Newest studies

Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease

64/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Family history (FH) of late-onset Alzheimer's disease (AD) is associated with changes in several cerebrospinal fluid (CSF) biomarkers in cognitively normal individuals. +1 more finding

• Biomarkers

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Brain-age is associated with progression to dementia in memory clinic patients

55/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroImage. Clinical

Key finding: Biomarkers for the early detection of dementia risk hold promise for better disease monitoring and targeted interventions. +3 more findings

• Care Services

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Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-β-Amyloid Immunotherapy: A Meta-analysis

69/100 ✓ Peer-reviewed Drug development Neurology

Key finding: The PubMed and Embase databases were searched for clinical trials of anti-Aβ immunotherapy published on or before January 12, 2022. +3 more findings

• Clinical Trials
• Side Effects
• Brain Scans

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Influence of genetic and cardiometabolic risk factors in Alzheimer's disease

41/100 ✓ Peer-reviewed Risk factors Ageing research reviews

Key finding: These potential risk factors associated with cerebral metabolic changes which fuel AD pathogenesis have been suggested to be the reason for the disappointing clinical trial results.

• Risk Factors
• Genetics

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Head-to-Head Comparison of Different Blood Collecting Tubes for Quantification of Alzheimer's Disease Biomarkers in Plasma

52/100 ✓ Peer-reviewed Biomarkers Biomolecules

Key finding: We found that plasma collected in Li-Hep and Na-Hep tubes yielded significantly higher tau and p-tau181 levels compared to plasma collected in K2-EDTA tubes from the same person, but there was no difference in the measured values of the Aβ40, Aβ42, and Aβ42/40 ratio.

• Biomarkers

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Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy

49/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of hematology & oncology

Key finding: However, despite over 40% of cancer patients being eligible to receive immunotherapy, only 12% of patients gain benefit. +3 more findings

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Documenting the need for teaching resourcefulness skills to family caregivers

55/100 ✓ Peer-reviewed Caregiving Applied nursing research : ANR

Key finding: Caregivers differed significantly on caregiver burden (F = 2.46; p = .014) and resourcefulness (F = 2.08; p = .038). +4 more findings

• Caregiving

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Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease

45/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: Similar results were obtained upon injection of extracellular vesicles carrying Aβ naturally secreted by CHO7PA2 cells, while neither Aβ42 alone nor inflammatory extracellular vesicles devoid of Aβ were able to propagate long-term potentiation impairment.

• Brain Biology

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Alzheimer's disease, cerebrovascular disease and dementia: lump, split or integrate?

45/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology

Key finding: This scientific commentary refers to ‘Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline’ by Rabin et al.

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Unifying framework for cognitive training interventions in brain aging

40/100 ✓ Peer-reviewed Prevention trials Ageing research reviews

Key finding: Cognitive training is a promising tool for slowing or preventing cognitive decline in older adults at-risk for dementia. +4 more findings

• Lifestyle

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Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)

51/100 ✓ Peer-reviewed Tau biomarkers EBioMedicine

Key finding: The apolipoprotein E (APOE)ε4 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (CSF) of total tau (t-tau), phosphorylated tau (p-tau), and amyloid-β (Aβ). +3 more findings

• Biomarkers
• Genetics
• Brain Biology

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Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice

43/100 ✓ Peer-reviewed TREM2 and immune genetics Neuropharmacology

Key finding: Neuroinflammation secondary to surgery and anesthesia is strongly correlated with POCD. +3 more findings

• Brain Biology
• Genetics

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Role of Aβ in Alzheimer's-related synaptic dysfunction

41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cell and developmental biology

Key finding: Besides, extracellular glutamate accumulation induced by Aβ mediates synapse toxicity resulting from reduced glutamate receptors and glutamate spillovers. +4 more findings

• Brain Biology

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Diet, Gut Microbiome, and Cognitive Decline

41/100 ✓ Peer-reviewed Disease mechanisms Current nutrition reports

Key finding: An epidemic of age-associated cognitive decline, most commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's disease, is causing healthcare costs to soar and devastating caregivers. +4 more findings

• Genetics
• Lifestyle

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Progression of Subjective Cognitive Decline to MCI or Dementia in Relation to Biomarkers for Alzheimer Disease: A Meta-analysis

68/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: The risk of mild cognitive impairment (MCI) or dementia in individuals with subjective cognitive decline (SCD) and biomarkers indicating Alzheimer disease (AD) pathology in comparison with individuals with SCD without biomarker evidence for AD is critical to delineate the potential role of biomarker assessment in this group. +3 more findings

• Early Stage
• Biomarkers

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The inter-relationship between delirium and dementia: the importance of delirium prevention

59/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Neurology

Key finding: People with dementia have a higher risk of developing delirium than the general population, and the occurrence of delirium is an independent risk factor for subsequent development of dementia.

• Prevention
• Risk Factors

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Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia

65/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Impaired spatial navigation was associated with conversion to dementia within 2 and 4 years and with key CSF and MRI biomarkers for AD and neurodegeneration in patients with SCD and MCI. +4 more findings

• Biomarkers
• Brain Scans
• Early Stage

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Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults

59/100 ✓ Peer-reviewed Prevention trials Frontiers in psychology

Key finding: Participants reporting having played a musical instrument across three life periods (n = 70) were compared to controls without a history of musical instrument playing (n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. +1 more finding

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Multi-feature computational framework for combined signatures of dementia in underrepresented settings

48/100 ✓ Peer-reviewed Digital health tools Journal of neural engineering

Key finding: The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers. +4 more findings

• Brain Scans
• Health Equity

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Microglial Activation and Connectivity in Alzheimer Disease and Aging

54/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: Microglial activation distributes preferentially along highly connected brain regions, similar to tau pathology. +4 more findings

• Brain Scans
• Brain Biology

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Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper

62/100 ✓ Peer-reviewed Cognitive tests and assessment EP Europace

Key finding: Atrial fibrillation (AF) is the most common clinical arrhythmia with substantial health and socioeconomic impact on healthcare.1 The number of people affected by this condition was estimated to be 33.5 million in 2010, with an increasing prevalence and incidence over the coming years.2 In 2017, there were 37.6 million [95% confidence interval (CI): 32.5–42.6 million] individuals with AF/atrial flutter globally.3 The estimated number of subjects with AF in 2030 in Europe will be 14–17 million, and the number of new cases of AF per year at 120 000–215 000.4 Atrial fibrillation is independently associated with increased mortality and morbidity from complications such as ischaemic stroke, dementia, and cognitive dysfunction.5 Oral anticoagulation can significantly reduce the risk of stroke, dementia, and death.6 As a part of a holistic or integrated approach to AF care, it is associated with improved outcomes7–9 and is advocated in guidelines.10,11 In many patients, AF can be asymptomatic, and the diagnosis is established after the appearance of a complication typically associated with AF, such as ischaemic stroke/systemic embolic or heart failure. +4 more findings

• Diagnosis

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Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

41/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response.

• Brain Biology

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Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles

48/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology

Key finding: Global Aβ and tau-PET standardized uptake value ratios (SUVRs) were plotted for all patients and outliers, and patients with abnormally low SUVRs compared to the biomarker-classic cohort were identified. +1 more finding

• Brain Scans
• Biomarkers

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Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2

50/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: TYROBP is expressed in numerous cell types, including peripheral blood monocytes, macrophages, dendritic cells, and osteoclasts, but a key point of recent interest is related to the critical role played by TYROBP in the function of many receptors expressed on the plasma membrane of microglia. +3 more findings

• Genetics
• Brain Biology

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Validation of the Computerized Cognitive Assessment Test: NNCT

41/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of environmental research and public health

Key finding: This test aims to digitize cognitive assessments to add greater accessibility than classic tests, as well as to present results in real time and reduce costs. +2 more findings

• Diagnosis

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