Newest studies

Association of the top 20 Alzheimer's disease risk genes with [18F]flortaucipir PET

45/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: APOE ε4 showed significant (P < .05) associations with tau deposition across all disease stages. +3 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Role of Environmental Toxicants on Neurodegenerative Disorders

43/100 ✓ Peer-reviewed Risk factors Frontiers in toxicology

Key finding: Besides, solvent exposure is also a significant contributor to neurological diseases.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Comparable diagnostic performances and strong correlations between serum versus plasma pairs suggest that p-tau analyses can be expanded to research cohorts and hospital systems that prefer serum to other blood matrices. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Commentary: Aducanumab-Related ARIA: Paean or Lament?

33/100 ✓ Peer-reviewed Drug development Clinical nuclear medicine

Key finding: Høilund-Carlsen and colleagues raise important issues related to amyloid PET, diagnosis of Alzheimer disease, and recently approved antiamyloid treatment aducanumab.

• Treatments

Full summary, score breakdown and related studies → Original source

Interprofessional collaboration in palliative dementia care through the eyes of informal caregivers

41/100 ✓ Peer-reviewed Health systems and care delivery Dementia (London, England)

Key finding: Our study revealed that intrinsic and extrinsic factors and interprofessional collaboration among healthcare professionals affected informal caregivers' collaborative roles. +1 more finding

• Care Services
• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Area Deprivation Index and Gut-Brain Axis in Cirrhosis

42/100 ✓ Peer-reviewed Risk factors Clinical and Translational Gastroenterology

Key finding: A total of 321 people with cirrhosis (60 years, 78% men, 75% non-Hispanic White, 24% non-Hispanic African American, 4% Hispanic) were included. 45% had prior HE and 56% MHE. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants

65/100 ✓ Peer-reviewed Long-term cohort studies Molecular psychiatry

Key finding: Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Increasing the Cognitive Screening Efficiency of Global Phase III Trials in Early Alzheimer Disease: The Cognitive Task Force

32/100 ✓ Peer-reviewed Drug development Alzheimer disease and associated disorders

Key finding: A Cognitive Task Force (CTF) was established for the MissionAD program with the aim of reducing the screen failure (SF) rate to ∼30% and thereby reduce unnecessary subject burden, site burden, and excess trial costs. +3 more findings

• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

Deep learning-based brain age prediction in normal aging and dementia

59/100 ✓ Peer-reviewed Digital health tools Nature aging

Key finding: Occlusion analysis, performed to facilitate the interpretation of the model, revealed that the model learns an age- and modality-specific pattern of brain aging.

• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease

64/100 ✓ Peer-reviewed Risk factors GeroScience

Key finding: Both objective and perceived social isolations were associated with future cognitive decline and increase risk of Alzheimer's disease (AD). +4 more findings

• Lifestyle
• Early Stage

Full summary, score breakdown and related studies → Original source

Adherence to the Mediterranean diet and incident frailty: Results from a longitudinal study

71/100 ✓ Peer-reviewed Prevention and risk Maturitas

Key finding: 176 and 131 participants developed incident frailty, as measured with the FI and TFI respectively. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Evaluation of four gamma-based methods for calculating confidence intervals for age-adjusted mortality rates when data are sparse

36/100 ✓ Peer-reviewed Risk factors Population Health Metrics

Key finding: The three modifications had comparable performance when the number of deaths was large relative to the denominator and the age distribution was as in the standard population. +4 more findings

Full summary, score breakdown and related studies → Original source

Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants

61/100 ✓ Peer-reviewed Long-term cohort studies Biology of sex differences

Key finding: Whether the association of cardiovascular diseases (CVDs) with dementia differs by sex remains unclear, and the role of socioeconomic, lifestyle, genetic, and medical factors in their association is unknown. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

α-synuclein as an emerging pathophysiological biomarker of Alzheimer's disease

41/100 ✓ Peer-reviewed Brain tissue and pathology Expert review of molecular diagnostics

Key finding: α-syn aggregates represent the pathological hallmark of synucleinopathies as well as a frequent copathology (almost 1/3 of cases) in AD. +4 more findings

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Obesity as a Risk Factor for Dementia and Alzheimer's Disease: The Role of Leptin

50/100 ✓ Peer-reviewed Prevention and risk International journal of molecular sciences

Key finding: In this review, we discuss different leptin resistance mechanisms that could be implicated in increasing the risk of developing AD, as leptin resistance is frequently associated with obesity, which is a chronic low-grade inflammatory state, and obesity is considered a risk factor for AD.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Targeting endothelial ion signalling to rescue cerebral blood flow in cerebral disorders

41/100 ✓ Peer-reviewed Vascular contributions Vascular pharmacology

Key finding: The mechanism whereby an increase in neuronal activity (NA) leads to a local elevation in cerebral blood flow to supply the active neurons with oxygen and nutrients and remove the catabolic waste has been termed neurovascular coupling (NVC). +4 more findings

Full summary, score breakdown and related studies → Original source

Individualised computerised cognitive training for community-dwelling people with mild cognitive impairment: study protocol of a completely virtual, randomised, controlled trial

50/100 ✓ Peer-reviewed Cognitive tests and assessment Trials

Key finding: This is the first study to investigate the effect of MAKSCog, an individualised CCT, specifically developed for people with different subtypes of MCI. +4 more findings

• Clinical Trials
• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI

64/100 ✓ Peer-reviewed Tau biomarkers Brain sciences

Key finding: Biomarkers were extracted from a total of 42 participants with longitudinal time points representing 164 imaging volumes. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Alzheimer's disease drug development pipeline: 2022

57/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)

Key finding: The AD drug development pipeline has agents representing a substantial array of treatment mechanisms and targets.

• Treatments
• Clinical Trials
• Digital Tools

Full summary, score breakdown and related studies → Original source

Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers

50/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: Significant PCs were further tested with other CSF NeuroToolKit (NTK) and imaging biomarkers. +3 more findings

• Biomarkers

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Phospho-specific plasma p-tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

Key finding: The novel plasma p-tau181 and p-tau231 assays did not show cross-reactivity. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Area Deprivation Index and Progression to Dementia (S2.007)

37/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: To investigate the association of the area deprivation index (ADI), as assigned at the census block group-level, with progression to dementia in cognitively unimpaired at baseline participants (≥50 years old) of the population-based Mayo Clinic Study of Aging (MCSA).

• Early Stage

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease Plasma Biomarkers Distinguish Clinical Diagnostic Groups in Memory Clinic Patients

49/100 ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders

Key finding: Several recent research studies show high performance of blood biomarkers to identify Alzheimer's disease also in the pre-dementia mild cognitive impairment (MCI) stage, but data from the routine clinical care memory clinic setting are needed.

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study

41/100 ✓ Peer-reviewed Risk factors Frontiers in neurology

Key finding: We observed suggestive evidence of risky effects of CHR on AMD (P = 0.0034), SS on AD (P = 0.0044), and INS on ALS (P = 0.0123). +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Multimer Detection System-Oligomerized Amyloid Beta (MDS-OAβ): A Plasma-Based Biomarker Differentiates Alzheimer's Disease from Other Etiologies of Dementia

41/100 ✓ Peer-reviewed Biomarkers International journal of Alzheimer's disease

Key finding: MDS-OAβ level was not significantly different between AD and mixed AD-VaD, but both groups were significantly different from the NCI/SCI and from the non-AD group.

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source