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Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease
Ling-Chun Huang, Ming-Hui Chen, Chih-Pin Chuu, Kuan-Ying Li, Tzyh-Chyuan Hour, Yuan-Han Yang. Frontiers in aging neuroscience, 2022-08-30
Topic: Plasma and spinal-fluid biomarkers
Family history (FH) of late-onset Alzheimer's disease (AD) is associated with changes in several cerebrospinal fluid (CSF) biomarkers in cognitively normal individuals. However, potential changes in plasma biomarkers remain unknown. This study aimed to evaluate potential plasma biomarkers and their correlation in cognitively normal adult children (AC) and to compare this data with their AD parents and unrelated non-demented controls (NC). Participants with dementia due to AD, their AC and NC were recruited. Plasma samples were assessed for amyloid beta (Aβ)1-42, Aβ1-40, total tau (T-tau) and phosphorylated tau (P-tau). Kruskal-Wallis test was used for the comparison of this data between the three groups. Spearman rank correlation was used for evaluation of the correlations between Aβ1-40 and Aβ1-42, and T-tau and P-tau in the AD and AC groups. A total of 99 subjects completed the assessment (30 had AD; 38 were AC group; and 31 were NC). Compared with the NC group, there were significantly higher levels of Aβ1-40, P-tau, and P-tau/T-tau ratio, and lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio in the AD and AC groups. The correlation between the level of Aβ1-42 and Aβ1-40 and level of T-tau and P-tau was only observed in the AC but not in the AD group. AC of AD parents demonstrate some indicators of AD like their parents. Disruption to the correlation between Aβ and tau in AD may be a biomarker for the development of AD in AC, which should be examined in a longitudinal cohort.
Key findings
- Family history (FH) of late-onset Alzheimer's disease (AD) is associated with changes in several cerebrospinal fluid (CSF) biomarkers in cognitively normal individuals.
- Compared with the NC group, there were significantly higher levels of Aβ1-40, P-tau, and P-tau/T-tau ratio, and lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio in the AD and AC groups.
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Study details
- Study designlongitudinal study
- Participants99
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 99 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36110426) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Huang, L.-C., Chen, M.-H., Chuu, C.-P., Li, K.-Y., Hour, T.-C., & Yang, Y.-H. (2022). Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2022.977515
Vancouver
Huang L.-C, Chen M.-H, Chuu C.-P, Li K.-Y, Hour T.-C, Yang Y.-H. Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease. Frontiers in aging neuroscience. 2022. doi:10.3389/fnagi.2022.977515. PMID: 36110426.
BibTeX
@article{huang2022-36110426,
author = {Huang, Ling-Chun and Chen, Ming-Hui and Chuu, Chih-Pin and Li, Kuan-Ying and Hour, Tzyh-Chyuan and Yang, Yuan-Han},
title = {{Plasma biomarkers and their correlation in adult children of parents with Alzheimer's disease}},
journal = {Frontiers in aging neuroscience},
year = {2022},
doi = {10.3389/fnagi.2022.977515},
pmid = {36110426},
url = {https://doi.org/10.3389/fnagi.2022.977515}
}
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