Newest studies

Plasma NT1-tau and Aβ42correlate with age and cognitive function in two large Down syndrome cohorts

49/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Here we asked whether ultrasensitive plasma immunoassays for a tau N-terminal fragment (NT1-tau) and Aβ isoforms predict cognitive impairment. +3 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Racial/Ethnic Differences in Risk Factors Associated With Severe COVID-19 Among Older Adults With ADRD

57/100 ✓ Peer-reviewed Disparities Journal of the American Medical Directors Association

Key finding: We found higher risks of COVID-19-related outcomes among Black and Hispanic individuals. +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cerebral small-vessel disease at high altitude: A comparison of patients from plateau and plain

50/100 ✓ Peer-reviewed Vascular contributions Frontiers in neurology

Key finding: A total of 169 patients in Tibet (high altitude) and 310 patients in Beijing (low altitude) were enrolled. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

41/100 ✓ Peer-reviewed Inflammation and the immune system Translational neurodegeneration

Key finding: In activated microglia, cholesterol enrichment promoted the release of encapsulated IL-1β accompanied by a switch to a more neuroprotective phenotype, with increased phagocytic capacity and release of neurotrophic factors. +4 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease

45/100 ✓ Peer-reviewed Treatments Clinical pharmacology and therapeutics

Key finding: Donanemab is an amyloid-targeting therapy that resulted in robust amyloid plaque reduction and slowed Alzheimer's disease (AD) progression compared with placebo in the phase II TRAILBLAZER-ALZ study (NCT03367403). +2 more findings

• Treatments
• Brain Biology
• Side Effects

Full summary, score breakdown and related studies → Original source

Burden of Illness Among Patients with Psychosis due to Dementia with Lewy Bodies and Other Dementias

33/100 ✓ Peer-reviewed Health systems and care delivery American Journal of Alzheimer s Disease & Other Dementias®

Key finding: Compared with patients with ODP, more patients with DLB had clinical events including anticholinergic effects, neurologic effects, and cognitive decline. +1 more finding

• Other Dementias
• Policy

Full summary, score breakdown and related studies → Original source

A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis

41/100 ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: In most cases, small vessel diseases are accompanied by cerebral hypoperfusion. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

41/100 ✓ Peer-reviewed Disease mechanisms Neuroscience

Key finding: In particular, intestinal microbial-derived metabolites have been associated with β-amyloid formation and brain amyloid deposition, tau phosphorylation, as well as neuroinflammation in AD patients. +3 more findings

• Brain Biology

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The Eye as a Diagnostic Tool for Alzheimer's Disease

41/100 ✓ Peer-reviewed Brain scans and imaging Life (Basel, Switzerland)

Key finding: While there are currently no disease-modifying agents capable of curing AD, early diagnosis and management in the preclinical stage can significantly improve patient morbidity and life expectancy. +1 more finding

• Diagnosis

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Protein fibril length in cerebrospinal fluid is increased in Alzheimer's disease

41/100 ✓ Peer-reviewed Tau biomarkers Communications biology

Key finding: Alzheimer's disease (AD) associated proteins exist in cerebrospinal fluid (CSF). +4 more findings

• Biomarkers
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Molecular mechanisms of ferroptosis and their involvement in brain diseases

40/100 ✓ Peer-reviewed Drug development Pharmacology & therapeutics

Key finding: Thus, a deep understanding of how ferroptosis contributes to these diseases, and how it can be modulated, can open a new window of opportunities for novel therapeutic strategies and targets. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

45/100 ✓ Peer-reviewed Brain scans and imaging Nature

Key finding: We found that mice with tauopathy but not those with amyloid deposition developed a unique innate and adaptive immune response and that depletion of microglia or T cells blocked tau-mediated neurodegeneration. +2 more findings

• Brain Biology

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Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology

58/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The MIND and Mediterranean diets are associated with less postmortem AD pathology, primarily β-amyloid load. +4 more findings

• Lifestyle
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sleep-Related Changes Prior to Cognitive Dysfunction

41/100 ✓ Peer-reviewed Risk factors Current neurology and neuroscience reports

Key finding: The aim of this review is to summarize the current evidence on the relationship between sleep and cognition and present available data reporting the impact that sleep alterations may have on cognitive functions.

• Lifestyle

Full summary, score breakdown and related studies → Original source

Association between Periodontal Disease and Cognitive Impairment in Adults

63/100 ✓ Peer-reviewed Inflammation and the immune system International journal of environmental research and public health

Key finding: All the included studies show evidence of an association between periodontitis and cognitive impairment or dementia and Alzheimer's disease pathology. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia

67/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Most neuroinflammatory CSF biomarkers were associated with WML in individuals without dementia. +4 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Abnormal plasma Aβ42/40 ratio identified older adult groups with lower memory scores, higher dementia risks, and higher ADRD biomarker levels, with potential implications for population screening. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma phosphorylated tau 217 in preclinical Alzheimer's disease

71/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: Higher baseline pTa u 217 levels were associated with worse cognitive trajectories ( β ^ p T a u × a g e = -0.07 (-0.09, -0.06), P < 0.001). +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Socioeconomic Deprivation, Genetic Risk, and Incident Dementia

68/100 ✓ Peer-reviewed Long-term cohort studies American journal of preventive medicine

Key finding: Socioeconomic factors and genetic predisposition are established risk factors for dementia. +3 more findings

• Risk Factors
• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma

50/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of hepatology

Key finding: & aims The immune landscape of hepatocellular carcinoma (HCC) following transarterial chemoembolisation (TACE) remains to be clarified. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist

55/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Blood-based biomarkers offer a major advance in the clinical evaluation of neurodegenerative diseases. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Pathways explaining racial/ethnic disparities in incident all-cause dementia among middle-aged US adults

50/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Compared with Non-Hispanic White (NHW) adults, Non-White adults had a higher incidence of AD-specific (hazard ratio [HR] = 2.05, 95% confidence interval [CI]: 1.21, 3.49) and all-cause dementia (HR = 2.01, 95% CI: 1.36, 2.98). +3 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer's disease: A systematic review and meta-analysis of animal studies

61/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology

Key finding: The analysis included 26 original articles describing (1050 rodents) with AD-like symptoms. +4 more findings

• Brain Biology

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Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies

63/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: Based on the title and abstracts, 830 papers were screened from which 250 primary research papers met the eligibility criteria (original research articles with patients or with a strict diabetes model without comorbidities, that included direct data about microglia in the brain or retina), and 17 additional research papers were included through forward and backward citations, resulting in a total of 267 primary research articles included in the scoping systematic review. +4 more findings

• Brain Biology
• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia

56/100 ✓ Peer-reviewed Long-term cohort studies Annals of neurology

Key finding: Delirium is a complex neurocognitive syndrome suspected to be bidirectionally linked to dementia. +3 more findings

Full summary, score breakdown and related studies → Original source