Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,626–21,650 of 27,380 studies, newest first · page 866 of 1096.
February 2009 25
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2009-02-06
Reducing between scanner differences in multi-center PET studies
49/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: Two correction steps were developed by comparison of 3-D Hoffman brain phantom scans with the 'gold standard' digital 3-D Hoffman brain phantom: i) high frequency correction; where a smoothing kernel for each scanner model was estimated to smooth all images to a common resolution and ii) low frequency correction; where smooth affine correction factors were obtained to reduce the attenuation and scatter correction errors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-05
Keeping In Touch Everyday (KITE) project: developing assistive technologies with people with dementia and their carers to promote independence
36/100 ✓ Peer-reviewed Clinical safety International psychogeriatrics
Key finding: Prototypes for two devices (armband and electronic notepad) were developed. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-05
Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
58/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: The fornix is a predominant outflow tract of the hippocampus and may be an important indicator of AD progression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-05
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's BMC genomics
Key finding: In general, there was only a moderate alteration of gene expression in ADAM10 overexpressing mice. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-05
Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions
44/100 ✓ Peer-reviewed Digital health tools Acta neuropathologica
Key finding: The total frequency of asymmetric motor disturbances (e.g., parkinsonism, pyramidal signs, and contracture) during the course was significantly more frequent in FTLD-TDP (78%) than in Pick's disease cases (14%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-04
Dying from cancer or other chronic diseases in the Netherlands: ten-year trends derived from death certificate data
52/100 ✓ Peer-reviewed End-of-life care BMC palliative care
Key finding: Further investments to facilitate dying at home are desirable. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-04
Mild cognitive impairment and everyday function: an investigation of driving performance
45/100 ✓ Peer-reviewed Clinical safety Journal of geriatric psychiatry and neurology
Key finding: Participants with MCI demonstrated significantly lower performance than controls on ratings of global and discrete driving maneuvers, but these differences were not at the level of frank impairments. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-03
Racial/ethnic disparities in medication use among veterans with hypertension and dementia: a national cohort study
59/100 ✓ Peer-reviewed Disparities The Annals of pharmacotherapy
Key finding: Adherence rates for a number of antihypertensive and dementia drugs are lower for minorities compared with whites. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-03
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese
49/100 ✓ Peer-reviewed Genetics Genomics
Key finding: A case-control study demonstrated that 36 of these SNPs exhibited significance after adjustment for multiple testing. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-02
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America
Key finding: Most significantly, this loss of surface IRs, and ADDL-induced oxidative stress and synaptic spine deterioration, could be completely prevented by insulin. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-02 month only
Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients
77/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: AD patients aged 50-85 years were randomized to open-label treatment with oral rivastigmine, donepezil or galantamine for 13 weeks. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
45/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: Here we identify the cellular prion protein (PrP(C)) as an amyloid-beta-oligomer receptor by expression cloning. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US
40/100 ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry
Key finding: The MoCA appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings, varying ethnic groups, and younger at-risk individuals.
Full summary, score breakdown and related studies → Original source
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2009-02-01
Mitochondrial dysfunction and glaucoma
36/100 ✓ Peer-reviewed Brain scans and imaging Journal of glaucoma
Key finding: Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying increasing age as a risk factor for glaucoma is not well understood. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease
43/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
10/100 ⚠ Retracted — do not rely on it Risk genes beyond APOE Nature
Key finding: Our results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2009-02-01
Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly
47/100 ✓ Peer-reviewed Biomarkers Annals of neurology
Key finding: Reduction in CSF Abeta(42), likely reflecting Abeta aggregation in the brain, is associated with brain atrophy in the preclinical phase of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Chronic exposure to stress results in a reduction of hippocampal neurogenesis and of hippocampal volume. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Challenges for professional care of advanced dementia
43/100 ✓ Peer-reviewed End-of-life care International journal of nursing practice
Key finding: Responses emphasized the need for improved knowledge and skills, and clearer policy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Delirium and long-term cognitive impairment
47/100 ✓ Peer-reviewed Clinical safety International review of psychiatry (Abingdon, England)
Key finding: In addition to these well-established adverse consequences, there is increasing evidence linking delirium and a higher risk of long-term cognitive impairment (LTCI), including dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Rapidly progressive neurodegenerative dementias
47/100 ✓ Peer-reviewed Disease mechanisms Archives of neurology
Key finding: Based on this cohort, although CJD is the most likely cause of a rapidly progressive neurodegenerative dementia, frontotemporal lobar degeneration with motor neuron degeneration, diffuse Lewy body disease, tauopathies, and Alzheimer disease can also cause a rapidly progressive dementia.
Full summary, score breakdown and related studies → Original source
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2009-02-01
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice
56/100 ✓ Peer-reviewed Inflammation and the immune system Science (New York, N.Y.)
Key finding: Using multiphoton fluorescence lifetime imaging microscopy in vivo, we quantitatively imaged astrocytic calcium homeostasis in a mouse model of Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Patterns of chronic multimorbidity in the elderly population
64/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: In persons with multimorbidity, there exists co-occurrence of diseases beyond chance, which clinicians need to take into account in their daily practice. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-02-01
Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial
72/100 ✓ Peer-reviewed Risk factors Diabetes care
Key finding: A statistically significant age-adjusted association was observed between the A1C level and the score on all four cognitive tests. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-02-01
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
54/100 ✓ Peer-reviewed Risk factors Nature genetics
Key finding: Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, collectively referred to as synucleinopathies, are associated with a diverse group of genetic and environmental susceptibilities.
Full summary, score breakdown and related studies → Original source
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