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Brain-age is associated with progression to dementia in memory clinic patients
Biondo F, Jewell A, Pritchard M, Aarsland D, Steves CJ, Mueller C, Cole JH.. NeuroImage. Clinical, 2022-08-30
Topic: Risk, prevention and care in population studies
Background Biomarkers for the early detection of dementia risk hold promise for better disease monitoring and targeted interventions. However, most biomarker studies, particularly in neuroimaging, have analysed artificially 'clean' research groups, free from comorbidities, erroneous referrals, contraindications and from a narrow sociodemographic pool. Such biases mean that neuroimaging samples are often unrepresentative of the target population for dementia risk (e.g., people referred to a memory clinic), limiting the generalisation of these studies to real-world clinical settings.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Biondo, F., Jewell, A., Pritchard, M., Aarsland, D., Steves, C. J., Mueller, C., et al. (2022). Brain-age is associated with progression to dementia in memory clinic patients. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2022.103175
Vancouver
Biondo F, Jewell A, Pritchard M, Aarsland D, Steves CJ, Mueller C, et al. Brain-age is associated with progression to dementia in memory clinic patients. NeuroImage. Clinical. 2022. doi:10.1016/j.nicl.2022.103175. PMID: 36087560.
BibTeX
@article{biondo2022-36087560,
author = {Biondo, F. and Jewell, A. and Pritchard, M. and Aarsland, D. and Steves, C. J. and Mueller, C. and Cole, J. H.},
title = {{Brain-age is associated with progression to dementia in memory clinic patients}},
journal = {NeuroImage. Clinical},
year = {2022},
doi = {10.1016/j.nicl.2022.103175},
pmid = {36087560},
url = {https://doi.org/10.1016/j.nicl.2022.103175}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- However, most biomarker studies, particularly in neuroimaging, have analysed artificially 'clean' research groups, free from comorbidities, erroneous referrals, contraindications and from a narrow sociodemographic pool.
- Such biases mean that neuroimaging samples are often unrepresentative of the target population for dementia risk (e.g., people referred to a memory clinic), limiting the generalisation of these studies to real-world clinical settings.
- To facilitate better translation from research to the clinic, datasets that are more representative of dementia patient groups are warranted.
- Methods We analysed T1-weighted MRI scans from a real-world setting of patients referred to UK memory clinic services (n = 1140; 60.2 % female and mean [SD] age of 70.0[10.8] years) to derive 'brain-age'.
Why it matters
This study examined whether a brain-age measure is linked to progression to dementia in memory clinic patients, using a sample meant to be more representative of real clinics. It is about early detection of dementia risk, not about treating, curing or preventing the disease.
Study details
- Participants1,140
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage. Clinical) |
| Journal's citation record | 1 / 4 | NeuroImage Clinical: journal h-index 133 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,140 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 110 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 18.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 12.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 89 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author James Howard Cole: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36087560) |
| Free to read | 2 / 2 | Free to read |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.nicl.2022.103175
- PubMed: 36087560
- Original source →
- Free full text: NeuroImage Clinical →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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