Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,751–7,775 of 27,380 studies, newest first · page 311 of 1096.
April 2023 25
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2023-04-20
Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control
41/100 ✓ Peer-reviewed Disease mechanisms Reviews in the neurosciences
Key finding: As a result, researchers are exploring novel therapeutic modalities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-04-20
Plasma ATN(I) classification and precision pharmacology in Alzheimer's disease
45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Evaluating potential therapies for Alzheimer's disease (AD) depends on use of biomarkers for appropriate subject selection and monitoring disease progression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-20
Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale
47/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: These results will inform the benefit of statins for increasing survival free of dementia and disability among older adults.
Full summary, score breakdown and related studies → Original source
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2023-04-20
Relationships between hourly cognitive variability and risk of Alzheimer's disease revealed with mixed-effects location scale models
41/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychology
Key finding: Preclinical AD risk, defined as possessing at least one APOE ε4 allele, is not only associated with mean-level performance differences, but also with increases in variability across repeated testing occasions particularly on a test of processing speed. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-20
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease
52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma and CSF p-tau 217 had equivalent diagnostic performance for biomarker-defined AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-04-20
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
55/100 ✓ Peer-reviewed TREM2 and immune genetics Nature immunology
Key finding: Here, we sought to identify cues that alter NK cell activity in tumors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-19
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice
41/100 ✓ Peer-reviewed Treatments Toxicology mechanisms and methods
Key finding: Commonly used drugs could ameliorate the intoxication and overall medical outcomes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-19
An anti-amyloid therapy works for Alzheimer's disease: why has it taken so long and what is next?
45/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology
Key finding: They argue that the results mark a turning point for the Alzheimer’s field, but that taking anti-amyloid therapies into clinical practice will be challenging.
Full summary, score breakdown and related studies → Original source
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2023-04-19
Large-Scale Integration of Single-Cell RNA-Seq Data Reveals Astrocyte Diversity and Transcriptomic Modules across Six Central Nervous System Disorders
41/100 ✓ Peer-reviewed Genetics Biomolecules
Key finding: We found that astrocyte subtypes are regionally heterogeneous.
Full summary, score breakdown and related studies → Original source
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2023-04-19
The structural and social determinants of Alzheimer's disease related dementias
57/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Under Bronfenbrenner's macrosystem framework, we highlight key quantitative and qualitative studies linking S/SDOH with AD/ADRD, identify scientific gaps in the literature, and propose guidance for future research.
Full summary, score breakdown and related studies → Original source
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2023-04-18
Measures of cognitive reserve: An umbrella review
71/100 ✓ Peer-reviewed Risk factors The Clinical neuropsychologist
Key finding: Thirty-one reviews were identified, sixteen of which were systematic reviews, and fifteen were meta-analyses. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-18
Optical coherence tomography angiography in neuro-ophthalmology
41/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in ophthalmology
Key finding: Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-18
MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease
47/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Brain cell-derived small extracellular vesicles (sEVs) in blood offer unique cellular and molecular information related to the onset and progression of Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2023-04-17
Brain iron content in cerebral amyloid angiopathy using quantitative susceptibility mapping
48/100 ✓ Peer-reviewed Vascular contributions Frontiers in neuroscience
Key finding: No differences were found between regions of interest in CAA compared to NC. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-17
Correlations between Cognitive Evaluation and Metabolic Syndrome
50/100 ✓ Peer-reviewed Risk factors Metabolites
Key finding: We found that MMSE and MoCA scores were associated with anthropometric parameters, and MoCA was associated with glycemic control parameters and leptin levels.
Full summary, score breakdown and related studies → Original source
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2023-04-17
Lecanemab for Alzheimer's Disease: Effectiveness and Value — Final Evidence Report
16/100 ⚠ Report — not peer-reviewed Costs and economics ICER (independent health technology assessment report)
Key finding: Health-benefit price benchmark calculated at $8,900-$21,500 per year +3 more findings
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2023-04-15
Anti-Amyloid Monoclonal Antibodies are Transformative Treatments that Redefine Alzheimer's Disease Therapeutics
43/100 ✓ Peer-reviewed Treatments Drugs
Key finding: The results of trials of anti-amyloid MABs support the amyloid hypothesis and amyloid as a target for AD drug development.
Full summary, score breakdown and related studies → Original source
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2023-04-15
Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies
48/100 ✓ Peer-reviewed TREM2 and immune genetics Biology
Key finding: We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-04-14
Sensory impairment and algorithmic classification of early cognitive impairment
55/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Cross-sectionally, participants with ≥3 SI had twice the prevalence of ECI (prevalence ratio = 2.10, p = 0.02). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-14
Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia
68/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: A significant difference was observed in plasma Aβ42/Aβ40 ratio between low and high PVS burden, controlling for age (F[1, 53] = 5.59, p = 0.022, η2 = 0.10), with lower Aβ42/Aβ40 ratio in the high PVS burden group. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-04-14
Chronic Pain Among Adults - United States, 2019-2021
16/100 ⚠ Report — not peer-reviewed Risk factors MMWR. Morbidity and mortality weekly report
Key finding: Population research objectives in the National Pain Strategy, which was released in 2016 by the Interagency Pain Research Coordinating Committee, call for more precise estimates of the prevalence of chronic pain and high-impact chronic pain (i.e., chronic pain that results in substantial restriction to daily activities) in the general population and within various population groups to guide efforts to reduce the impact of chronic pain (3).
Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2023-04-14
Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort
16/100 ⚠ Retracted — do not rely on it Long-term cohort studies The Lancet. Public health
Key finding: Dementia and hearing loss are both highly prevalent conditions among older adults. +3 more findings
Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2023-04-13
Blood β-synuclein is related to amyloid PET positivity in memory clinic patients
59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma β-synuclein demonstrated discriminative properties for Aβ PET positive and negative subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-12
A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status
70/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Bisecting N-acetylglucosamine correlated with tau levels (p < 0.0001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-04-12
Effectiveness of computer-based interventions for community-dwelling people with cognitive decline: a systematic review with meta-analyses
56/100 ✓ Peer-reviewed Digital health tools BMC geriatrics
Key finding: The results demonstrated that CCIs have beneficial effects on domain-specific cognition in people with MCI but no significant effects on people with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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