.

    Full summary, score breakdown and related studies → Original source

  5. 2021-03-26

    Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

    ✓ Peer-reviewed Prevention trials Physiological reviews

    Key finding: This review focuses primarily on autoregulation and its clinical implications. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-03-26

    Mitigating the negative impacts of aging on cognitive function; modifiable factors associated with increasing cognitive reserve

    ✓ Peer-reviewed Prevention trials The European journal of neuroscience

    Key finding: Research suggests that social, physical, and cognitively challenging activities during lifetime, could mitigate the negative effects of aging on cognitive function.

    Full summary, score breakdown and related studies → Original source

  7. 2021-03-25

    Antipsychotic Initiation Among Older Dementia Patients Using Cholinesterase Inhibitors: A National Retrospective Cohort Study

    ✓ Peer-reviewed Treatments Drugs & aging

    Key finding: The study cohort consisted of 178,441 older adults with dementia who were new users of ChEIs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-03-25

    Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology

    Key finding: Here, we found that TREM2 interacted with CSF1R based on a co-immunoprecipitation assay. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-03-25

    scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from multiple grand challenges, including the sequencing sparsity and complex differential patterns in gene expression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-03-25

    Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: Plasma NfL indicates neurodegeneration while plasma p-tau181 levels can serve as a biomarker of cerebral AD pathology and cognitive decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2021-03-25

    Is neuroticism differentially associated with risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia?

    ✓ Peer-reviewed Long-term cohort studies Journal of psychiatric research

    Key finding: Participants from the UK Biobank (N = 401,422) completed a self-report neuroticism scale in 2006-2010 and incident all-cause dementia, AD, VD, and FTD were ascertained using electronic health records or death records up to 2018. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-03-25

    Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

    ✓ Peer-reviewed Genetics Frontiers in aging neuroscience

    Key finding: This cerebrovascular disease results in neurodegeneration via acute, chronic, local, and systemic mechanisms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2021-03-24

    Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

    Key finding: The innate immune system is a viable target for therapeutic intervention in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-03-24

    Hospital-based acute care in the last 30 days of life among patients with chronic disease that received early, late or no specialist palliative care: a retrospective cohort study of eight chronic disease groups

    ✓ Peer-reviewed End-of-life care BMJ open

    Key finding: Early specialist PC exposure reduced the risk of hospital-based acute care in the last 30 days of life for all chronic disease groups except dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-03-24

    Α Virtual Reality App for Physical and Cognitive Training of Older People With Mild Cognitive Impairment: Mixed Methods Feasibility Study

    ✓ Peer-reviewed Prevention trials JMIR serious games

    Key finding: However, to replace existing nonpharmaceutical treatment training protocols, VR platforms need significant improvement if they are to appeal to older people with symptoms of cognitive decline and meet their specific needs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-03-24

    Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The relationship between persistent loneliness and Alzheimer's disease (AD) is unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-03-23

    Bilingualism: Pathway to Cognitive Reserve

    ✓ Peer-reviewed Risk factors Trends in cognitive sciences

    Key finding: In all cases, bilinguals revealed patterns that were consistent with the interpretation of protection from cognitive reserve when compared with monolinguals.

    Full summary, score breakdown and related studies → Original source

  18. 2021-03-23

    Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology

    ✓ Peer-reviewed Genetics Acta neuropathologica communications

    Key finding: Here, we leveraged multimodal longitudinal data from a large, population-based sample of older adults to discover genetic factors associated with differential cognitive resilience to brain amyloidosis determined by positron emission tomography (PET). +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-03-23

    VAMP-2 Is a Surrogate Cerebrospinal Fluid Marker of Alzheimer-related Cognitive Impairment in Adults With Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's research & therapy

    Key finding: Previously, GluA4 and Neuronal Pentraxin 2 (NPTX2) showed limited potential as cerebrospinal fluid (CSF) markers of cognitive impairment in adults with DS. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-03-23

    The Prevalence of Mild Cognitive Impairment among Chinese People: A Meta-Analysis

    ✓ Peer-reviewed Disparities Neuroepidemiology

    Key finding: The prevalence of MCI in China was 15.4%, which varied by demographics, lifestyles, morbidity, screening tools, and diagnostic criteria. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2021-03-23

    2021 Alzheimer's disease facts and figures

    ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-03-22

    Racial disparity in end-of-life hospitalizations among nursing home residents with dementia

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: We found disparities between black and white residents with ADRD both within and across facilities. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-03-22

    Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: These findings underscore the importance of blood pressure control in midlife to mitigate dementia risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-03-20

    The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease

    ✓ Peer-reviewed Genetics Genes

    Key finding: Among the most significant GWAS hits are three complement genes: CLU, encoding the fluid-phase complement inhibitor clusterin; CR1 encoding complement receptor 1 (CR1); and recently, C1S encoding the complement enzyme C1s. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-03-20

    Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease

    ✓ Peer-reviewed Drug development 3 Biotech

    Key finding: The above suggest that anti-diabetic drugs may be promising strategies for AD disease-modifying treatments.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →