alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,776–9,800 of 27,380 studies, newest first · page 392 of 1096.

September 2021 25

  1. 2021-09-23

    Carotid Arterial Compliance and Aerobic Exercise Training in Chronic Traumatic Brain Injury: A Pilot Study

    ✓ Peer-reviewed Prevention trials The Journal of head trauma rehabilitation

    Key finding: Relative to HC, the participants with cTBI had lower CAC (0.10 ± 0.03 vs 0.12 ± 0.03 mm 2 /mm Hg, P = .046) and higher CVR (0.17 ± 0.03 vs 0.15 ± 0.03 mm Hg/mL/min, P = .028). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-09-23

    CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: CSF synaptic biomarkers increase in the early preclinical stages of the Alzheimer continuum even when a low burden of Aβ pathology is present, and they differ in their association with age, sex, APOE ε4 , and markers of neurodegeneration. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-09-22

    Evaluation of an Interprofessional Academic-Practice Partnership in End of Life Care

    ✓ Peer-reviewed End-of-life care Innovations in pharmacy

    Key finding: Patients in Group 1 were on statistically significant fewer medications than Group 2 at both week 4 and weeks 7-12 following admission. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-09-22

    Retinal Vasculopathy in Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Frontiers in neuroscience

    Key finding: Subsequent studies validated these findings and further identified electroretinography and vision deficits, retinal (p)tau and inflammation, intracellular Aβ accumulation, and retinal ganglion cell-subtype degeneration surrounding Aβ plaques in these patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-09-22

    Detection of Cerebrospinal Fluid Neurofilament Light Chain as a Marker for Alpha-Synucleinopathies

    ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

    Key finding: Interestingly, we observed that CSF-NfL was significantly elevated in patients with DLB and MSA compared to patients with PD or control donors. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2021-09-22

    Mediterranean diet and cognitive function: From methodology to mechanisms of action

    ✓ Peer-reviewed Prevention trials Free radical biology & medicine

    Key finding: Data from multiple randomized clinical trials have demonstrated its powerful effect against oxidative stress, inflammation and the development and progression of cardiovascular disease, type 2 diabetes, and other metabolic conditions that play a crucial role in the pathogenesis of neurodegenerative diseases. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-09-22

    Feasibility and Acceptability of a Web-Based Caregiver Decision Aid (Safety in Dementia) for Firearm Access: Pilot Randomized Controlled Trial

    ✓ Peer-reviewed Treatments JMIR formative research

    Key finding: SiD represents a new resource for promoting safety among people with dementia, and high acceptability was achieved in a pilot trial. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2021-09-21

    The case for low-level BACE1 inhibition for the prevention of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Nature reviews. Neurology

    Key finding: Preventive therapies for AD are not yet available, and potential disease-modifying therapies targeting amyloid-β plaques in symptomatic stages of AD have only just been approved in the United States. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-09-20

    Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives

    ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews

    Key finding: AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ) peptides) and neurofibrillary tangles (formed by hyper-phosphorylated tau protein). +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-09-20

    Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE ɛ4 Carriers

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: Previous research has shown that elevated blood C-reactive protein (CRP) is associated with increased Alzheimer disease (AD) risk only in APOE ε4 allele carriers; the objective of this study was to examine the interactive effects of plasma CRP and APOE genotype on cognition and AD biomarkers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-09-20

    Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at Autopsy

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Elecsys-derived CSF biomarkers detect AD neuropathologic changes with very high discriminative accuracy in vivo. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2021-09-18

    Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study

    ✓ Peer-reviewed Brain scans and imaging Translational psychiatry

    Key finding: Significant cognitive decline was first observed in stage 1 when tau levels only increased in transentorhinal regions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-09-17

    Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

    ✓ Peer-reviewed Disease mechanisms Journal of advanced research

    Key finding: Recent research on the implications of gut microbiota on brain functions has helped to gather important information on the relationship between them. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-09-17

    Can we learn lessons from the FDA's approval of aducanumab?

    ✓ Peer-reviewed Drug development Nature reviews. Neurology

    Key finding: This decision makes aducanumab the first new drug to be approved for the treatment of AD since 2003 and the first drug to ever be approved for modification of the course of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-09-17

    Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study

    ✓ Peer-reviewed Risk factors BMJ (Clinical research ed.)

    Key finding: Of 6 952 440 vaccinated patients in the derivation cohort, 5 150 310 (74.1%) had two vaccine doses. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-09-16

    Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

    ✓ Peer-reviewed Disease mechanisms Pharmacology & therapeutics

    Key finding: Pathologically, gut dysbiosis disrupts the integrity of the intestinal barrier leading to ingress of pathobionts and toxic metabolites into the systemic circulation causing GBA dysregulation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-09-16

    Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals

    ✓ Peer-reviewed Biomarkers Environment international

    Key finding: In a population of cognitively unimpaired adults with increased risk of AD, long-term exposure to air pollution was associated with higher levels in biomarkers of AD pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-09-16

    NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-09-16

    Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Brain sciences

    Key finding: We observed a positive association between the ages of AD and hypothyroidism onset after accounting for APOE-Ɛ4 (correlation: 0.44, 0.24, 0.60; odds ratio: 1.09, 1.05-1.14). +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2021-09-16

    Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study

    ✓ Peer-reviewed Genetics Neurology

    Key finding: These results from the largest longitudinal cohort registry of patients with CAA-ri support the transient and potentially relapsing inflammatory nature of the clinical-radiologic acute manifestations of the disease and the effectiveness of slow oral tapering off after IV corticosteroid pulse therapy in preventing recurrences. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-09-15

    Neuroimaging and biomarker evidence of neurodegeneration in asthma

    ✓ Peer-reviewed Biomarkers The Journal of allergy and clinical immunology

    Key finding: Asthma participants had widespread and large-magnitude differences in several dMRI metrics, which were indicative of neuroinflammation and neurodegeneration, and which were robustly associated with GFAP and, to a lesser extent, NfL. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-09-15

    Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's disease (AD) etiology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-09-15

    Stroke in Africa: profile, progress, prospects and priorities

    ✓ Peer-reviewed Caregiving Nature reviews. Neurology

    Key finding: However, evidence indicates that, today, Africa could have up to 2-3-fold greater rates of stroke incidence and higher stroke prevalence than western Europe and the USA. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-09-15

    Regional age-related atrophy after screening for preclinical alzheimer disease

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: When modeling age with the estimated derivative of smoothed aging curves, we found that the temporal lobe declined linearly with age, subcortical regions declined faster at later ages, and frontal regions declined slower at later ages than during midlife. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2021-09-14

    Caring for Patients With Dementia at End of Life

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Care of the dementia patient continues to be challenging. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →