alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 21,026–21,050 of 27,380 studies, newest first · page 842 of 1096.

January 2010 25

  1. 2010-01-15

    AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

    ✓ Peer-reviewed Disease mechanisms Journal of Biological Chemistry

    Key finding: These data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.

    Full summary, score breakdown and related studies → Original source

  2. 2010-01-15

    Associating genes and protein complexes with disease via network propagation

    ✓ Peer-reviewed Risk factors PLoS computational biology

    Key finding: We test our method on gene-disease association data, evaluating both the prioritization achieved and the protein complexes inferred. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2010-01-15

    Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden

    ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

    Key finding: Patients with early age-of-onset Alzheimer's disease show more rapid progression, more generalized cognitive deficits and greater cortical atrophy and hypometabolism compared to late-onset patients at a similar disease stage. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2010-01-14

    Pathological roles of MAPK signaling pathways in human diseases

    ✓ Peer-reviewed Inflammation and the immune system Biochimica et biophysica acta

    Key finding: The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2010-01-14

    Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease

    ✓ Peer-reviewed Hippocampus size on brain scans AJNR. American journal of neuroradiology

    Key finding: All biomarkers were sensitive to the diagnostic group. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2010-01-13

    Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

    ✓ Peer-reviewed Inflammation and the immune system The Journal of biological chemistry

    Key finding: The glial accumulation of alpha-synuclein through the transmission of the neuronal protein was also demonstrated in a transgenic mouse model expressing human alpha-synuclein. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2010-01-13

    Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

    ✓ Peer-reviewed Hippocampus size on brain scans Schizophrenia research

    Key finding: Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.

    Full summary, score breakdown and related studies → Original source

  8. 2010-01-12

    Antipsychotic use and the risk of hip fracture among older adults afflicted with dementia

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: APs appear to increase the risk of hip fracture among older adults with dementia residing in an NH. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2010-01-12

    A nuclear factor-binding domain in the 5'-untranslated region of the amyloid precursor protein promoter: implications for the regulation of gene expression

    ✓ Peer-reviewed Down syndrome and Alzheimer's BMC research notes

    Key finding: The 5' untranslated region (UTR) of the APP gene, encompassing 147 base pairs between the transcriptional (+1) and the translational start site, was examined for its role in APP expression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2010-01-12

    Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

    ✓ Peer-reviewed How common it is BMJ (Clinical research ed.)

    Key finding: Angiotensin receptor blockers are associated with a significant reduction in the incidence and progression of Alzheimer's disease and dementia compared with angiotensin converting enzyme inhibitors or other cardiovascular drugs in a predominantly male population. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2010-01-11

    Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters

    ✓ Peer-reviewed Brain scans and imaging NeuroImage

    Key finding: The results indicated favorable performance of the RVM and identified the number of training samples as the critical factor for prediction accuracy.

    Full summary, score breakdown and related studies → Original source

  12. 2010-01-11

    Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

    ✓ Peer-reviewed Lewy body dementia The Journal of clinical investigation

    Key finding: In vivo expression of the mutated PAC transgene in the mouse reproduced the endogenous Notch3 expression pattern and main pathological features of CADASIL, including Notch3 extracellular domain aggregates and granular osmiophilic material (GOM) deposits in brain vessels, progressive white matter damage, and reduced cerebral blood flow. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2010-01-07

    Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics

    ✓ Peer-reviewed Brain tissue and pathology The Journal of Physical Chemistry B

    Key finding: Amyloid fibrils represent a stable form of many misfolded proteins associated with numerous diseases. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2010-01-07

    Cigarette Smoking is a Risk Factor for Alzheimer's Disease: An Analysis Controlling for Tobacco Industry Affiliation

    ✓ Peer-reviewed Prevention and risk Journal of Alzheimer s Disease

    Key finding: Using random effects meta-analysis, 18 case control studies without tobacco industry affiliation yielded a non-significant pooled odds ratio of 0.91 (95% CI, 0.75-1.10), while 8 case control studies with tobacco industry affiliation yielded a significant pooled odds ratio of 0.86 (95% CI, 0.75-0.98) suggesting that smoking protects against AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2010-01-07

    The cholinergic system and Parkinson disease

    ✓ Peer-reviewed Lewy body dementia Behavioural brain research

    Key finding: Non-motor comorbidities, such as cognitive impairment, are likely the result of an intricate interplay of multi-system degenerations and neurotransmitter deficiencies extending beyond the loss of dopaminergic nigral neurons. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2010-01-07

    Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on MRI: the evaluation of vascular care in Alzheimer's disease (EVA) study

    ✓ Peer-reviewed Treatments Stroke

    Key finding: Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2010-01-05

    Mild hypoxia enhances proliferation and multipotency of human neural stem cells

    ✓ Peer-reviewed Biomarkers PloS one

    Key finding: These findings raise the possibility that reduced oxygen levels occurring in neuronal disorders like cerebral ischemia transiently lead to NSC remaining in a state of quiescence. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2010-01-05

    Ageing, neurodegeneration and Parkinson's disease

    ✓ Peer-reviewed Risk factors Age and ageing

    Key finding: Mild parkinsonian signs may be present in older people, which are associated with reduced function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2010-01-05

    Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

    ✓ Peer-reviewed Biomarkers Neuroscience letters

    Key finding: Thus our results suggest that PTEN delocalized from the nucleus to the cytoplasm and to intracellular NFTs may cause a deregulation of PI3K pathway in the cytoplasm and may induce the nuclear dysfunction of PTEN in AD degenerating neurons.

    Full summary, score breakdown and related studies → Original source

  20. 2010-01-01

    Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

    ✓ Peer-reviewed Vascular contributions Frontiers in Neuroenergetics

    Key finding: Many studies have investigated the mechanisms of neurovascular regulation in arterioles but other evidence suggests that blood flow regulation can also occur in capillaries, because of the presence of contractile cells, pericytes, on the capillary wall. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2010 year only

    Dementia care 1: Person centred approaches help to promote effective communication

    ✓ Peer-reviewed Health systems and care delivery Nursing times

    Key finding: Three types of communication were identified: staff to staff, staff to resident, and staff to family. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2010 year only

    ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients

    ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Significantly elevated mean levels of total ERK1/2 and pERK1/2 were found in the CJD patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2010-01-01

    Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD

    Key finding: The most significant risk factor in AD is advanced age and an important neuropathological correlate of AD is the deposition of amyloid-beta peptide (Abeta40 and Abeta42) in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2010-01-01

    Metabotropic glutamate receptors: physiology, pharmacology, and disease

    ✓ Peer-reviewed Risk factors Annual review of pharmacology and toxicology

    Key finding: The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2010-01-01

    HMGB1 and RAGE in inflammation and cancer

    ✓ Peer-reviewed Risk factors Annual review of immunology

    Key finding: High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein, released actively following cytokine stimulation as well as passively during cell death; it is the prototypic damage-associated molecular pattern (DAMP) molecule and has been implicated in several inflammatory disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →