Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 8,351–8,375 of 27,380 studies, newest first · page 335 of 1096.
October 2022 25
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2022-10-28
Microbiome in Anxiety and Other Psychiatric Disorders
41/100 ✓ Peer-reviewed Disease mechanisms The Medical clinics of North America
Key finding: Initial studies suggested that the fluctuations in the quantity, variety, and composition of the gut microbiota can significantly affect disease processes.
Full summary, score breakdown and related studies → Original source
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2022-10-28
Dysfunctional microglia and tau pathology in Alzheimer's disease
41/100 ✓ Peer-reviewed Inflammation and the immune system Reviews in the neurosciences
Key finding: Abnormalities in tau, Aβ, and microglial activation are frequently observed in dementia patients and indicate that these elements may work in concert to cause cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-10-28
Semiquantitative Approach to Amyloid Positron Emission Tomography Interpretation in Clinical Practice
46/100 ✓ Peer-reviewed Brain scans and imaging World journal of nuclear medicine
Key finding: Visual assessment and semiquantitative analysis provide highly congruent results, thereby enhancing reader confidence and improving scan interpretation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-28
Leveraging mHealth and Virtual Reality to Improve Cognition for Alzheimer's Patients: A Systematic Review
31/100 ✓ Peer-reviewed Health systems and care delivery Healthcare (Basel, Switzerland)
Key finding: Only three interventions reported either no improvements or no statistically significant improvements.
Full summary, score breakdown and related studies → Original source
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2022-10-28
The Hong Kong Grocery Shopping Dialog Task (HK-GSDT): A Quick Screening Test for Neurocognitive Disorders
42/100 ✓ Peer-reviewed Risk factors International journal of environmental research and public health
Key finding: The results showed good reliability (i.e., internal consistency) and structural validity in the HK-GSDT. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-10-27
Microglia and Alzheimer's Disease
41/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences
Key finding: It is imperative to comprehend the intricate mechanisms that result in microglial impairment to develop new immunomodulating therapies that primarily attempt to recover the physiological role of microglia, allowing them to carry out their core function of brain protection.
Full summary, score breakdown and related studies → Original source
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2022-10-27
Effectiveness of Computerized Cognitive Training in Delaying Cognitive Function Decline in People With Mild Cognitive Impairment: Systematic Review and Meta-analysis
81/100 ✓ Peer-reviewed Prevention trials Journal of medical Internet research
Key finding: This systematic review suggests that CCT interventions could improve global cognitive function in patients with MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-26
Air Pollution and Incidence of Dementia: A Systematic Review and Meta-analysis
84/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: A total of 20 studies were included in the systematic review, and 17 provided data for the meta-analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-26
Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer's Drugs
41/100 ✓ Peer-reviewed Treatments Pharmaceutics
Key finding: As a result, the pharmacological therapeutic effectiveness is raised, while the unwanted side effects induced by the unspecific distribution decrease.
Full summary, score breakdown and related studies → Original source
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2022-10-26
Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease
58/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology
Key finding: ALPS-index may provide useful disease progression or treatment biomarkers for patients with AD as an indicator of modulation of glymphatic activity.
Full summary, score breakdown and related studies → Original source
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2022-10-25
The use of psychological network analysis in informal dementia care: an empirical illustration
41/100 ✓ Peer-reviewed Caregiving Aging & mental health
Key finding: The analysis suggests a complex network of interacting variables. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-25
198 A UNIQUE COMMUNITY POST-DIAGNOSTIC DEMENTIA SUPPORT SERVICE DELIVERED BY THE ADVANCED NURSE PRACTITIONER
35/100 ✓ Peer-reviewed Risk factors Age and Ageing
Key finding: Patient satisfaction outcomes range from 71 - 100% with service intervention outcomes favourably indicating the direct impact of the service, which are unmeasurable to the older adult living with dementia, and include increases in: (i) Confidence - 90%; (ii) Mood - 50% and (iii) open to talking through difficulties encountered - 87%. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-25
Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies
56/100 ✓ Peer-reviewed Lewy body dementia International journal of molecular sciences
Key finding: Tauopathies, including Pick's disease, frontotemporal dementia, corticobasal degeneration, Alzheimer's disease, argyrophilic grain disease, progressive supranuclear palsy, and Huntington's disease, are the result of misprocessing and accumulation of tau within the neuronal and glial cells.
Full summary, score breakdown and related studies → Original source
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2022-10-24
Beneficial effects of natural flavonoids on neuroinflammation
41/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in immunology
Key finding: Flavonoids, as a species of important natural compounds, have been widely revealed to alleviate neuroinflammation by inhibiting the production of pro-inflammatory mediators, elevating the secretion of anti-inflammatory factors, and modulating the polarization of microglia and astrocyte, mainly via suppressing the activation of NLRP3 inflammasome, as well as NF-κB, MAPK, and JAK/STAT pathways, promoting Nrf2, AMPK, BDNF/CREB, Wnt/β-Catenin, PI3k/Akt signals and SIRT1-mediated HMGB1 deacetylation.
Full summary, score breakdown and related studies → Original source
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2022-10-24
New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier
43/100 ✓ Peer-reviewed Costs and economics Frontiers in molecular neuroscience
Key finding: Neurological degeneration after neuroinflammation, such as that resulting from Alzheimer's disease (AD), stroke, multiple sclerosis (MS), and post-traumatic brain injury (TBI), is typically associated with high mortality and morbidity and with permanent cognitive dysfunction, which places a heavy economic burden on families and society.
Full summary, score breakdown and related studies → Original source
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2022-10-24
Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses
43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in pharmacology
Key finding: Mounting evidence supports the significant role of Lactobacillus spp. and their components (such as metabolites, peptidoglycans, and/or surface proteins) in modulatingimmune responses, primarily through exchange of immunological signals between gastrointestinal tract and distant organs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-23
Sense of meaning and purpose in life and risk of incident dementia: New data and meta-analysis
66/100 ✓ Peer-reviewed Long-term cohort studies Archives of gerontology and geriatrics
Key finding: A greater sense of meaning and purpose in life is associated with lower dementia risk. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-22
Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration
40/100 ✓ Peer-reviewed Digital health tools Trends in neurosciences
Key finding: Priming by IFN-γ results in proliferation (microgliosis), enhanced synapse elimination, and moderate nitric oxide release sufficient to impair synaptic transmission, gamma rhythm activity, and cognitive functions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-10-21
Genetically identical twins show comparable tau PET load and spatial distribution
54/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely associated with cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-21
APOE4 derived from astrocytes leads to blood-brain barrier impairment
61/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology
Key finding: We found that humanized APOE4, but not APOE2 or APOE3, mice show a leaky blood-brain barrier, increased MMP9, impaired tight junctions, and reduced astrocyte end-foot coverage of blood vessels.
Full summary, score breakdown and related studies → Original source
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2022-10-21
Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults
50/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Multivariable-adjusted regression models, correcting for multiple-testing revealed that, overall, higher NfLv1 was associated with greater global TR (β ± SE: +0.0000560 ± 0.0000186, b = 0.27, p = 0.003, q = 0.012), left frontal WM TR (β ± SE: + 0.0000706 ± 0.0000201, b ± 0.30, p = 0.001, q = 0.0093) and right frontal WM TR (β ± SE: + 0.0000767 ± 0.000021, b ± 0.31, p < 0.001, q = 0.0093). +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-10-21
Vascular Considerations for Amyloid Immunotherapy
40/100 ✓ Peer-reviewed Treatments Current neurology and neuroscience reports
Key finding: Decades of research into anti-Aβ immunotherapies provide evidence for increased Aβ clearance from the brain; however, this is frequently accompanied by complicated vascular deficits. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-21
Interdisciplinary Aging Research to Address Health Disparities in Alzheimer’s Disease and Related Dementias: A Scientific Training Program for Early-Career Scholars
49/100 ✓ Peer-reviewed Health systems and care delivery The Journals of Gerontology Series B
Key finding: According to the National Institute on Aging (NIA), there are more than 70 associated genes or genetic areas associated with Alzheimer’s when 20 years ago, we knew of only four (Hodes, 2022). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-10-20
Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants
43/100 ✓ Peer-reviewed Risk factors Molecules
Key finding: The results obtained suggest that these essential oils may be used to control mosquito vectors that transmit pathogenic viruses or to support the treatment of Alzheimer’s disease.
Full summary, score breakdown and related studies → Original source
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2022-10-20
Development and clinical validation of CT-based regional modified Centiloid method for amyloid PET
52/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: Both MRI-based and CT-based rdcCL scales showed that FMM and FBB were highly correlated with each other, globally and regionally (R2 = 0.96~0.99). +4 more findings
Full summary, score breakdown and related studies → Original source
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