Home › Research › Inflammation and the immune system
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease
Bairamian D, Sha S, Rolhion N, Sokol H, Dorothée G, Lemere CA, Krantic S.. Molecular neurodegeneration, 2022-03-05
Topic: Amyloid, tau and blood-test diagnosis
Background The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept. Accumulating data suggest that the gut microbiota exert its action at least in part by modulating neuroinflammation. Given the link between neuroinflammatory changes and neuronal activity, it is plausible that gut microbiota may affect neuronal functions indirectly by impacting microglia, a key player in neuroinflammation.
Key findings
- Accumulating data suggest that the gut microbiota exert its action at least in part by modulating neuroinflammation.
- Given the link between neuroinflammatory changes and neuronal activity, it is plausible that gut microbiota may affect neuronal functions indirectly by impacting microglia, a key player in neuroinflammation.
- Indeed, increasing evidence suggests that interplay between microglia and synaptic dysfunction may involve microbiota, among other factors.
- In addition to these indirect microglia-dependent actions of microbiota on neuronal activity, it has been recently recognized that microbiota could also affect neuronal activity directly by stimulation of the vagus nerve.
Why it matters
This review suggests that gut microbiota may affect brain function indirectly by influencing microglia and neuroinflammation, which could in turn affect synapses. These ideas are still emerging and no treatment or prevention for Alzheimer's disease is established here.
Study details
- Evidence strengthLow
How this study scored 56/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular neurodegeneration) |
| Journal's citation record | 2 / 4 | Molecular Neurodegeneration: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 315 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 52.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 18.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 4 / 4 | Cited 232 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Slavica M Krantic: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35248147) |
| Free to read | 2 / 2 | Free to read |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13024-022-00522-2
- PubMed: 35248147
- Original source →
- Free full text: Molecular Neurodegeneration →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Bairamian, D., Sha, S., Rolhion, N., Sokol, H., Dorothée, G., Lemere, C. A., et al. (2022). Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease. Molecular neurodegeneration. https://doi.org/10.1186/s13024-022-00522-2
Vancouver
Bairamian D, Sha S, Rolhion N, Sokol H, Dorothée G, Lemere CA, et al. Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease. Molecular neurodegeneration. 2022. doi:10.1186/s13024-022-00522-2. PMID: 35248147.
BibTeX
@article{bairamian2022-35248147,
author = {Bairamian, D. and Sha, S. and Rolhion, N. and Sokol, H. and Dorothée, G. and Lemere, C. A. and Krantic, S.},
title = {{Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease}},
journal = {Molecular neurodegeneration},
year = {2022},
doi = {10.1186/s13024-022-00522-2},
pmid = {35248147},
url = {https://doi.org/10.1186/s13024-022-00522-2}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 28.
Later studies that cite this one
7 studies in the alzhub library list this one in their references.
Related studies in Inflammation and the immune system
Also in Inflammation and the immune system
138 studies in the library are filed under Inflammation and the immune system with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Inflammation and the immune system hub.