Newest studies

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

52/100 ✓ Peer-reviewed How common it is The Lancet Public Health

Key finding: Global dementia cases projected to rise from 57.4 million (2019) to 152.8 million (2050), a 166% increase +3 more findings

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Genetics of common cerebral small vessel disease

41/100 ✓ Peer-reviewed Genetics Nature reviews. Neurology

Key finding: Advances in technologies and collaborative work have led to substantial progress in the identification of common genetic variants that are associated with cSVD-related stroke (ischaemic and haemorrhagic) and MRI-defined covert cSVD. +2 more findings

• Genetics
• Other Dementias

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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

40/100 ✓ Peer-reviewed Disease mechanisms Clinical microbiology reviews

Key finding: Recent publications have highlighted that an imbalance in the gut microflora, known as dysbiosis, is associated with the onset and progression of neurological disorders. +1 more finding

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Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators

41/100 ✓ Peer-reviewed Genetics ACS medicinal chemistry letters

Key finding: Furthermore, mechanistic studies into GWAS-linked variants suggest that disease protection is attributed to the alternative splicing of exon 2 of the CD33 pre-mRNA. +1 more finding

• Genetics

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Memory care reduces nursing home admissions among assisted-living residents with dementia

45/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Residents in memory-care assisted living had a lower adjusted risk of hospitalization (risk difference = -1.8 percentage points [P = .014], hazard ratio = 0.93 [0.87-1.00]), a lower risk of nursing-home admission (risk difference = -2.2 percentage points [P < .001], hazard ratio = 0.87 [-.79-0.95]), and a lower risk of a long-term nursing home admission (risk difference = -1.1 percentage points [P < .001], hazard ratio = 0.71 [0.57-0.88]). +1 more finding

• Care Services

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International consensus on the use of tau PET imaging agent 18F-flortaucipir in Alzheimer's disease

41/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

Key finding: This international consensus and practice guideline will help to promote the standardized use of 18F-flortaucipir PET in patients with AD. +1 more finding

• Brain Scans

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Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study

51/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The association of testosterone concentrations with dementia risk remains uncertain. +3 more findings

• Risk Factors

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New Drug Update: Dostarlimab, Loncastuximab Tesirine, and Aducanumab

39/100 ✓ Peer-reviewed Treatments The Senior Care Pharmacist

Key finding: Dostarlimab (Jemperli®) is FDA-indicated for the treatment of adult patients with mismatch repair deficient (dMMR - an abnormality that affects DNA repair) recurrent or advanced endometrial cancer (EC). +4 more findings

• Treatments

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Fluorescent Aptasensor and Colorimetric Aptablot for p-tau231 Detection: Toward Early Diagnosis of Alzheimer’s Disease

39/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: Owing to their advantages, which include affordability, rapidity, high sensitivity, and dependence on complicated instruments, these aptamer-based biosensors offer significant potential for the early diagnosis of AD worldwide.

• Biomarkers
• Diagnosis

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Periodontal Disease and Risk of Dementia in Medicare Patients with Hepatitis C Virus

45/100 ✓ Peer-reviewed Costs and economics Journal of Alzheimer's disease : JAD

Key finding: Of 439,760 HCV patients, the incidence rate of ADRD was higher in patients with periodontal diseases compared to those without (10.84% versus 9.26%, p < 0.001), and those with periodontal disease developed ADRD earlier compared to those without periodontal disease (13.99 versus 21.60 months, p < 0.001). +2 more findings

• Policy
• Risk Factors

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Advance care planning in neurologic illness

41/100 ✓ Peer-reviewed End-of-life care Handbook of clinical neurology

Key finding: Research has shown that engaging in early ACP leads to greater goal-concordant care in advanced neurologic illness and affects end-of-life medical decision-making.

• End-of-Life Care

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Prognostication in dementia

41/100 ✓ Peer-reviewed End-of-life care Handbook of clinical neurology

Key finding: In this chapter, we discuss the trajectory of dementia and its variability, markers associated with poorer prognosis (such as poor nutrition, pneumonia, comorbid conditions), the impact of hospitalization on prognosis, and current models of end-of-life palliative care/hospice eligibility (with the use of the Functional Assessment Staging tool and other markers).

• End-of-Life Care

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Exploring the Relationship between Falls in Long Term Care and Psychoactive Prescribing

41/100 ✓ Peer-reviewed Health systems and care delivery The Journal of frailty & aging

Key finding: Falls have associated significant morbidity and mortality, and a proportion of falls can be deemed avoidable. +1 more finding

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Association of Dementia Severity and Caregiver Support With Early Discharge From Home Health

45/100 ✓ Peer-reviewed Caregiving American journal of Alzheimer's disease and other dementias

Key finding: The final cohort consisted of 91 302 Medicare beneficiaries with an ADRD diagnosis. +4 more findings

• Caregiving
• Care Services

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Patterns of Mixed Pathologies in Down Syndrome

41/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer's disease : JAD

Key finding: Tau and amyloid-β pathology was prevalent in all cases and compatible with that typically seen in AD with some subtle deviations. +4 more findings

• Brain Biology

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Cerebrospinal Fluid Biomarkers for Cerebral Amyloid Angiopathy Diagnosis

41/100 ✓ Peer-reviewed Vascular contributions Journal of Alzheimer's disease : JAD

Key finding: An accurate diagnosis of sporadic cerebral amyloid angiopathy (CAA) is critical for patient management and research (including clinical trials) for this common small vessel pathology of the brain. +4 more findings

• Biomarkers
• Diagnosis

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Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer's Disease

41/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

Key finding: Recent evidence suggests that several systemic changes outside the brain are associated with AD and may contribute to its pathogenesis.

• Brain Biology

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Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review

63/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

Key finding: Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. +2 more findings

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Diet Patterns, the Gut Microbiome, and Alzheimer's Disease

41/100 ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

Key finding: Emerging data suggest that the fungal microbiota (mycobiome) may also influence AD pathology.

• Brain Biology
• Lifestyle

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The Gut Microbiome and Alzheimer's Disease: A Growing Relationship

41/100 ✓ Peer-reviewed Disease mechanisms Current Alzheimer research

Key finding: Furthermore, bacteria populating the gut microbiota can secrete large amounts of amyloid proteins and lipopolysaccharides, which modulate signaling pathways and alter the production of proinflammatory cytokines associated with the pathogenesis of Alzheimer's disease.

• Brain Biology

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Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk

41/100 ✓ Peer-reviewed Disease mechanisms Gut microbes

Key finding: Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer's disease (AD). +3 more findings

• Brain Biology

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Neurotoxicity of Diesel Exhaust Particles

41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: DEP exposure at 100μg/m3 for 5 h, but not lower doses, caused oxidative damage, complement and microglia activation in cerebral cortex and corpus callosum. +3 more findings

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Perceived Stress in Older Dementia Caregivers: Mediation by Loneliness and Depression

41/100 ✓ Peer-reviewed Risk factors American journal of Alzheimer's disease and other dementias

Key finding: Using multiple mediation analyses, we found that loneliness and depression mediated the relationship of caregiver status with perceived stress.

• Caregiving
• Lifestyle

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[Physical Activity and Mental Health in the Elderly]

41/100 ✓ Peer-reviewed Risk factors Praxis

Key finding: Physical fitness is associated with better mental health in the elderly. +1 more finding

• Lifestyle

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Quantitative MRI Evidence for Cognitive Reserve in Healthy Elders and Prodromal Alzheimer's Disease

57/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: We observed significant differences in the association between CR and white matter tract MTV in aMCI versus HC when age, gender, intracranial volume, and memory ability were held constant. +3 more findings

• Early Stage

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