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Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease
Arranz J, Zhu N, Rubio-Guerra S, Rodríguez-Baz í, Carmona-Iragui M, Barroeta I, Illán-Gala I, Santos-Santos M et al.. medRxiv, 2023-04-26
Topic: Amyloid, tau and blood-test diagnosis
BACKGROUND Recently-developed blood markers for Alzheimer’s (AD) detection have high accuracy but usually require ultra-sensitive analytic tools not commonly available in clinical laboratories. METHODS We analyzed plasma samples from 367 consecutive participants in the SPIN cohort, comprising 302 euploid participants (67 cognitively unimpaired, 136 participants with mild cognitive impairment, and 99 with dementia) and 65 with Down Syndrome (46 non-demented and 19 with AD dementia). Participants were classified according to CSF biomarkers status using the AT(N) system.
Key findings
- METHODS We analyzed plasma samples from 367 consecutive participants in the SPIN cohort, comprising 302 euploid participants (67 cognitively unimpaired, 136 participants with mild cognitive impairment, and 99 with dementia) and 65 with Down Syndrome (46 non-demented and 19 with AD dementia).
- Participants were classified according to CSF biomarkers status using the AT(N) system.
- Plasma Aβ 1–42 , Aβ 1–40 and pTau 181 were measured in the fully-automated LUMIPULSE platform.
- We used ANOVA to compare plasma biomarkers concentrations between AT(N) groups, evaluated Spearman’s correlation between plasma and CSF and performed ROC analyses to assess their diagnostic accuracy to detect AD.
Why it matters
This study tested blood markers for Alzheimer's disease on an automated lab platform in 367 people, including some with Down syndrome. It shows these blood tests can be run on standard equipment, but the text does not report how well they performed or any treatment implications.
Study details
- Participants136
- Effect sizeAUC=0.94
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 31 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 29 of the 94 points we could judge it on, which is 31 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 136 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Daniel Andres Alcolea: h-index 66 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Universitat Autònoma de Barcelona: institution h-index 782 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 29 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 29 of the 94 points we could judge it on is 31 out of 100. |
| Total | 31 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Arranz, J., Zhu, N., Rubio-Guerra, S., í, R.-B., Carmona-Iragui, M., Barroeta, I., et al. (2023). Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease. medRxiv. https://doi.org/10.1101/2023.04.20.23288852
Vancouver
Arranz J, Zhu N, Rubio-Guerra S, í R.-B, Carmona-Iragui M, Barroeta I, et al. Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease. medRxiv. 2023. doi:10.1101/2023.04.20.23288852.
BibTeX
@article{arranz2023-d99e2e19,
author = {Arranz, J. and Zhu, N. and Rubio-Guerra, S. and í, Rodríguez-Baz and Carmona-Iragui, M. and Barroeta, I. and Illán-Gala, I. and Santos-Santos, M. and others},
title = {{Diagnostic performance of plasma Aβ 1-42 , Aβ 1-40 and pTau 181 in the LUMIPULSE automated platform for the detection of Alzheimer disease}},
journal = {medRxiv},
year = {2023},
doi = {10.1101/2023.04.20.23288852},
url = {https://doi.org/10.1101/2023.04.20.23288852}
}
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