Newest studies

Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years - United States, 2019

16/100 ⚠ Report — not peer-reviewed Risk factors MMWR. Morbidity and mortality weekly report

Key finding: Adults with subjective cognitive decline (SCD), § an early indicator of possible future ADRD (4), were more likely to report four or more risk factors than were those without SCD (34.3% versus 13.1%). +1 more finding

• Risk Factors
• Prevention

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Biological mechanisms and possible primary prevention of depression

41/100 ✓ Peer-reviewed Prevention and risk World journal of psychiatry

Key finding: Individuals with unipolar depressive disorder (UDD) are having an increased risk of death and development of dementia in later life.

• Prevention

Full summary, score breakdown and related studies → Original source

Assessment of Cognitive Reserve using Near Infrared Spectroscopy

41/100 ✓ Peer-reviewed Risk factors Journal of analytical techniques and research

Key finding: FMRI studies indicate that frontoparietal network plays an important role in cognitive reserve. +1 more finding

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Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

41/100 ✓ Peer-reviewed Genetics Scientific reports

Key finding: Using recent Alzheimer's disease (AD) GWAS results as the base data, we determined each individual's polygenic risk score (PRS) in the UK Biobank dataset. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

[Therapy Developments in Alzheimer's Disease]

30/100 ✓ Peer-reviewed Drug development Fortschritte der Neurologie-Psychiatrie

Key finding: Research is being conducted into more potent therapies for symptomatic treatment, particularly for behavioral disturbances, but also into drugs that intervene in the pathophysiology of the disease, with the aim of halting or at least slowing the progression of the disease. +3 more findings

• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Medicare spending associated with a dementia diagnosis among older adults

55/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: Among the diagnosis cohort, mean (SD) overall spending was $4773 ($9774) per quarter - 43% of which was spending on hospital care ($2048). +4 more findings

• Policy
• Diagnosis

Full summary, score breakdown and related studies → Original source

Association of Long-term Exposure to Ambient Air Pollution With Cognitive Decline and Alzheimer's Disease-Related Amyloidosis

66/100 ✓ Peer-reviewed Risk factors Biological psychiatry

Key finding: Long-term exposure to PM 2.5 contributed to the development of cognitive decline, which may be partly explained by brain amyloid accumulation indicative of increased AD risk.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Role of Aducanumab in the Treatment of Alzheimer's Disease: Challenges and Opportunities

43/100 ✓ Peer-reviewed Treatments Clinical interventions in aging

Key finding: This decision has generated a considerable debate in the scientific community, especially because the results from the two Phase 3 trials, EMERGE and ENGAGE, were divergent and, even after the post hoc analysis, the data were insufficient to prove aducanumab efficacy. +1 more finding

• Treatments
• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Deep Learning-Based Diagnosis of Alzheimer's Disease

47/100 ✓ Peer-reviewed Digital health tools Journal of personalized medicine

Key finding: Deep learning techniques have been reported to be more accurate for AD diagnosis in comparison to conventional machine learning models. +4 more findings

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

58/100 ✓ Peer-reviewed Biomarkers Nature reviews. Neurology

Key finding: Blood biomarkers of adequate effectiveness have the potential to act as first-line diagnostic and prognostic tools, and offer the possibility of extensive population screening and use that is not limited to specialized centres. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Genome-wide association studies for Alzheimer's disease: bigger is not always better

45/100 ✓ Peer-reviewed Genetics Brain communications

Key finding: We highlight potential caveats this situation creates and discuss some of the consequences occurring when translating the newest Alzheimer's disease genome-wide association study results into basic research and/or clinical practice.

• Genetics

Full summary, score breakdown and related studies → Original source

Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy

43/100 ✓ Peer-reviewed Digital health tools Light, science & applications

Key finding: Using the UFF-PAM system, we have demonstrated proof-of-concept studies on the mouse brains in response to systemic hypoxia, sodium nitroprusside, and stroke. +1 more finding

• Brain Scans

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Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study

47/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: Clear divergence in tauopathy between the sexes are apparent approximately 20 years earlier than previously reported. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum

56/100 ✓ Peer-reviewed Brain scans and imaging Radiology

Key finding: Among patients with cognitive symptoms, larger choroid plexus volume was associated with severity of cognitive impairment in the Alzheimer disease spectrum. +4 more findings

• Brain Scans
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Alzheimer disease neuropathology in a patient previously treated with aducanumab

57/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica

Key finding: In the LTE, Amyloid PET scans demonstrated robust Aβ plaque reduction, from a composite standard uptake value ratio (SUVR) of 1.5 at screening to < 1.1 at 56 weeks post-aducanumab dosing. +4 more findings

• Brain Biology
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

83/100 ✓ Peer-reviewed Risk factors American journal of human genetics

Key finding: Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology

55/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Aβ(+) patients with TES (N = 10), but not Aβ(-) TES, had significantly higher plasma P-tau levels than HC (P-tau181: p d = 1.34; P-tau217: p d = 1.59). +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia

64/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: A combination of plasma p-tau181, NfL, and GFAP, but not Aβ 1-42/1-40 , might be useful to discriminate AD, FTD, and DLB.

• Biomarkers
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Microbiota-gut-brain axis in the Alzheimer's disease pathology - an overview

41/100 ✓ Peer-reviewed Disease mechanisms Neuroscience research

Key finding: Along with genetic factors, environmental factors, and aging also increase the risks of developing neurodegenerative disorders. +4 more findings

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Diagnostic and prognostic performance to detect Alzheimer's disease and clinical progression of a novel assay for plasma p-tau217

59/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

Key finding: Our results indicate good diagnostic and prognostic performance of the plasma p-tau217+ Janssen assay, similar to the p-tau217 Lilly assay. +1 more finding

• Diagnosis
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

46/100 ✓ Peer-reviewed Prevention and risk Journal of neuroinflammation

Key finding: High-fat diet had a wider array of metabolic, cognitive, and neuropathological consequences in AD and MxD females compared to males. +3 more findings

• Brain Biology
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Dementia Neuropsychiatric Symptom Frequency, Severity, and Correlates in Community-Dwelling Thai Older Adults

46/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: NPS frequency varied from 18% for appetite and/or eating changes to 42% for delusions. +4 more findings

• Caregiving

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Impact of cerebral blood flow and amyloid load on SUVR bias

52/100 ✓ Peer-reviewed Brain scans and imaging EJNMMI research

Key finding: Despite high correlations (GCA: R2 ≥ 0.85), large overestimation and proportional bias of SUVR relative to DVR was observed. +4 more findings

Full summary, score breakdown and related studies → Original source

Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis

43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Alterations to cognitive abilities and functional networks in rats post broad-band intense noise exposure

41/100 ✓ Peer-reviewed Brain scans and imaging Brain imaging and behavior

Key finding: The deficit in spatial learning/memory was only observed at 6 months after noise exposure. +4 more findings

Full summary, score breakdown and related studies → Original source