Newest studies

Trends in US Medicare Decedents' Diagnosis of Dementia From 2004 to 2017

52/100 ✓ Peer-reviewed Costs and economics JAMA health forum

Key finding: Among the included 3 515 329 Medicare fee-for-service decedents, when adjusted for age and sex, the percentage of older decedents with an ADRD diagnosis increased from 34.7% in 2004 to 47.2% in 2017. +4 more findings

• Policy
• Diagnosis

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Tailored, Community-Based Programs for People Living With Dementia and Their Family Caregiver

41/100 ✓ Peer-reviewed Caregiving Journal of gerontological nursing

Key finding: People living with dementia (PLWD) have voiced a desire to remain in their home environment as long as possible; unfortunately, there is limited integrated person-and family-centered community support. +4 more findings

• Caregiving

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Crossed cerebellar diaschisis in Alzheimer's disease

50/100 ✓ Peer-reviewed Drug development Nuclear medicine communications

Key finding: Comparison of SUVR in different brain regions demonstrated significant differences in the temporal, occipital and cerebellar cortices. +3 more findings

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Dual-Phase 18F-Florbetaben PET/CT: Unsuspected Thalamic Infarction Mimicking Alzheimer Disease

46/100 ✓ Peer-reviewed Brain scans and imaging Clinical nuclear medicine

Key finding: Dual-phase amyloid PET is considered a useful protocol to study patients with cognitive impairment. +4 more findings

• Brain Scans

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Overview of tau PET molecular imaging

41/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in neurology

Key finding: This article reviews tau PET imaging with an emphasis on first-generation and second-generation tau radiotracers and their application in neurodegenerative disorders, including Alzheimer's disease and non-Alzheimer's disease tauopathies. +4 more findings

• Brain Scans

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Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer's Disease

41/100 ✓ Peer-reviewed Tau biomarkers Cellular and molecular neurobiology

Key finding: Chronic neuroinflammation resulting from insufficient resolution is involved in the pathogenesis of AD and is associated with cognitive impairment. +3 more findings

• Biomarkers
• Early Stage

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Longitudinal Associations of Mental Disorders With Dementia: 30-Year Analysis of 1.7 Million New Zealand Citizens

50/100 ✓ Peer-reviewed Digital health tools JAMA psychiatry

Key finding: In this study, mental disorders were associated with the onset of dementia in the population. +2 more findings

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The economic burden of dementia in low- and middle-income countries (LMICs): a systematic review

74/100 ✓ Peer-reviewed Costs and economics BMJ global health

Key finding: The estimated costs of dementia in LMICs are lower than in high-income countries. +2 more findings

• Policy
• Health Equity

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Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings

71/100 ✓ Peer-reviewed Brain scans and imaging Translational psychiatry

Key finding: Meta-analyses revealed significant reductions in total sleep time, sleep efficiency, and percentage of slow-wave sleep (SWS) and rapid eye movement (REM) sleep, and increases in sleep latency, wake time after sleep onset, number of awakenings, and REM latency in AD compared to controls. +1 more finding

• Lifestyle

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Microglia regulation of synaptic plasticity and learning and memory

43/100 ✓ Peer-reviewed Brain scans and imaging Neural regeneration research

Key finding: These molecules released by microglia can lead to synaptic plasticity and learning and memory deficits associated with aging, Alzheimer's disease, traumatic brain injury, HIV-associated neurocognitive disorder, and other neurological or mental disorders such as autism, depression and post-traumatic stress disorder. +1 more finding

• Brain Biology
• Policy

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Dietary patterns in middle age: effects on concurrent neurocognition and risk of age-related cognitive decline

71/100 ✓ Peer-reviewed Prevention trials Nutrition reviews

Key finding: This systematic review demonstrated that adherence to the Mediterranean diet and other healthy dietary patterns in middle age can protect neurocognition later in life. +2 more findings

• Lifestyle

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CPNP 2022 Annual Meeting Poster Abstracts

39/100 ✓ Peer-reviewed Risk factors Mental Health Clinician

Key finding: A total of 11 case reports met criteria for inclusion. +4 more findings

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Practical Considerations in the Administration of Aducanumab for the Neurologist

35/100 ✓ Peer-reviewed Drug development Neurology. Clinical practice

Aducanumab (Aduhelm), developed by the biotechnology firm Biogen in Cambridge, MA, was approved using the less common accelerated approval pathway by the Federal Drug Administration (FDA) reserved for treatments that fill a significant unmet need. 1 Its approval on June 7, 2021, has been met with an outpouring of opinions from prescribers, insurers, advocacy groups, and hospital systems regarding its risk-benefit profile. 2-4 Originally approved for all forms of Alzheimer disease (AD), the FDA updated aducanumab's labeling on July 8, 2021, for "treatment in patients with mild cognitive impairment (MCI) or mild dementia stage of disease, the population in which treatment was initiated in clinical trials." 5 With 6 million people nationally in the United States who suffer from AD and an anticipated one-third of those who may now fulfill the criteria under the revised labeling, the implicat

• Treatments

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Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model

43/100 ✓ Peer-reviewed TREM2 and immune genetics Aging

Key finding: Increasing evidence has shown that exosomes from hypoxic pretreated adipose-derived stem cells (ADSCs) could be an effective cognitive function therapeutic in AD-associated pathophysiology. +3 more findings

• Brain Biology

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Epilepsy in neurodegenerative diseases

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Epileptic disorders : international epilepsy journal with videotape

Key finding: Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined. +3 more findings

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Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

71/100 ✓ Peer-reviewed Brain scans and imaging The Lancet. Neurology

Key finding: Although studies in animal models suggest that TREM2 is protective against Alzheimer's pathology, its effect on tau pathology and its potential beneficial role in people with Alzheimer's disease is still unclear. +3 more findings

• Biomarkers
• Genetics
• Brain Biology

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Association of Race and Ethnicity With Incidence of Dementia Among Older Adults

74/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: Dementia is a significant public health challenge and may have greater incidence among older adults from underrepresented racial and ethnic minority groups. +3 more findings

• Health Equity
• Risk Factors

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Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment

70/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: These findings suggest that this blood biomarker test could allow for distinguishing individuals with brain amyloid-positive PET findings from individuals with amyloid-negative PET findings and serve as an aid for Alzheimer disease diagnosis. +3 more findings

• Biomarkers
• Brain Scans

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New insights into the genetic etiology of Alzheimer's disease and related dementias

77/100 ✓ Peer-reviewed Genetics Nature Genetics

Key finding: 111,326 cases/proxy-cases vs 677,663 controls analyzed +3 more findings

• Genetics

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Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in medicine

Key finding: As multiple preclinical and clinical research studies highlight gut microbiota's potential to modulate the general state of health state, it goes without saying that gut microbiota plays a significant role in neurogenesis, mental and cognitive development, emotions, and behaviors, and in the progression of neuropsychiatric illnesses.

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Principles and philosophies for speech and language therapists working with people with primary progressive aphasia: an international expert consensus

48/100 ✓ Peer-reviewed Digital health tools Disability and rehabilitation

Key finding: This study describes the philosophy of expert practice and outlines a set of best practice principles when working with people with PPA.Implications for rehabilitationPrimary progressive aphasia (PPA) describes a group of language led dementias which deteriorate inexorably over time. +1 more finding

• Other Dementias

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Association of Brain Volumes and White Matter Injury With Race, Ethnicity, and Cardiovascular Risk Factors: The Multi-Ethnic Study of Atherosclerosis

60/100 ✓ Peer-reviewed Disparities Journal of the American Heart Association

Key finding: We found no statistically significant difference in measures of WM injury by race and ethnicity after adjustment for cardiovascular risk factors and socioeconomic status. +4 more findings

• Risk Factors
• Health Equity
• Brain Scans

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Retraction: High-Affinity Naloxone Binding to Filamin A Prevents Mu Opioid Receptor-Gs Coupling / Retraction: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling (among five Wang-authored papers retracted)

12/100 ⚠ Retracted — do not rely on it Laboratory science PLOS ONE

Key finding: Five PLOS ONE papers by Hoau-Yan Wang and colleagues retracted on March 30, 2022 +4 more findings

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Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients

76/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: We identified that combining plasma p-tau217 and a brief cognitive composite score was strongly related to greater risk of progression to AD dementia in MCI patients, suggesting that these measures could be key components of future prognostic algorithms for early AD. +1 more finding

• Early Stage
• Biomarkers

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Progression to Dementia or Reversion to Normal Cognition in Mild Cognitive Impairment as a Function of Late-Onset Neuropsychiatric Symptoms

61/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Late-onset NPS improve the specificity of MCI as an at-risk state for progression to dementia. +3 more findings

• Early Stage

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