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72/100

✓ Peer-reviewed alzhub usefulness score 72 out of 100. Disparities

Topic: Risk, prevention and care in population studies

Importance Ischemic stroke is associated with increased risk of dementia, but the association of stroke severity and recurrence with risk of impaired cognition is not well known. Results At baseline, the mean (SD) age of participants was 54.1 (5.8) years, and 8485 of 15 379 participants (55.2%) were women. Compared with no stroke, risk of dementia by adjusted hazard ratio was 1.76 (95% CI, 1.49-2.00) for 1 minor to mild stroke, 3.47 (95% CI, 2.23-5.40) for 1 moderate to severe stroke, 3.48 (95% CI, 2.54-4.76) for 2 or more minor to mild strokes, and 6.68 (95% CI, 3.77-11.83) for 2 or more moderate to severe strokes. Conclusions and relevance In this study, risk of dementia significantly increased after ischemic stroke, independent of vascular risk factors. Results suggest a dose-response association of stroke severity and recurrence with risk of dementia.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Koton, S., Pike, JR., Johansen, M., Knopman, D. S., Lakshminarayan, K., Mosley, T., et al. (2022). Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study. JAMA neurology. https://doi.org/10.1001/jamaneurol.2021.5080

Vancouver

Koton S, Pike JR, Johansen M, Knopman DS, Lakshminarayan K, Mosley T, et al. Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study. JAMA neurology. 2022. doi:10.1001/jamaneurol.2021.5080. PMID: 35072712.

BibTeX

@article{koton2022-35072712,
  author  = {Koton, S. and Pike, JR. and Johansen, M. and Knopman, D. S. and Lakshminarayan, K. and Mosley, T. and Patole, S. and Rosamond, W. D. and others},
  title   = {{Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2021.5080},
  pmid    = {35072712},
  url     = {https://doi.org/10.1001/jamaneurol.2021.5080}
}

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Key findings

Importance Ischemic stroke is associated with increased risk of dementia, but the association of stroke severity and recurrence with risk of impaired cognition is not well known.
Results At baseline, the mean (SD) age of participants was 54.1 (5.8) years, and 8485 of 15 379 participants (55.2%) were women.
Compared with no stroke, risk of dementia by adjusted hazard ratio was 1.76 (95% CI, 1.49-2.00) for 1 minor to mild stroke, 3.47 (95% CI, 2.23-5.40) for 1 moderate to severe stroke, 3.48 (95% CI, 2.54-4.76) for 2 or more minor to mild strokes, and 6.68 (95% CI, 3.77-11.83) for 2 or more moderate to severe strokes.
Conclusions and relevance In this study, risk of dementia significantly increased after ischemic stroke, independent of vascular risk factors.
Results suggest a dose-response association of stroke severity and recurrence with risk of dementia.

Why it matters

This study found that the risk of dementia was significantly higher after an ischemic stroke, and that this risk increased with both the severity of the stroke and the number of strokes. This suggests that preventing strokes and their recurrence may help reduce the risk of developing dementia.

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Study details

Study designprospective cohort
Participants379
Effect size55.2%; 26.7%; 73.3%
Evidence strengthModerate

How this study scored 72/100

Published in a leading specialty journal, and it is a prospective cohort study, followed forward from enrollment. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A prospective cohort study, followed forward from enrollment
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	2 / 4	379 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 186 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	31.0 citations a year over 6 year(s) since 2022
Impact for its field and year	5 / 6	Cited 21.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 13 other studies in this library
Still being cited	3 / 4	Cited 147 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Rebecca F. Gottesman: h-index 92 (OpenAlex, whole career)
Institution's track record	3 / 3	National Institutes of Health: institution h-index 2,723 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 11 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35072712)
Free to read	0 / 2	Behind a paywall — scores zero
Total	72 / 100	—

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