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Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI
Fardin Nabizadeh, Mohammad Balabandian, Mohammad Reza Rostami, Samuel Berchi Kankam, Fatemeh Ranjbaran, Mahsa Pourhamzeh, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Aging clinical and experimental research, 2022-02-28
Topic: Plasma and spinal-fluid biomarkers
Our findings demonstrated a significant association between plasma NFL levels and disrupted WM microstructure across the brain. In distinct areas, plasma NFL has a negative association with FA in the fornix, fronto-occipital fasciculus, corpus callosum, uncinate fasciculus, internal capsule, and corona radiata and a positive association with RD, AxD, and MD values in sagittal stratum, corpus callosum, fronto-occipital fasciculus, corona radiata, internal capsule, thalamic radiation, hippocampal cingulum, fornix, and cingulum. Lower FA and higher RD, AxD, and MD values are related to demyelination and degeneration in WM. Our findings revealed that the level of NFL in the blood is linked to WM alterations in MCI patients. Plasma NFL has the potential to be a biomarker for microstructural alterations. However, further longitudinal studies are necessary to validate the predictive role of plasma NFL in cognitive decline.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nabizadeh, F., Balabandian, M., Rostami, M. R., Kankam, S. B., Ranjbaran, F., & Pourhamzeh, M. (2022). Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI. Aging clinical and experimental research. https://doi.org/10.1007/s40520-022-02095-y
Vancouver
Nabizadeh F, Balabandian M, Rostami MR, Kankam SB, Ranjbaran F, Pourhamzeh M. Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI. Aging clinical and experimental research. 2022. doi:10.1007/s40520-022-02095-y. PMID: 35226303.
BibTeX
@article{nabizadeh2022-35226303,
author = {Nabizadeh, Fardin and Balabandian, Mohammad and Rostami, Mohammad Reza and Kankam, Samuel Berchi and Ranjbaran, Fatemeh and Pourhamzeh, Mahsa},
title = {{Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI}},
journal = {Aging clinical and experimental research},
year = {2022},
doi = {10.1007/s40520-022-02095-y},
pmid = {35226303},
url = {https://doi.org/10.1007/s40520-022-02095-y}
}
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Key findings
- Our findings demonstrated a significant association between plasma NFL levels and disrupted WM microstructure across the brain.
- In distinct areas, plasma NFL has a negative association with FA in the fornix, fronto-occipital fasciculus, corpus callosum, uncinate fasciculus, internal capsule, and corona radiata and a positive association with RD, AxD, and MD values in sagittal stratum, corpus callosum, fronto-occipital fasciculus, corona radiata, internal capsule, thalamic radiation, hippocampal cingulum, fornix, and cingulum.
- Lower FA and higher RD, AxD, and MD values are related to demyelination and degeneration in WM.
- Our findings revealed that the level of NFL in the blood is linked to WM alterations in MCI patients.
- Plasma NFL has the potential to be a biomarker for microstructural alterations.
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Study details
- Study designcross-sectional
- Participants92
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging clinical and experimental research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 92 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35226303) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
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