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64/100

✓ Peer-reviewed alzhub usefulness score 64 out of 100. Biomarkers

Topic: Plasma and spinal-fluid biomarkers

Pathophysiological substrate(s) and progression of Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) are still matter of debate. Baseline cerebrospinal fluid (CSF) neurochemical profile and cognitive changes after 2 years were investigated in a retrospective series of PD-MCI (n = 48), cognitively normal PD (PD-CN, n = 40), prodromal Alzheimer's disease (MCI-AD, n = 25) and cognitively healthy individuals with other neurological diseases (OND, n = 44). CSF biomarkers reflecting amyloidosis (Aβ42/40 ratio, sAPPα, sAPPβ), tauopathy (p-tau), neurodegeneration (t-tau, NfL, p-NfH), synaptic damage (α-syn, neurogranin) and glial activation (sTREM2, YKL-40) were measured. The great majority (88%) of PD-MCI patients was A-/T-/N-. Among all biomarkers considered, only NfL/p-NfH ratio was significantly higher in PD-MCI vs. PD-CN (p = 0.02). After 2 years, one-third of PD-MCI patients worsened; such worsening was associated with higher baseline levels of NfL, p-tau, and sTREM2. PD-MCI is a heterogeneous entity requiring further investigations on larger, longitudinal cohorts with neuropathological verification.

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APA 7th

Paoletti, F. P., Gaetani, L., Bellomo, G., Chipi, E., Salvadori, N., Montanucci, C., et al. (2023). CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment. NPJ Parkinson's disease. https://doi.org/10.1038/s41531-023-00509-w

Vancouver

Paoletti FP, Gaetani L, Bellomo G, Chipi E, Salvadori N, Montanucci C, et al. CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment. NPJ Parkinson's disease. 2023. doi:10.1038/s41531-023-00509-w. PMID: 37095141.

BibTeX

@article{paoletti2023-37095141,
  author  = {Paoletti, Federico Paolini and Gaetani, Lorenzo and Bellomo, Giovanni and Chipi, Elena and Salvadori, Nicola and Montanucci, Chiara and Mancini, Andrea and Filidei, Marta and others},
  title   = {{CSF neurochemical profile and cognitive changes in Parkinson's disease with mild cognitive impairment}},
  journal = {NPJ Parkinson's disease},
  year    = {2023},
  doi     = {10.1038/s41531-023-00509-w},
  pmid    = {37095141},
  url     = {https://doi.org/10.1038/s41531-023-00509-w}
}

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Key findings

Among all biomarkers considered, only NfL/p-NfH ratio was significantly higher in PD-MCI vs.
After 2 years, one-third of PD-MCI patients worsened; such worsening was associated with higher baseline levels of NfL, p-tau, and sTREM2.

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Study details

Study designlongitudinal study
Participants48
Evidence strengthModerate

How this study scored 64/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (NPJ Parkinson's disease)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	1 / 4	48 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37095141)
Free to read	— / 2	Access not recorded — left out of this score
Points	36 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100.
Total	64 / 100	—

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