alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,751–9,775 of 27,380 studies, newest first · page 391 of 1096.

October 2021 3

  1. 2021-10-01

    Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults

    ✓ Peer-reviewed Brain scans and imaging JAMA network open

    Key finding: In 303 participants (mean [SD] age, 73.16 [5.19] years, 181 [60%] women, 96 [32%] non-Hispanic White, 113 [37%] Non-Hispanic Black, 94 [31%] Hispanic), baseline WMH volumes were associated with cortical thinning in medial temporal and frontal/parietal regions. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-10-01

    Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease

    ✓ Peer-reviewed Genetics Brain : a journal of neurology

    Key finding: We found that longitudinal changes in cognitive function measured by the cognitive composite decreased at low and high values of total sleep time (P < 0.001), time in non-REM (P < 0.001) and REM sleep (P < 0.001), sleep efficiency (P < 0.01) and <1 Hz and 1-4.5 Hz non-REM slow wave activity (P < 0.001) even after adjusting for age, CSF total tau/amyloid-β42 ratio, APOE ε4 carrier status, years of education and sex. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-10-01

    Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: The 4417 participants in the study included 2618 women (59%) and had a mean (SD) age of 71.3 (4.7) years. +4 more findings

    Full summary, score breakdown and related studies → Original source

September 2021 22

  1. 2021-09-30

    Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

    ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

    Key finding: In the present study, we found that 10 or 50 μM donepezil significantly decreased the LPS-induced increases in the mRNA levels of a number of proinflammatory cytokines in BV2 microglial cells, whereas 50 μM rivastigmine significantly diminished only LPS-stimulated IL-6 mRNA levels. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-09-30

    Exercise interventions in Alzheimer's disease: A systematic review and meta-analysis of randomized controlled trials

    ✓ Peer-reviewed Prevention trials Ageing research reviews

    Key finding: 28 studies (total n = 1337 participants, average age 79-90 years) were included in the systematic review, of which 21 could be meta-analyzed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-09-30

    GenoRisk: A polygenic risk score for Alzheimer's disease

    ✓ Peer-reviewed Genetics Alzheimer's & dementia (New York, N. Y.)

    Key finding: The elastic net model that included age, age x sex interaction, allelic APOE terms, and 29 additional SNPs performed the best. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-09-30

    Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: BRANCH reliably captures meaningful cognitive information remotely, suggesting promise as a digital cognitive marker sensitive early in the AD trajectory. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2021-09-30

    METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events

    ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration

    Key finding: These data suggested that METTL3 reduction-mediated m 6 A dysregulation likely contributes to neurodegeneration in AD which may be a therapeutic target for AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-09-30

    Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease

    ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

    Key finding: Strikingly gene-expression, network-based analysis and cell type deconvolution approaches revealed a consistent immune signature in the brain and blood of female AD patients that was absent in males. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-09-29

    Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia

    ✓ Peer-reviewed Long-term cohort studies Diabetes care

    Key finding: Type 2 diabetes is associated with increased risks of cognitive dysfunction and brain abnormalities. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-09-29

    Structure-based classification of tauopathies

    ✓ Peer-reviewed Getting a diagnosis Nature

    Key finding: Tau protofilament structures from inherited cases of mutations at positions +3 or +16 in intron 10 of MAPT (the microtubule-associated protein tau gene) are also identical to those from AGD, suggesting that relative overproduction of four-repeat tau can give rise to the AGD fold. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2021-09-28

    Reduced TREM2 activation in microglia of patients with Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics FEBS open bio

    Key finding: Differentially expressed genes (DEGs) following TREM2 activation were compared with the gene set extracted from microglial single nuclear RNA sequencing data of patients with AD, using gene set enrichment analysis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-09-28

    Palliative care interventions in advanced dementia

    ✓ Peer-reviewed End-of-life care The Cochrane database of systematic reviews

    Key finding: We assessed the risk of bias of included studies using the Cochrane Risk of Bias tool and the overall certainty of the evidence for each outcome using GRADE. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-09-28

    Machine learning methods for predicting progression from mild cognitive impairment to Alzheimer's disease dementia: a systematic review

    ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

    Key finding: Although the performance of the different methods still has room for improvement, the results are promising and this methodology has a great potential as a support tool for clinicians and healthcare professionals. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-09-27

    Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer’s Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota

    ✓ Peer-reviewed Disease mechanisms ACS Applied Materials & Interfaces

    Key finding: Alzheimer’s disease (AD) is a neurodegenerative disease associated with amyloid-β (Aβ) deposition, leading to neurotoxicity (oxidative stress and neuroinflammation) and gut microbiota imbalance.

    Full summary, score breakdown and related studies → Original source

  13. 2021-09-27

    Expected wait times for access to a disease-modifying Alzheimer's treatment in the United States

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Better diagnostic tools at initial evaluation may reduce unnecessary delays in access to treatment.

    Full summary, score breakdown and related studies → Original source

  14. 2021-09-27

    Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Multiple variables affect plasma biomarkers of amyloid pathology and neurodegeneration among CU in the general population. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-09-27

    Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies

    ✓ Peer-reviewed Biomarkers Frontiers in neuroscience

    Key finding: Any of the five Nf subunits - neurofilament light chain (NfL), neurofilament medium chain (NfM), neurofilament heavy chain (NfH), alpha-internexin (INA) and peripherin (PRPH) may be altered in a given neuropathological condition. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-09-27

    Dementia in Africa: Current evidence, knowledge gaps, and future directions

    ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The apolipoprotein E (APOE) ε4 allele is most studied but has shown differential effects within African ancestry compared to Caucasian.

    Full summary, score breakdown and related studies → Original source

  17. 2021-09-27

    Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study

    ✓ Peer-reviewed Long-term cohort studies The Lancet regional health. Europe

    Key finding: Understanding the mental health consequences of child maltreatment at different life stages is important in accurately quantifying the burden of maltreatment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-09-26

    Cognitive Reserve Characteristics and Occupational Performance Implications in People with Mild Cognitive Impairment

    ✓ Peer-reviewed Risk factors Healthcare (Basel, Switzerland)

    Key finding: The Cognitive Reserve hypothesis suggests that there are individual differences in the ability to cope with the pathologic changes in Alzheimer's Disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-09-24

    Towards a Consensus on Alzheimer's Disease Comorbidity?

    ✓ Peer-reviewed Risk factors Journal of clinical medicine

    Key finding: First, we review shortly the diseases most associated with AD in the clinic. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-09-24

    An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models

    ✓ Peer-reviewed Risk factors Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    Key finding: Third, it is demonstrated that the infiltrating microglia obtain M1 phenotype induced by interleukin-1β and interferon-γ from neurons and reactive astrocytes under the PM2.5 exposure. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2021-09-24

    Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature

    ✓ Peer-reviewed Risk factors Environmental health perspectives

    Key finding: Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between PM2.5 and cognitive decline.

    Full summary, score breakdown and related studies → Original source

  22. 2021-09-24

    Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

    ✓ Peer-reviewed Genetics Frontiers in neuroscience

    Key finding: In this review, the results so far obtained regarding the role of microglia in neurodegenerative disorders will be discussed. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →