Newest studies

Brain MRI Analysis for Alzheimer's Disease Diagnosis Using CNN-Based Feature Extraction and Machine Learning

51/100 ✓ Peer-reviewed Digital health tools Sensors (Basel, Switzerland)

Key finding: In addition, based on official records, cases of death from Alzheimer's disease have increased significantly. +1 more finding

• Digital Tools
• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Roles of physical activity and diet in cognitive aging: is more better?

61/100 ✓ Peer-reviewed Prevention and risk The Clinical neuropsychologist

Key finding: There was a significant interaction between PASE and MIND on executive functioning and total grey matter volume. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging

59/100 ✓ Peer-reviewed Vascular contributions Frontiers in aging neuroscience

Key finding: In this cross-sectional study, we found higher kW values in the cerebral cortex (mean = 81.51 min-1, SD = 15.54) compared to cerebral white matter (mean = 75.19 min-1, SD = 13.85) (p < 0.0001). +3 more findings

Full summary, score breakdown and related studies → Original source

Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases

41/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: Emerging evidence suggests that both disruption of circadian rhythms and gut dysbiosis are closely related to aging-associated neurodegenerative diseases. +1 more finding

Full summary, score breakdown and related studies → Original source

Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective

55/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD) differ by world region, suggesting that there are potentially modifiable risk factors for intervention.

• Prevention

Full summary, score breakdown and related studies → Original source

Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in immunology

Key finding: Increasing documentation suggests that the microbiota-gut-brain axis not only impacts brain cognition and psychiatric symptoms but also precipitates neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review and Meta-Analysis

63/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in aging neuroscience

Key finding: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no cure, and available treatments are only able to postpone the progression of the disease. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Early dementia diagnosis, MCI-to-dementia risk prediction, and the role of machine learning methods for feature extraction from integrated biomarkers, in particular for EEG signal analysis

49/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: On clinical data, this innovative approach for early diagnosis might provide more insight into pathophysiological processes underlying degenerative changes, as well as toward a personalized risk evaluation for pharmacological, nonpharmacological, and rehabilitation treatments.

• Early Stage
• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Quantification of amyloid PET for future clinical use: a state-of-the-art review

54/100 ✓ Peer-reviewed Caregiving European journal of nuclear medicine and molecular imaging

Key finding: The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission tomography (PET), for which three fluorine-18 labelled radiotracers have been approved for clinical use. +1 more finding

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

National Coverage Determination: Monoclonal Antibodies Directed Against Amyloid for the Treatment of Alzheimer's Disease (NCD 200.3)

10/100 ⚠ Regulatory decision — not a study Treatments Centers for Medicare & Medicaid Services

Key finding: NCD effective April 7, 2022; requires clinical diagnosis of MCI or mild AD dementia with confirmed amyloid pathology +2 more findings

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS

41/100 ✓ Peer-reviewed Vascular contributions Circulation research

Key finding: We observe a 3.71-fold increase in BACE1 expression in the cerebral microvessels from patients with hypertension. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases

41/100 ✓ Peer-reviewed Drug development Drug discovery today

Key finding: Taken together, these findings will shed new light on exploiting more repurposed small-molecule drugs targeting different types of toxic proteins to fight NDs in the future.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database

61/100 ✓ Peer-reviewed Brain scans and imaging Scientific reports

Key finding: Metadata alone proved to be more effective in explaining the variance in the sample (20.4%) versus fundus images (9.3%) alone. +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non‐Latino White older adults in Northern California

56/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Among non-Latino Whites, ADI was associated with dementia incidence (most vs. least disadvantaged ADI quintile HR = 1.09, 95% confidence interval [CI] = 1.02-1.15). +3 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

40/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: It is a process that causes neuronal damage and occurs in various pathways. +4 more findings

• Brain Biology

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Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers

43/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: In the 115 years since the discovery of Alzheimer's disease (AD), our knowledge, diagnosis, and therapeutics have significantly improved.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Attention-Guided Hybrid Network for Dementia Diagnosis With Structural MR Images

38/100 ✓ Peer-reviewed Long-term cohort studies IEEE transactions on cybernetics

Key finding: As it is practically challenging to capture local and subtle disease-associated abnormalities directly from the whole-brain sMRI, most of those deep-learning approaches empirically preselect disease-associated sMRI brain regions for model construction. +3 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants

61/100 ✓ Peer-reviewed Long-term cohort studies PLoS medicine

Key finding: Women's reproductive factors have been associated with the risk of dementia; however, these findings remain uncertain. +3 more findings

• Risk Factors

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The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease

41/100 ✓ Peer-reviewed Disease mechanisms Molecular therapy : the journal of the American Society of Gene Therapy

Key finding: Increased ADAM10 activity promoted synaptic plasticity, as revealed by changes in the molecular compositions of synapses and the spine morphology. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Early-stage Alzheimer disease: getting trial-ready

53/100 ✓ Peer-reviewed Treatments Nature reviews. Neurology

Key finding: A new clinical trials infrastructure is required to increase the efficiency of recruitment and accelerate therapeutic progress. +4 more findings

• Treatments
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease

40/100 ✓ Peer-reviewed Genetics Neuron

Key finding: To improve understanding of transcriptomic heterogeneity in glia during AD, we used single-nuclei RNA sequencing (snRNA-seq) to characterize astrocytes and oligodendrocytes from apolipoprotein (APOE) Ɛ2/3 human AD and age- and genotype-matched non-symptomatic (NS) brains. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

A Time-to-Event Exposure-Response Model for Amyloid-Related Imaging Abnormalities Following Administration of Aducanumab to Subjects With Early Alzheimer Disease

35/100 ✓ Peer-reviewed Drug development Journal of clinical pharmacology

Key finding: ARIA-E incidence has been observed to be dependent on both dose and apolipoprotein E4 carrier status. +3 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

New insights into the genetic etiology of Alzheimer's disease and related dementias

66/100 ✓ Peer-reviewed Mild cognitive impairment Nature genetics

Key finding: We found 75 risk loci, of which 42 were new at the time of analysis. +1 more finding

• Genetics

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American Indian and Alaska Native veterans in the Indian Health Service: Health status, utilization, and cost

42/100 ✓ Peer-reviewed Health systems and care delivery PloS one

Key finding: We employed logistic, linear, or negative binomial regressions as appropriate, by sex and overall. +3 more findings

• Policy

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Sleep apnea and the risk of dementia: A systematic review and meta-analysis

70/100 ✓ Peer-reviewed Prevention and risk Journal of Sleep Research

Key finding: Patients with sleep apnea had an increased risk of developing any type of neurocognitive disorder (HR: 1.43 [95% CI 1.26-1.62]), Alzheimer's disease (HR: 1.28 [95% CI 1.16-1.41]), and Parkinson's disease (HR: 1.54 [95% CI 1.30-1.84]). +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source