Newest studies

Alzheimer's Disease CSF Biomarker Profiles in Idiopathic Normal Pressure Hydrocephalus

48/100 ✓ Peer-reviewed Tau biomarkers Journal of personalized medicine

Key finding: Nevertheless, the clinical meaning of these findings has not been fully explained. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model

55/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: Upon further refinement and validation, the VWD model could inform strategies for dosing and ARIA monitoring in individuals with an ARIA-E history.

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease

66/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology

Key finding: As a result, blood-based biomarkers are increasingly being sought as alternatives. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Association of neighborhood socioeconomic disadvantage and cognitive impairment

57/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: In cognitively unimpaired (CU) adults at baseline, the risk for progression to dementia increased for every decile increase in the ADI state ranking (hazard ratio = 1.06, 95% confidence interval (1.01-1.11), P = .01). +4 more findings

• Risk Factors
• Early Stage
• Health Equity

Full summary, score breakdown and related studies → Original source

A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study

54/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These results revealed a universal applicability of the "A/T/N" framework in a Chinese population and established an optimal diagnostic model consisting of cost-effective and non-invasive approaches for diagnosing AD. +1 more finding

• Biomarkers
• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

The burden and risks of emerging complications of diabetes mellitus

65/100 ✓ Peer-reviewed Caregiving Nature reviews. Endocrinology

Key finding: Additionally, studies have demonstrated notable links between diabetes mellitus and a broad range of comorbidities, including cognitive decline, functional disability, affective disorders, obstructive sleep apnoea and liver disease, and have refined our understanding of the association between diabetes mellitus and infection.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series

55/100 ✓ Peer-reviewed Biomarkers Journal of neurotrauma

Key finding: In addition, hippocampal sclerosis was a common neuropathological comorbidity ( n = 5) and associated with limbic-predominant TDP-43 proteinopathy ( n = 4) or FTLD-TDP ( n = 1).

• Biomarkers

Full summary, score breakdown and related studies → Original source

Transfer learning for cognitive reserve quantification

54/100 ✓ Peer-reviewed Risk factors NeuroImage

Key finding: The current findings suggest that the transfer learning approach is an effective way to generalize the residual-based CR estimation.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr 682 phosphorylated APP βCTF

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science advances

Key finding: Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down Syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lysosomal v-ATPase and acidification. +3 more findings

• Down Syndrome
• Digital Tools

Full summary, score breakdown and related studies → Original source

18F-MK-6240 tau-PET in genetic frontotemporal dementia

45/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: Tau is one of several proteins associated with frontotemporal dementia. +4 more findings

• Brain Scans
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease

71/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. +2 more findings

Full summary, score breakdown and related studies → Original source

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

51/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: Recent studies have identified TREM2 as a risk factor for Alzheimer's disease (AD). +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS

41/100 ✓ Peer-reviewed Drug development PloS one

Key finding: Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. +4 more findings

• Treatments
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees

41/100 ✓ Peer-reviewed Genetics Epigenetics

Key finding: It has revealed that some tissues age faster than others, which is vital to understanding the complex phenomenon of ageing and developing effective interventions. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk: A Mendelian Randomization Study

64/100 ✓ Peer-reviewed Drug development Neurology

Key finding: Genetic variation in sulfonylurea targets was associated with a lower risk of AD, and future studies are warranted to clarify the underlying mechanistic pathways between sulfonylureas and AD. +4 more findings

• Treatments
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

40/100 ✓ Peer-reviewed Brain scans and imaging Nature biotechnology

Key finding: Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent and durable silencing in the central nervous system (CNS), eye and lung in rodents and non-human primates with broad cell type specificity. +4 more findings

Full summary, score breakdown and related studies → Original source

Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

47/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience

Key finding: Autolysosome acidification declines in neurons well before extracellular amyloid deposition, associated with markedly lowered vATPase activity and build-up of Aβ/APP-βCTF selectively within enlarged de-acidified autolysosomes.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuroinflammation in Vascular Cognitive Impairment and Dementia: Current Evidence, Advances, and Prospects

50/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

Key finding: It is caused by long-term chronic low perfusion in the whole brain or local brain area, and it eventually develops into severe cognitive dysfunction syndrome. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting

48/100 ✓ Peer-reviewed Digital health tools NPJ Parkinson's disease

Key finding: Tau aggregates were significantly elevated in PSP patients compared to all other groups (sensitivity 87%, specificity 70%, AUC 0.76). +3 more findings

• Digital Tools
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Global estimates on the number of persons across the Alzheimer's disease continuum

60/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature.

Full summary, score breakdown and related studies → Original source

Providing informal care to a person living with dementia: the experiences of informal carers in Australia

41/100 ✓ Peer-reviewed Caregiving Archives of gerontology and geriatrics

Key finding: Recordings of the interviews were transcribed verbatim and analysed using an inductive approach (thematic analysis) which revealed strong narratives from informal carers regarding (1) available support, (2) the health impacts of caring, (3) new roles and responsibilities, and (4) the motivations around caring.

• Caregiving

Full summary, score breakdown and related studies → Original source

Neuropathology of Dementia Disorders

41/100 ✓ Peer-reviewed Brain tissue and pathology Continuum (Minneapolis, Minn.)

Key finding: This article provides an overview of the neuropathology of common age-related dementing disorders, focusing on the pathologies that underlie Alzheimer disease (AD) and related dementias, including Lewy body dementias, frontotemporal dementia, vascular dementia, limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy (LATE), and mixed-etiology dementias. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents

41/100 ✓ Peer-reviewed Drug development Computational and structural biotechnology journal

Key finding: Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value.

• Treatments

Full summary, score breakdown and related studies → Original source

TREM2 coding variants in Slovak Alzheimer's disease patients

41/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of integrative neuroscience

Key finding: Four out of 10 TREM2 mutant variants have been identified in the analyzed groups, namely rs75932628 C > T (R47H), rs142232675 C > T (D87N), rs143332484 C > T (R62H), and rs2234253 G > T (T96K). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Plasma p-tau181 associated with structural changes in mild cognitive impairment

52/100 ✓ Peer-reviewed Biomarkers Aging clinical and experimental research

Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with dementia and is a serious concern for the health of individuals and government health care systems worldwide. +4 more findings

• Biomarkers
• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source