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Fusing the Virtual and Physical Worlds to Identify Declines in Instrumental Activities of Daily Living Associated with Parkinson’s Disease (S37.008)
Morgan McGrath, Anson B. Rosenfeldt, Colin Waltz, Mandy Miller Koop, Hubert H. Fernandez, Jay L. Alberts. Neurology, 2023-04-25
Topic: Risk, prevention and care in population studies
Motor and cognitive performance differed across PD and control groups. From a motor perspective, PD patients exhibited significantly shorter step length ( p <0.05) and experienced multiple freezing episodes while turning. Cognitive function was evaluated through list observation behaviors; PD patients spent significantly more time looking at their virtual shopping list ( p <0.01) and time for each list activation was nearly twice that of controls ( p <0.01). Both groups tolerated the virtual environment well, as Simulator Sickness Questionnaire scores for both groups were minimal following completion of CC-VRS. The CC-VRS platform successfully quantifies PD motor symptoms and subtle cognitive declines in mild PD versus healthy controls. The CC-VRS platform was well-tolerated across groups and offers an innovative approach to objectively quantifying IADL performance, with potential for use in titrating medication and tuning deep brain stimulation parameters. Disclosure: Morgan McGrath has nothing to disclose. Anson Rosenfeldt has received personal compensation for serving as an employee of Cleveland Clinic. Anson Rosenfeldt has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Enspire DBS. The institution of Anson Rosenfeldt has received research support from Michael J. The institution of Anson Rosenfeldt has received research support from National Institute of Health. The institution of Anson Rosenfeldt has received research support from Department of Defense. Anson Rosenfeldt has received intellectual property interests from a discovery or technology relating to health care. Fernandez has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Fernandez has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevel. Fernandez has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Fernandez has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Fernandez has received research support from Biogen. Fernandez has received research support from Michael J Fox Founda. Fernandez has received research support from Roche. Fernandez has received research support from Parkinson Foundation. Fernandez has received research support from UCB. Fernandez has received publishing royalties from a pu
Key findings
- Motor and cognitive performance differed across PD and control groups.
- From a motor perspective, PD patients exhibited significantly shorter step length ( p <0.05) and experienced multiple freezing episodes while turning.
- Cognitive function was evaluated through list observation behaviors; PD patients spent significantly more time looking at their virtual shopping list ( p <0.01) and time for each list activation was nearly twice that of controls ( p <0.01).
- Both groups tolerated the virtual environment well, as Simulator Sickness Questionnaire scores for both groups were minimal following completion of CC-VRS.
- The CC-VRS platform successfully quantifies PD motor symptoms and subtle cognitive declines in mild PD versus healthy controls.
Why it matters
A virtual reality platform detected differences in motor and cognitive performance, including more time looking at a shopping list, between people with mild Parkinson's disease and controls. This concerns Parkinson's disease and does not report any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 31/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jay L. Alberts: h-index 43 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Cleveland Clinic: institution h-index 1,139 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 31 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
McGrath, M., Rosenfeldt, A. B., Waltz, C., Koop, M. M., Fernandez, H. H., & Alberts, J. L. (2023). Fusing the Virtual and Physical Worlds to Identify Declines in Instrumental Activities of Daily Living Associated with Parkinson’s Disease (S37.008). Neurology. https://doi.org/10.1212/wnl.0000000000203051
Vancouver
McGrath M, Rosenfeldt AB, Waltz C, Koop MM, Fernandez HH, Alberts JL. Fusing the Virtual and Physical Worlds to Identify Declines in Instrumental Activities of Daily Living Associated with Parkinson’s Disease (S37.008). Neurology. 2023. doi:10.1212/wnl.0000000000203051.
BibTeX
@article{mcgrath2023-687174b6,
author = {McGrath, Morgan and Rosenfeldt, Anson B. and Waltz, Colin and Koop, Mandy Miller and Fernandez, Hubert H. and Alberts, Jay L.},
title = {{Fusing the Virtual and Physical Worlds to Identify Declines in Instrumental Activities of Daily Living Associated with Parkinson’s Disease (S37.008)}},
journal = {Neurology},
year = {2023},
doi = {10.1212/wnl.0000000000203051},
url = {https://doi.org/10.1212/wnl.0000000000203051}
}
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