Newest studies

Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study

57/100 ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

Key finding: CSF C1q and C3b, as well as plasma C2 and C3, were elevated in symptomatic mutation carriers compared to presymptomatic carriers and non-carriers. +4 more findings

• Biomarkers
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer's disease

50/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the International Neuropsychological Society : JINS

Key finding: Overall, the results suggest that ARC is reliable and valid and represents a feasible tool for assessing cognitive changes associated with the earliest stages of AD. +3 more findings

• Diagnosis
• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants

70/100 ✓ Peer-reviewed Prevention and risk Biological Psychiatry

Key finding: The negative association between depression treatment and incident dementia was significant in the increasing and chronically low courses, highlighting the necessity of timely interventional strategies before depression progresses to a chronically severe state. +3 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease

41/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica communications

Key finding: Recently, we found that all proteins required for necroptosis execution, a previously defined programmed form of neuronal cell death, are present in GVD, such as the phosphorylated necroptosis executioner mixed-lineage kinase domain-like protein (pMLKL). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models

41/100 ✓ Peer-reviewed Drug development Neuropeptides

Key finding: Traumatic brain injury (TBI), characterized by acute neurological impairment, is associated with a higher incidence of neurodegenerative diseases, particularly chronic traumatic encephalopathy (CTE), Alzheimer's disease (AD), and Parkinson's disease (PD), whose hallmarks include hyperphosphorylated tau protein. +2 more findings

• Brain Biology
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Providers' Perspectives on High-Quality Dementia Care in Long-Term Care

41/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: The 9 participants described the importance of understanding the experiences of PLWDs in order to provide high-quality dementia care and to deliver such care with the residents and their preferences as the focus. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Optimal anti-amyloid-beta therapy for Alzheimer's disease via a personalized mathematical model

45/100 ✓ Peer-reviewed Treatments PLoS computational biology

Key finding: With the recent approval by the FDA of the first disease-modifying drug for Alzheimer's Disease (AD), personalized medicine will be increasingly important for appropriate management and counseling of patients with AD and those at risk.

• Treatments
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The therapeutic potential of TREM2 in cancer

41/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in oncology

Key finding: However, expansion of TREM2 research into the field of cancer has revealed that epithelial tumor cells as well as intratumoral macrophages and myeloid regulatory cells also express TREM2. +1 more finding

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

48/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset in sporadic Alzheimer's disease (AD). +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Enteric nervous system and intestinal epithelial regulation of the gut-brain axis

41/100 ✓ Peer-reviewed Disease mechanisms The Journal of allergy and clinical immunology

Key finding: This interplay provides a link between exogenous environmental stimuli such as nutrient sensing, and nervous system function, as well as a mechanism of feedback from cortical and sensory centers of the brain to enteric activities. +4 more findings

Full summary, score breakdown and related studies → Original source

Ethics of digital therapeutics (DTx)

41/100 ✓ Peer-reviewed Prevention and risk European review for medical and pharmacological sciences

Key finding: Today, there are roughly 35 to 40 products on the market, 8 of which approved by regulatory agencies. +4 more findings

• Digital Tools
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double-blind, randomized, placebo-controlled exploratory clinical trial

79/100 ✓ Peer-reviewed Clinical trials International journal of geriatric psychiatry

Key finding: Compared with placebo, the amino acid mixture did not improve NPI-12, MMSE, TMT-A and B or CDR scores. +3 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Artificial intelligence in dementia

41/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in ophthalmology

Key finding: Artificial intelligence tools are being rapidly integrated into clinical environments and may soon be incorporated into dementia diagnostic paradigms. +4 more findings

• Digital Tools

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A literature review of hypertensive retinopathy: systemic correlations and new technologies

41/100 ✓ Peer-reviewed Brain scans and imaging European review for medical and pharmacological sciences

Key finding: HR signs have a significative association with cardiovascular, cerebrovascular and other systemic diseases. +4 more findings

• Digital Tools
• Risk Factors

Full summary, score breakdown and related studies → Original source

Abnormal characterization of dynamic functional connectivity in Alzheimer's disease

55/100 ✓ Peer-reviewed Brain scans and imaging Neural regeneration research

Key finding: We found differences in dynamic function connectivity strength in the left precuneus, default mode network, and dorsal attention network among normal controls, aMCI patients, and AD patients.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood DNA Methylation Patterns in Older Adults With Evolving Dementia

48/100 ✓ Peer-reviewed Genetics The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Reflecting this, epigenetic alterations have been associated with each of these processes, especially at the level of DNA methylation, and such changes may help explain the observed interindividual variability in the development of the 2 pathologies. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

43/100 ✓ Peer-reviewed Treatments Frontiers in neuroscience

Key finding: GLP-1 mimetics are currently on the market as treatments for type 2 diabetes. +4 more findings

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Post‐acute care transitions and outcomes among Medicare beneficiaries with dementia: Associations with race/ethnicity and dual status

41/100 ✓ Peer-reviewed Risk factors Health Services Research

Key finding: Dual-related differences were significantly larger than race/ethnicity differences in PAC transitions. +4 more findings

• Health Equity
• Policy

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Evaluating The Accuracy Of Medicare Risk Adjustment For Alzheimer’s Disease And Related Dementias

45/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs

Key finding: Among those with ADRD HCCs, 34 percent did not have clinician-adjudicated disease. +4 more findings

• Policy

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Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

47/100 ✓ Peer-reviewed Inflammation and the immune system Cells

Key finding: Cerebral atrophy, amyloid-β (Aβ) plaques, and neurofibrillary tangles represent the main pathological hallmarks of the AD brain. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study

47/100 ✓ Peer-reviewed Long-term cohort studies JAMA cardiology

Key finding: Cholesteryl ester transfer protein inhibition (CETP) has been shown to increase levels of high-density lipoprotein cholesterol (HDL-C) and reduce levels of low-density lipoprotein cholesterol (LDL-C). +3 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Association of Multimorbidity, Disease Clusters, and Modification by Genetic Factors With Risk of Dementia

67/100 ✓ Peer-reviewed Long-term cohort studies JAMA network open

Key finding: Individual conditions have been identified as risk factors for dementia; however, it is important to consider the role of multimorbidity, as conditions often co-occur. +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source

Social participation and mild cognitive impairment in low- and middle-income countries

66/100 ✓ Peer-reviewed Risk factors Preventive medicine

Key finding: In the overall sample, after adjustment for potential confounders, a one-unit increase in the social participation score was associated with a 13% decrease in odds for MCI (OR = 0.87; 95%CI = 0.82-0.93). +1 more finding

• Early Stage
• Health Equity

Full summary, score breakdown and related studies → Original source

Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases

41/100 ✓ Peer-reviewed Genetics International journal of molecular sciences

Key finding: The human APOE gene is polymorphic with three major alleles, ε2, ε3 and ε4, encoding apoE2, apoE3, and apoE4, respectively. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Global, regional, and national trends of dementia incidence and risk factors, 1990-2019: A Global Burden of Disease study

47/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The declining incidence of dementia in some countries, despite growing prevalence, is encouraging and urges further investigation. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source