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Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons
Takayuki Kondo, Tsuyoshi Yamamoto, Kaoru Okayama, Hideki Narumi, Haruhisa Inoue. Scientific reports, 2022-03-02
Topic: Gut, metabolism and diet
Microbial flora is investigated to be related with neuropathological conditions in Alzheimer's disease (AD), and is attracting attention as a drug discovery resource. However, the relevance between the soil microbiota and the pathological condition has not been fully clarified due to the difficulty in isolation culture and the component complexity. In this study, we established a library of secondly metabolites produced in microorganism to investigate the potential effect of microorganisms on the production of amyloid β (Aβ), one of the most representative pathogens of AD. We conducted a library screening to quantify Aβ and neuronal toxicity by using cortical neurons from human induced pluripotent stem cells (iPSCs) of AD patients after adding secondary metabolites. Screening results and following assessment of dose-dependency identified Verrucarin A, produced in Myrothecium spp., showed 80% decrease in Aβ production. Furthermore, addition of Mer-A2026A, produced in Streptomyces pactum, showed increase in Aβ42/40 ratio at the low concentration, and decrease in Aβ production at the higher concentration. As a result, established library and iPSC-based phenotyping assay clarified a direct link between Aβ production and soil microorganisms. These results suggest that Aβ-microorganism interaction may provide insight into the AD pathophysiology with potential therapeutics.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kondo, T., Yamamoto, T., Okayama, K., Narumi, H., & Inoue, H. (2022). Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons. Scientific reports. https://doi.org/10.1038/s41598-022-06513-z
Vancouver
Kondo T, Yamamoto T, Okayama K, Narumi H, Inoue H. Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons. Scientific reports. 2022. doi:10.1038/s41598-022-06513-z. PMID: 35236875.
BibTeX
@article{kondo2022-35236875,
author = {Kondo, Takayuki and Yamamoto, Tsuyoshi and Okayama, Kaoru and Narumi, Hideki and Inoue, Haruhisa},
title = {{Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons}},
journal = {Scientific reports},
year = {2022},
doi = {10.1038/s41598-022-06513-z},
pmid = {35236875},
url = {https://doi.org/10.1038/s41598-022-06513-z}
}
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Key findings
- Screening results and following assessment of dose-dependency identified Verrucarin A, produced in Myrothecium spp., showed 80% decrease in Aβ production.
- As a result, established library and iPSC-based phenotyping assay clarified a direct link between Aβ production and soil microorganisms.
- These results suggest that Aβ-microorganism interaction may provide insight into the AD pathophysiology with potential therapeutics.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific reports) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35236875) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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