Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,276–7,300 of 27,380 studies, newest first · page 292 of 1096.
October 2023 25
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2023-10-11
Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline
67/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: This study included patients with clinical SCD and SCD-free, healthy control (HC) participants with available baseline CSF and/or longitudinal cognitive data from the observational DZNE Longitudinal Cognitive Impairment and Dementia study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-10
Post-stroke dysphagia and ambient air pollution are associated with dementia
57/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience
Key finding: The univariable regression models revealed a higher likelihood of dementia diagnosis in patients with dysphagia (odds ratio = 1.493, 95% confidence interval = 1.000-2.228). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-10
Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature
45/100 ✓ Peer-reviewed Treatments Frontiers in aging neuroscience
Key finding: Out of 538 articles, 23 (4.27%) were published in journals from the geriatric category, 44 (8.18%) included an author affiliated with a geriatric institution. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-09
Precision Medicine Approach to Alzheimer's Disease: Rationale and Implications
49/100 ✓ Peer-reviewed Health systems and care delivery Journal of Alzheimer's disease : JAD
Key finding: Here we review the rationale for a precision medicine approach in prevention and treatment of cognitive decline associated with AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-07
Guidelines for pharmacotherapy in Alzheimer's disease - A primer on FDA-approved drugs
41/100 ✓ Peer-reviewed Treatments Journal of neurosciences in rural practice
Key finding: Both act by binding with fibrillary conformations of Aβ plaques in the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-07
Plasma neurofilament light chain associated with impaired regional cerebral blood flow in healthy individuals
59/100 ✓ Peer-reviewed Biomarkers Current journal of neurology
Key finding: We found non-significant differences in age (F(2, 141) = 1.304; P = 0.275) and years of education (F(2, 141) = 0.013; P = 0.987). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-06
The therapeutic landscape of tauopathies: challenges and prospects
41/100 ✓ Peer-reviewed Clinical trials Alzheimer's research & therapy
Key finding: While no effective treatments are currently approved, there is increasing evidence to suggest that various therapeutic approaches may slow the progression of tauopathies or improve symptoms.
Full summary, score breakdown and related studies → Original source
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2023-10-06
Pathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort
73/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Previously reported pathogenic variants in the six genes were identified in 1.35% of EOAD (3/223) and 6.58% of EOnonAD (5/76). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-05
Impact of Microbiome-Brain Communication on Neuroinflammation and Neurodegeneration
41/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences
Key finding: The gut microbiome plays a pivotal role in maintaining human health, with numerous studies demonstrating that alterations in microbial compositions can significantly affect the development and progression of various immune-mediated diseases affecting both the digestive tract and the central nervous system (CNS). +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-10-05
The cell biology of APOE in the brain
43/100 ✓ Peer-reviewed Genetics Trends in cell biology
Key finding: A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets, defects in endolysosomal trafficking, impaired mitochondrial metabolism, upregulation of innate immune pathways, and a transition into a reactive state.
Full summary, score breakdown and related studies → Original source
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2023-10-04
Comprehensive Older Adult and Caregiver Help (COACH): A person-centered caregiver intervention prevents elder mistreatment
82/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: The treatment group had no EM after intervention completion (assessed at 3-month follow-up), a significantly lower rate than the control group (treatment = 0%, control = 23.1%, p = 0.010). +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-04
LATE-NC in Alzheimer's disease: Molecular aspects and synergies
43/100 ✓ Peer-reviewed Brain tissue and pathology Brain pathology (Zurich, Switzerland)
Key finding: Limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) accumulates in the majority of AD cases and leads to more severe cognitive decline compared with AD pathology alone.
Full summary, score breakdown and related studies → Original source
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2023-10-04
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning
50/100 ✓ Peer-reviewed Genetics Genome medicine
Key finding: Five loci showed genome-wide significant association with CSF profiles, two were novel (rs145791381 [inflammation] and GRIN2D [synaptic functioning]) and three were previously described (APOE, TMEM106B, and CHI3L1). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-03
Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype
45/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: Alzheimer's disease, the most common cause of dementia, is a chronic degenerative disease with typical pathological features of extracellular senile plaques and intracellular neurofibrillary tangles and a significant decrease in the density of neuronal dendritic spines. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-03
Clinical considerations in early-onset cerebral amyloid angiopathy
45/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology
Key finding: Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease associated with brain haemorrhage and cognitive change. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-03
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
41/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration
Key finding: The increase in blood flow evoked by whisker stimulation (functional hyperemia) or by endothelial and smooth muscle vasoactivity was markedly attenuated in WT → Tg2576 chimeras but was fully restored in CD36-/- → Tg2576 chimeras, in which BAM ROS production was suppressed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-03
Association of Chronic Pain with Biomarkers of Neurodegeneration, Microglial Activation, and Inflammation in Cerebrospinal Fluid and Impaired Cognitive Function
63/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology
Key finding: Debate surrounds the role of chronic pain as a risk factor for cognitive decline and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-03
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet
65/100 ✓ Peer-reviewed Clinical trials Neurology
Key finding: 272 participants randomized across 43 global sites +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-02
Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
58/100 ✓ Peer-reviewed Inflammation and the immune system Life sciences
Key finding: Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-02
Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update
52/100 ✓ Peer-reviewed Drug development Journal of biomedical science
Key finding: The pathogenesis of AD involves various pathophysiological events, including the accumulation of amyloid and tau, neuro-inflammation, and neuronal injury. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-02
Balance and Gait: Associations With Cognitive Impairment and Dementia in Individuals With Down Syndrome
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer disease and associated disorders
Key finding: Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-02
Metformin Cessation and Dementia Incidence
65/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open
Key finding: In this study, terminating metformin treatment was associated with increased dementia incidence. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-10 month only
Donanemab: Not two without a third
45/100 ✓ Peer-reviewed Treatments Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Key finding: While these antibodies have been shown to significantly reduce amyloid in the brain, there is little, if any, evidence that they provide clinically meaningful benefit for AD patients by slowing cognitive decline.
Full summary, score breakdown and related studies → Original source
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2023-10 month only
Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease
41/100 ✓ Peer-reviewed Risk genes beyond APOE Human gene therapy
Key finding: In this study, we describe the development of a gene therapy vector expressing a wild-type (WT) copy of human PSEN1 to ameliorate the loss of function associated with PSEN1 mutations. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-10-01
Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US
69/100 ✓ Peer-reviewed Risk factors JAMA internal medicine
Key finding: In this cohort study, higher residential PM2.5 levels, especially from agriculture and wildfires, were associated with higher rates of incident dementia, providing further evidence supporting PM2.5 reduction as a population-based approach to promote healthy cognitive aging. +4 more findings
Full summary, score breakdown and related studies → Original source
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