Newest studies

The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease

43/100 ✓ Peer-reviewed Drug development Frontiers in endocrinology

Key finding: Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models. +4 more findings

• Treatments
• Brain Biology

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Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

50/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: An exception was SMOC1, a key member of the brain matrisome module associated with amyloid-β deposition in AD, which was found to be elevated in both CSF and plasma. +1 more finding

• Biomarkers

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Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach

44/100 ✓ Peer-reviewed Digital health tools The EPMA journal

Key finding: In sub-populations such as diabetes mellitus type 2, proliferative diabetic retinopathy is an independent predictor of ischemic stroke. +4 more findings

• Digital Tools

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Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice: A Scoping Review

52/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Temperature extremes and variability both associated with stroke incidence and severity, migraine headaches, hospitalization in patients with dementia, and multiple sclerosis exacerbations. +2 more findings

• Risk Factors

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The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases

40/100 ✓ Peer-reviewed Drug development Molecular neurobiology

Key finding: Compelling evidence suggests that any insult or injury to the CNS, such as traumatic brain injury (TBI), infectious diseases, or neurodegenerative disorders, can provoke an inflammatory response in the CNS.

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

45/100 ✓ Peer-reviewed Genetics Nature

Key finding: Here, to gain more comprehensive insights into the impact of APOE4 on the human brain, we performed single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers. +3 more findings

• Genetics
• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Telemedicine for neurological diseases: A systematic review and meta-analysis

78/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of neurology

Key finding: Well-designed and executed RCTs are needed to confirm our findings on stroke and to have more scientific evidence available for the other neurological diseases. +3 more findings

• Digital Tools

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Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis

64/100 ✓ Peer-reviewed Hippocampus size on brain scans Translational neurodegeneration

Key finding: Our findings reveal that specific gut microbial features are closely associated with cognitive impairment and decreased hippocampal volume, which may play an important role in dementia development. +3 more findings

• Brain Scans

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CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology

54/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: CSF biomarkers β-amyloid 1-42 (Aβ 42 ), phosphorylated tau 181 (p-tau 181 ), total tau (t-tau), and neurogranin (Ng) can diagnose Alzheimer disease (AD) in life. +3 more findings

• Biomarkers

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Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

47/100 ✓ Peer-reviewed TREM2 and immune genetics Scientific reports

Key finding: Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few have examined phagocytosis of normally aged microglia. +3 more findings

• Genetics
• Brain Biology

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Effect of Cholinesterase Inhibitors on Mortality in Patients With Dementia: A Systematic Review of Randomized and Nonrandomized Trials

73/100 ✓ Peer-reviewed Treatments Neurology

Key finding: We included randomized controlled trials (RCTs) and nonrandomized controlled studies at lower risk of bias comparing ChEI treatment with placebo or usual treatment, for 6 months or longer, in patients with dementia of any type. +4 more findings

• Treatments
• Clinical Trials

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Combined Effects of Synaptic and Axonal Integrity on Longitudinal Gray Matter Atrophy in Cognitively Unimpaired Adults

50/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Forty-six clinically normal older adults (mean age = 70 years; 43% female) were included. +1 more finding

• Biomarkers
• Brain Biology
• Early Stage

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Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality: A prospective cohort study

57/100 ✓ Peer-reviewed Long-term cohort studies Journal of sport and health science

Key finding: Whether or not there is targeted pharmacotherapy for dementia, an active and healthy lifestyle that includes physical activity (PA) may be a better option than medication for preventing dementia. +3 more findings

• Risk Factors
• Lifestyle

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Improving generalizability and study design of Alzheimer's disease cohort studies in the United States by including under-represented populations

47/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our successes demonstrate that it is possible to increase the inclusion and engagement of under-represented populations into US-based clinical studies, thereby increasing the generalizability of their results.

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Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease

59/100 ✓ Peer-reviewed Biomarkers npj Parkinson's Disease

Key finding: At baseline, plasma p-tau181 concentration was significantly higher in PD subjects compared with HC ( p = 0.026). +2 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Dementia Care at the End of Life: A Clinically Focused Review

41/100 ✓ Peer-reviewed End-of-life care The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: As dementia is an invariably progressive and terminal illness, planning for and managing end of life care in dementia is an important part of the overall process of dementia care.

• End-of-Life Care

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Differential Gene Expression and DNA Methylation in the Risk of Depression in LOAD Patients

41/100 ✓ Peer-reviewed Genetics Biomolecules

Key finding: Differential expression analysis did not reveal significant association between differences in gene expression and the risk of depression in LOAD. +3 more findings

• Genetics

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Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease

72/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: This fully-automated and available blood-based biomarker assay therefore may be useful for early detection, diagnosis, prognosis, and treatment monitoring of AD. +4 more findings

• Biomarkers
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays

60/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Several plasma p-tau biomarkers can be used in a specialized memory clinic as a stand-alone biomarker to detect biologically-defined AD. +1 more finding

• Biomarkers
• Care Services

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Despite Recommendations, Anticholinergics Account for the Majority of Prescriptions to Treat Overactive Bladder in the United States

36/100 ✓ Peer-reviewed Risk factors Urogynecology

Key finding: From 2013 to 2019, Medicare Part D beneficiaries 65 years or older received 47.7 million 30-day fills for the treatment of OAB. +4 more findings

• Side Effects

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Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment

40/100 ✓ Peer-reviewed Drug development Pharmacological research

Key finding: Interestingly, increased inflammation and neurodegenerative disease risk have been associated with type 2 diabetes mellitus (T2DM) and insulin resistance (IR), suggesting that treatments that mitigate T2DM pathology may be successful in treating neuroinflammatory and neurodegenerative pathology as well. +1 more finding

• Treatments
• Brain Biology
• Policy

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Re: Aducanumab-Related ARIA: Paean or Lament?

32/100 ✓ Peer-reviewed Drug development Clinical nuclear medicine

Key finding: Høilund-Carlsen and colleagues raise concern regarding the reliability of amyloid PET to exclude Alzheimer disease. +1 more finding

• Treatments

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The effectiveness of non-pharmacological interventions using information and communication technologies for behavioral and psychological symptoms of dementia: A systematic review and meta-analysis

56/100 ✓ Peer-reviewed Digital health tools International journal of nursing studies

Key finding: A meta-analysis using a random-effects model was performed to calculate the pooled standardized mean differences between overall symptoms and each type of symptom. +3 more findings

• Digital Tools

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A Psychosocial Intervention for Supporting Informal Caregivers of Older People With Alzheimer Disease: Protocol for the InnFamiglia Randomized Controlled Trial

47/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: We hypothesize that the experimental group will be more effective in managing caregiver burden and coping strategies and that this will improve the perception of well-being, anxiety, and depression among caregivers. +3 more findings

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases

41/100 ✓ Peer-reviewed Disease mechanisms Journal of neurology

Key finding: We discuss two primary hypotheses that suggest that either α-synuclein aggregation occurs in the gut and spreads in a prion-like fashion to the brain or systemic inflammatory processes driven by gastrointestinal dysfunction contribute to the pathophysiology of Lewy body diseases.

• Other Dementias

Full summary, score breakdown and related studies → Original source