Newest studies

Cognitive Reserve Modulates Brain Structure and Cortical Architecture in the Alzheimer's Disease

50/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: aMCI-HCR compared to aMCI-LCR patients showed significant decrease of CTh in the right temporal and in the left prefrontal lobe. +4 more findings

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Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder

57/100 ✓ Peer-reviewed Risk factors Journal of Parkinson's disease

Key finding: Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. +2 more findings

• Risk Factors
• Other Dementias
• Lifestyle

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Cardiovascular Risk Associated with Poorer Memory in Middle-Aged Adults from the Healthy Brain Project

55/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Higher number of CVRF was associated with poorer attention (β= -0.042, p = 0.039) and memory (β= -0.080, p < 0.001), but not with subjective cognitive function. +4 more findings

• Risk Factors

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The Parietal Lobe in Alzheimer's Disease and Blindness

41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Recent neuroimaging studies have revealed that some metabolic and perfusion impairments along with a reduction of the white and grey matter could take place in the parietal lobe during AD.

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An Overview on Sleep Medicine

41/100 ✓ Peer-reviewed Risk factors Advances in experimental medicine and biology

Key finding: Therefore, one of the fundamental pillars of health is sleeping an adequate number of hours, follow regular sleep-wake habits and identify sleep disorders. +4 more findings

• Risk Factors
• Lifestyle

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Sleep Disturbances, Cognitive Status, and Biomarkers of Dementia

57/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Prevalence of insomnia was 14%, 16%, and 11% for normal, MCI, and dementia groups. +4 more findings

• Lifestyle

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Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention

41/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

Key finding: Given the unknown therapeutic value of targeting Alzheimer's disease pathology and the discovery of robust risk factors for dementia, non-pharmacological risk reduction (RR) is increasingly offered as an alternative to targeting Alzheimer's disease pathology. +2 more findings

• Prevention

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An Argument for Simple Tests of Treatment of Alzheimer's Disease

41/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

Key finding: Two potential disease-modifying approaches for dementia are being vigorously tested: the early targeting of the neuropathology of Alzheimer's disease (AD) and multi-domain lifestyle interventions to promote resilience to neuropathology. +1 more finding

• Treatments

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Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer's Disease in the Absence of Memantine1

50/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD

Key finding: Patients treated with bryostatin pre-specified at Mini-Mental State Examination scores 10-14, without memantine, showed baseline balance, complete safety, and SIB improvements at 13 weeks with multiple imputation analysis: Study #203 = 4.1 SIB points above baseline (p = 0.005), and Study #202 = 4.2 SIB points above baseline (p = 0.016). +2 more findings

• Clinical Trials

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Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial

82/100 ✓ Peer-reviewed Clinical trials The Lancet. Neurology

Key finding: From May 13, 2015, to July 22, 2020, 185 participants with Down syndrome were assessed for eligibility and 160 (86%) were randomly assigned either memantine (n=81) or placebo (n=79). +4 more findings

• Clinical Trials
• Treatments
• Side Effects

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial

79/100 ✓ Peer-reviewed Clinical trials Journal of Alzheimer's disease : JAD

Key finding: Fosgonimeton and placebo were shown to be safe and well-tolerated across all doses. +4 more findings

• Clinical Trials

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Combinational Drug Repurposing from Genetic Networks Applied to Alzheimer's Disease

41/100 ✓ Peer-reviewed Drug development Journal of Alzheimer's disease : JAD

Key finding: It enables robust identification of signaling pathways enriched in disease susceptibility loci. +2 more findings

• Treatments

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Dysphagia Risk in Patients Prescribed Rivastigmine: A Systematic Analysis of FDA Adverse Event Reporting System

41/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: When compared to patients prescribed donepezil, galantamine, or memantine, individuals prescribed rivastigmine were almost twice as likely to report dysphagia as an adverse event. +4 more findings

• Treatments
• Side Effects

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Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease

41/100 ✓ Peer-reviewed Treatments CNS & neurological disorders drug targets

Key finding: Many drugs of different classes are being analyzed in the clinical trials and examined for their potency. +4 more findings

• Treatments

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Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice

41/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

Key finding: 3xTg mice exhibited nuanced deficits in RGC electrical signaling, axonal transport, and synaptic integrity that exceeded normal age-related decrements in RGC function in age- and sex-matched healthy control mice. +3 more findings

• Brain Biology

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Retinal Examinations Provides Early Warning of Alzheimer's Disease

41/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

Key finding: Current diagnostics for Alzheimer's disease are complex, unaffordable, and invasive without regard to diagnosis quality at early stages, which urgently calls for more technical improvements for diagnosis specificity. +4 more findings

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Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer

57/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

Key finding: We report that by early prion disease (50% timepoint), discrete fluorescent foci appeared adjacent to the optic disc. +2 more findings

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The New Era of Retinal Imaging in Hypertensive Patients

41/100 ✓ Peer-reviewed Brain scans and imaging Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Key finding: Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at the eye, heart, brain, and kidneys.

• Brain Scans
• Risk Factors

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Prospective Memory and Default Mode Network Functional Connectivity in Normal and Pathological Aging

41/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

Key finding: We found that the dementia groups showed worse PM performance and altered FC within the DMN as compared to the normal aging individuals. +2 more findings

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Single Nucleus Transcriptome Data from Alzheimer's Disease Mouse Models Yield New Insight into Pathophysiology

41/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD

Key finding: We identified several DEGs in both neuronal and glial cell subtypes in comparisons of wild type (WT) versus 5XFAD and WT versus T2KO mice, including Ttr, Fth1, Pcsk1n, Malat1, Rpl37, Rtn1, Sepw1, Uba52, Mbp, Arl6ip5, Gm26917, Vwa1, and Pgrmc1. +4 more findings

• Brain Biology

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Screening for Genetic Mutations Associated with Early-Onset Alzheimer's Disease in Han Chinese

52/100 ✓ Peer-reviewed Risk genes beyond APOE Current Alzheimer research

Key finding: We identified 7 functional variants in APP/PSENs in 8 patients, including 1 APP mutation (p. +4 more findings

• Genetics

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Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease

41/100 ✓ Peer-reviewed Risk genes beyond APOE Neural regeneration research

Key finding: The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form.

• Genetics

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TREM2 Gene Compound Heterozygosity in Neurodegenerative Disorders

48/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of Alzheimer's disease : JAD

Key finding: We identified a novel mutation c.401_406delinsTCTAT; p.(Asp134Valfs*55) in exon 3 of TREM2 in an Alzheimer's disease patient also carrying the p.Arg62His TREM2 variant. +2 more findings

• Genetics

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Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity

41/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD

Key finding: This has brought with it renewed attention on new methods which improve the accuracy of risk prediction. +4 more findings

• Genetics

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Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects

61/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease : JAD

Key finding: The established association of APOE*4 carriers with AD was confirmed in this community-based sample of older subjects (odds ratio (OR) = 2.22; p = 9.36E-14) and was stronger in females (OR = 2.72; p = 1.74E-10) than in males (OR = 1.88; p = 2.43E-05). +4 more findings

• Genetics
• Risk Factors

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