Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,226–20,250 of 27,380 studies, newest first · page 810 of 1096.
March 2011 25
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2011-03-15
Geographic Variation in Diagnosis Frequency and Risk of Death Among Medicare Beneficiaries
53/100 ✓ Peer-reviewed Risk factors JAMA
Key finding: Diagnosis frequency ranged across HRRs from 0.58 chronic conditions in Grand Junction, Colorado, to 1.23 in Miami, Florida (mean, 0.90 [95% confidence interval {CI}, 0.89-0.91]; median, 0.87 [interquartile range, 0.80-0.96]). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-15
Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation
53/100 ✓ Peer-reviewed Risk factors Journal of cardiovascular electrophysiology
Key finding: AF ablation patients were less likely to have diabetes, but were more likely to have hypertension, HF, and significant valvular heart disease. +4 more findings
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2011-03-15
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
64/100 ✓ Peer-reviewed Genetics Molecular psychiatry
Key finding: We obtained significant association (P(adj)<0.03; odds ratio (OR)=1.24 (95% confidence interval (CI): 1.02-1.51)) for one CR1 risk haplotype, and haplotype association was strongest in individuals carrying apolipoprotein E (APOE) ɛ4 alleles (P(adj)<0.006; OR=1.50 (95% CI: 1.08-2.09)). +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-14
Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology
Key finding: Dynamic [(11)C]PiB PET can be used successfully to measure cerebral β-amyloid deposition in DS. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-14
Prevalence of stroke and related burden among older people living in Latin America, India and China
58/100 ✓ Peer-reviewed Disparities Journal of neurology, neurosurgery, and psychiatry
Key finding: The prevalence of stroke in urban LA and Chinese sites is nearly as high as in industrialised countries.
Full summary, score breakdown and related studies → Original source
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2011-03-11
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
60/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology
Key finding: There is a clear need to develop biomarkers for Parkinson disease (PD) diagnosis, differential diagnosis of Parkinsonian disorders, and monitoring disease progression. +3 more findings
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2011-03-09
CR1 is associated with amyloid plaque burden and age-related cognitive decline
66/100 ✓ Peer-reviewed Genetics Annals of neurology
Key finding: We found that common variation at the CR1 locus has a broad impact on cognition and that this effect is largely mediated by an individual's amyloid plaque burden. +3 more findings
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2011-03-09
Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein
35/100 ✓ Peer-reviewed Tau biomarkers Journal of neural transmission (Vienna, Austria : 1996)
Key finding: Six Tau isoforms are expressed in adult human brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-08
Prevalence of dementia and cognitive impairment among older adults with hip fractures
67/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association
Key finding: We conclude that dementia and cognitive impairment are common among older adults with hip fractures. +3 more findings
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2011-03-08
All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study
69/100 ✓ Peer-reviewed How common it is BMJ (Clinical research ed.)
Key finding: Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-03-07
Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging
36/100 ✓ Peer-reviewed Brain scans and imaging Cerebral cortex (New York, N.Y. : 1991)
Key finding: Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). +4 more findings
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2011-03-03
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Consistent with the emerging concept of prion-like transmissibility of disease-causing amyloidogenic proteins, we found that spontaneous uptake of Tau pffs into cells is likely mediated by endocytosis, suggesting a potential mechanism for the propagation of Tau lesions in tauopathy brains.
Full summary, score breakdown and related studies → Original source
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2011-03-01
Deaths: preliminary data for 2009
36/100 ✓ Peer-reviewed Disparities National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
Key finding: The age-adjusted death rate decreased from 758.7 deaths per 100,000 population in 2008 to 741.0 deaths per 100,000 population in 2009. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-03-01
2011 Alzheimer's disease facts and figures
55/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Dramatic increases in the numbers of "oldest-old" (those aged ≥85 years) across all racial and ethnic groups will also significantly affect the numbers of people living with AD.
Full summary, score breakdown and related studies → Original source
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2011-03-01
Dendritic spine pathology in neuropsychiatric disorders
40/100 ✓ Peer-reviewed Brain tissue and pathology Nature neuroscience
Key finding: Substantial progress has been made toward understanding the genetic architecture, cellular substrates, brain circuits and endophenotypic profiles of neuropsychiatric disorders, including autism spectrum disorders (ASD), schizophrenia and Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
The targets of curcumin
36/100 ✓ Peer-reviewed Treatments Current drug targets
Key finding: In recent years, extensive in vitro and in vivo studies suggested curcumin has anticancer, antiviral, antiarthritic, anti-amyloid, antioxidant, and anti-inflammatory properties. +4 more findings
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2011-03-01
Engaging neuroscience to advance translational research in brain barrier biology
36/100 ✓ Peer-reviewed Tau biomarkers Nature reviews. Neuroscience
Key finding: The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-03-01
Amyloid β-induced death in neurons involves glial and neuronal hemichannels
36/100 ✓ Peer-reviewed Biomarkers The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We report that low concentrations of Aβ(25-35) increased hemichannel activity in all three cell types and microglia initiate these effects triggered by Aβ. +4 more findings
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2011-03-01
Atrial fibrillation and incidence of dementia: a systematic review and meta-analysis
84/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: There is consistent evidence supporting an association between AF and increased incidence of dementia in patients with stroke whereas there remains considerable uncertainty about any link in the broader population. +4 more findings
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2011-03-01
Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study
62/100 ✓ Peer-reviewed Hippocampus size on brain scans The British journal of psychiatry : the journal of mental science
Key finding: Complaints of poor memory by older people, particularly when new, may be a realistic subjective appraisal of recent brain changes independent of observed cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-03-01
Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus
Key finding: Chronic restraint stress (CRS) induces the remodeling (i.e., retraction and simplification) of the apical dendrites of hippocampal CA3 pyramidal neurons in rats, suggesting that intrahippocampal connectivity can be affected by a prolonged stressful challenge. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program
43/100 ✓ Peer-reviewed Prevention trials The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: CT may be a viable secondary prevention technique for late-life depression, a group who are at risk of further cognitive decline and progression to dementia.
Full summary, score breakdown and related studies → Original source
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2011-03-01
Longitudinal deficits to attention, executive, and working memory in subtypes of mild cognitive impairment
49/100 ✓ Peer-reviewed Mild cognitive impairment Neuropsychology
Key finding: The results indicate that a-MCI and na-MCI display a stable pattern of deficits to attention, working memory, and executive function. +2 more findings
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2011-03-01
High blood pressure accelerates gait slowing in well-functioning older adults over 18-years of follow-up
63/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: High BP accelerates gait slowing in well-functioning older adults over a long period of time, even for those who control their BP or develop hypertension later in life. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-03-01
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
49/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: The sirtuin pathway, which is most notable for its association with the anti-ageing effects of calorie restriction, has received particular attention, and pharmacological or transgenic upregulation of the sirtuin pathway has shown promising results in laboratory models of ageing. +1 more finding
Full summary, score breakdown and related studies → Original source
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