Newest studies

Geographic variation of prevalence of Alzheimer’s Disease and related dementias in the Central Appalachian region of the United States

32/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: As rural areas have lower reported ADRD prevalence compared to urban areas in spite of lower educational attainment (which should lead to higher ADRD prevalence) this argues that the true burden of ADRD is likely underestimated in areas without adequate detection resources. +4 more findings

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Depression is associated with dementia and accelerated cognitive decline in African Americans

33/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Modifiable risk factors associated with dementia were common in AA and NHW participants. +4 more findings

• Health Equity
• Risk Factors

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Associations between structural/social determinants of health and vulnerability for and resilience against Alzheimer’s disease and related dementias: The Healthy Brain Initiative

37/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: S/SDOH can significantly impact health throughout the life course by determining access to health promoting resources and opportunities, which in turn impacts modifiable risk factors (e.g., diet, physical activity, social contact) known to influence Alzheimer’s disease and related dementia (ADRD) risk. +4 more findings

• Lifestyle
• Health Equity

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INDIVIDUAL AND COUNTY-LEVEL FACTORS OF SERVICE USE BY DEMENTIA FAMILY CAREGIVERS IN RURAL APPALACHIA

32/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: These findings suggest that caregivers living in rural regions may depend more on informal support for meeting basic care needs of their relative living with dementia. +2 more findings

• Caregiving
• Health Equity

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The association between the area deprivation index and dementia in a Veteran Population

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: We found a dose‐dependent association between ADI and dementia The ADI may be a valuable tool for identifying high‐risk communities for dementia intervention. +4 more findings

• Risk Factors

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Neighborhood problems and sleep difficulties predict subjective cognitive decline in Black American men living in urban areas

33/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Given that Black Americans have been found to have a higher prevalence of sleep disturbances compared to white Americans, our findings could add to inform future health interventions and policy recommendations that can address modifiable sources of poorer brain health in Black men. +4 more findings

• Early Stage
• Lifestyle

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The influence of Area Deprivation Index on cognition in cognitively‐normal adults as measured by Principal Component Analysis of Neuropsychological Data

40/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Our results suggest that the relationship between greater neighborhood disadvantage and poorer cognitive function are very subtle and may only be present for some, but not all, cognitive domains. +4 more findings

• Health Equity

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Introduction to Special Issue: Translational Research on Pain and Pain Management in Later Life

55/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

Key finding: Prevalence studies indicate that as many as 50% of older adults experience bothersome pain on a regular basis (Dahlhamer et al., 2018; Galicia-Castillo & Weiner, 2023; Larsson et al., 2017; Lin et al., 2020; Rikard et al., 2023). +4 more findings

• Clinical Trials

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Impact of diagnosis timing on AD cost and healthcare utilization

42/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Early-diagnosed patients (N = 421) have a lower utilization rate of inpatient skilled nursing facility, nursing home and hospitalization than late-diagnosed patients (N = 2817) after being diagnosed with AD. +4 more findings

• Care Services
• Diagnosis
• Policy

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Cognitive Screening Beliefs and Behaviors Among Older US Adults: Results from the National Poll on Healthy Aging

31/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Our primary outcome was self‐reported history of cognitive screening (never versus ever had screening). +4 more findings

• Diagnosis

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A Comprehensive, Community‐Engaged Recruitment Strategy to Increase Minority Representation in New IDEAS – an Amyloid Imaging Study

48/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: To ensure diversity, we developed a comprehensive recruitment strategy using a diverse, culturally‐trained staff that includes : • Identifying Dementia Specialists experienced recruiting minorities • Embedding high‐impact community engagement in select regions • Increasing capacity of specialists and PET facilities to engage minorities • Increasing pipeline of referrals to Dementia Specialists • Creating a culturally‐informed awareness campaign Result New IDEAS has enrolled 4,524 participants including 954 (21.1%) Black/African American, and 842 (18.6%) Hispanic/Latinx. +2 more findings

• Health Equity
• Brain Scans

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Characterize demographics, comorbidities and co‐medications in newly diagnosed United States (US) Alzheimer’s Disease patients using Medicare claims

36/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Extensive understanding of a drug’s real‐world target population can inform generalizability of clinical trial results and highlight unaddressed risk. +2 more findings

• Treatments

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Using a newly validated algorithm to estimate prevalence and incidence of Alzheimer’s Disease and related dementias in Medicare claims

33/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Using a fit‐for‐purpose validated algorithm, the 2019 annual prevalence and incidence of ADRD in the Medicare population aged 65+ with Part D enrollment was estimated to be 18% and 5.8% respectively.

• Policy
• Risk Factors

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DISPARITIES IN CONTINUITY OF CARE AND USE OF ANNUAL WELLNESS VISITS AMONG OLDER AMERICANS WITH DEMENTIA

35/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

Key finding: Compared to TM, MA increased the odds of annual wellness visits and reduced Hispanic-White disparity in annual wellness visits. +1 more finding

• Health Equity
• Policy

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Impact on End‐of‐life Planning of a Care Coordination Program for persons living with dementia

37/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: We enrolled 195 patients in the CARES dementia care program. +2 more findings

• Care Services

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Population‐based Dementia Identification and Care Coordination: The CS CARES Program

46/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: PLWD proactively enrolled in a dementia care program have high baseline rates of behavioral issues and their caregivers have elevated depression and stress scores. +1 more finding

• Care Services

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Incidence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population

30/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Among Medicare beneficiaries from 2008 to 2018, AD incidence generally decreased while MCI increased. +1 more finding

• Early Stage
• Policy
• Risk Factors

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Prevalence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population

32/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Among Medicare beneficiaries from 2008 to 2018, AD prevalence was generally stable, while MCI increased. +1 more finding

• Early Stage
• Policy

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Estimates of diagnosed dementia prevalence and incidence among diverse beneficiaries in Traditional Medicare and Medicare Advantage

36/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: Lower diagnosed dementia rates in MA compared to TM may exacerbate racial/ethnic disparities in diagnosed dementia. +3 more findings

• Risk Factors
• Health Equity
• Policy

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ACCESS TO NEIGHBORHOOD AMENITIES AND RISK OF INSTITUTIONALIZATION AMONG PERSONS WITH DEMENTIA

34/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: This may be due to caregiving challenges associated with the behavioral symptoms PWD exhibit and their reduced capacities to perform daily tasks. +4 more findings

• Lifestyle
• Care Services

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The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort

53/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in neurology

Key finding: The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. +3 more findings

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Neutrophil counts and cardiovascular disease

55/100 ✓ Peer-reviewed Long-term cohort studies European heart journal

Key finding: High neutrophil counts, an easily accessible inflammation biomarker, are associated with atherosclerosis in experimental studies. +3 more findings

• Risk Factors

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TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury

49/100 ✓ Peer-reviewed TREM2 and immune genetics Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: TREM2 regulates multiple microglial functions, including lipid metabolism, immune reaction, inflammation, and microglial phagocytosis. +3 more findings

• Genetics
• Brain Biology

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Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary

50/100 ✓ Peer-reviewed TREM2 and immune genetics Cancer discovery

Key finding: To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. +3 more findings

• Genetics

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Speech and language markers of neurodegeneration: a call for global equity

54/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Overall, we seek to inspire timely actions to counter a looming source of inequity in behavioural neurology.

• Other Dementias
• Health Equity

Full summary, score breakdown and related studies → Original source