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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Inflammation and the immune system

Reviewed as evidence on: Clonal hematopoiesis (blood-cancer-linked mutations) and AD risk / microglial inflammation 2 studies (what the news said). Being listed means the study bears on the question, not that it agrees with the news.

Topic: Brain proteins, microglia and lab models

Purpose Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18 F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer's disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ-) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer's disease pathophysiology. Accordingly, we investigated associations between 18 F-THK5351 PET positivity and cognitive decline among Aβ- aMCI patients. Materials and methods The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups: 18 F-THK5351-positive and -negative groups. The present study used a linear mixed effects model to estimate the effects of 18 F-THK5351 PET positivity on cognitive prognosis among Aβ- aMCI patients. Results Among the 25 Aβ- aMCI patients, 10 (40.0%) were 18 F-THK5351 positive. The patients in the 18 F-THK5351-positive group were older than those in the 18 F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p 18 F-THK5351-positive group deteriorated at a faster rate than those of the 18 F-THK5351-negative group (B=0.003, p =0.033). Conclusion The results of the present study suggest that increased 18 F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ- aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).

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APA 7th

Chun, M. Y., Lee, J., Jeong, J. H., Roh, J. H., Oh, S. J., Oh, M., et al. (2022). 18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment. Yonsei medical journal. https://doi.org/10.3349/ymj.2022.63.3.259

Vancouver

Chun MY, Lee J, Jeong JH, Roh JH, Oh SJ, Oh M, et al. 18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment. Yonsei medical journal. 2022. doi:10.3349/ymj.2022.63.3.259. PMID: 35184428.

BibTeX

@article{chun2022-35184428,
  author  = {Chun, M. Y. and Lee, J. and Jeong, J. H. and Roh, J. H. and Oh, S. J. and Oh, M. and Oh, J. S. and others},
  title   = {{18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment}},
  journal = {Yonsei medical journal},
  year    = {2022},
  doi     = {10.3349/ymj.2022.63.3.259},
  pmid    = {35184428},
  url     = {https://doi.org/10.3349/ymj.2022.63.3.259}
}

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Key findings

Purpose Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18 F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer's disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ-) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer's disease pathophysiology.
Results Among the 25 Aβ- aMCI patients, 10 (40.0%) were 18 F-THK5351 positive.
Conclusion The results of the present study suggest that increased 18 F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ- aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).

Why it matters

In 25 people with amnestic mild cognitive impairment but no amyloid on brain scans, 10 (40.0%) were positive on 18F-THK5351 PET, a scan whose signal may reflect neuroinflammation as well as tau. That group was older and deteriorated at a faster rate over follow-up than the scan-negative group. The authors suggest increased uptake on this scan might be a useful predictor of a poorer outlook in such patients, possibly linked to increased neuroinflammation.

Study details

Study designclinical trial
Participants25
Effect size40.0%
Evidence strengthLow

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Yonsei medical journal)
Journal's citation record	1 / 4	Yonsei Medical Journal: journal h-index 96 (OpenAlex, 2026-10-29)
Study design	0 / 12	Design recorded as “clinical trial”, which our rubric does not rank (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	1 / 4	25 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 6 year(s) since 2022
Impact for its field and year	1 / 6	Cited 0.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Sang Won Seo: h-index 47 (OpenAlex, whole career)
Institution's track record	1 / 3	Sungkyunkwan University: institution h-index 788 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 9 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 35184428)
Free to read	2 / 2	Free to read
Total	41 / 100	—

What each of these 20 components measures, and what this score is not →

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