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Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study
Holland N, Malpetti M, Rittman T, Mak EE, Passamonti L, Kaalund SS, Hezemans FH, Jones PS et al.. Brain : a journal of neurology, 2022-03-01
Topic: Brain proteins, microglia and lab models
Brain regions with higher synaptic density are associated with a higher 18F-AV-1451 binding in progressive supranuclear palsy/corticobasal degeneration, but this association diminishes with disease severity.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Holland, N., Malpetti, M., Rittman, T., Mak, E. E., Passamonti, L., Kaalund, S. S., et al. (2022). Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study. Brain : a journal of neurology. https://doi.org/10.1093/brain/awab282
Vancouver
Holland N, Malpetti M, Rittman T, Mak EE, Passamonti L, Kaalund SS, et al. Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study. Brain : a journal of neurology. 2022. doi:10.1093/brain/awab282. PMID: 34398211.
BibTeX
@article{holland2022-34398211,
author = {Holland, N. and Malpetti, M. and Rittman, T. and Mak, E. E. and Passamonti, L. and Kaalund, S. S. and Hezemans, F. H. and Jones, P. S. and others},
title = {{Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study}},
journal = {Brain : a journal of neurology},
year = {2022},
doi = {10.1093/brain/awab282},
pmid = {34398211},
url = {https://doi.org/10.1093/brain/awab282}
}
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Key findings
- Brain regions with higher synaptic density are associated with a higher 18F-AV-1451 binding in progressive supranuclear palsy/corticobasal degeneration, but this association diminishes with disease severity.
Why it matters
In people with progressive supranuclear palsy or corticobasal degeneration, two tau-related brain diseases, brain regions with more synapses were linked to higher binding of the tau scan tracer 18F-AV-1451. This link weakened as the disease became more severe. The finding hints at how tau build-up and synapse loss relate over the course of these conditions, but the record gives few details.
Study details
- Study designcross-sectional
- Participants12
- Evidence strengthModerate
How this study scored 61/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 12 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 40 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.7 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 4.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author James Benedict Rowe: h-index 101 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Cambridge: institution h-index 1,973 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34398211) |
| Free to read | 2 / 2 | Free to read |
| Total | 61 / 100 | — |
What each of these 20 components measures, and what this score is not →
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