alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,976–8,000 of 27,380 studies, newest first · page 320 of 1096.

February 2023 19

  1. 2023-02-02

    Cognitive interventions for memory and psychological well-being in aging and dementias

    ✓ Peer-reviewed Risk factors Frontiers in psychology

    Key finding: We also report results from a pilot study-AIM WARM-in which RT was combined with physical activity, specifically walking, for early-stage dementia.

    Full summary, score breakdown and related studies → Original source

  2. 2023-02-02

    Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements

    ✓ Peer-reviewed Genetics Cell genomics

    Key finding: We detected 319,861 significant correlations, or links, between gene expression and cell type-specific transposase accessible regions enriched for active CREs.

    Full summary, score breakdown and related studies → Original source

  3. 2023-02-02

    Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Genetics Nature neuroscience

    Key finding: As proof of principle, we analyze brain tissues of a mouse model of Alzheimer's disease at 8 and 13 months of age. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-02-02

    The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline

    ✓ Peer-reviewed Prevention trials Experimental gerontology

    Key finding: Among these risk factors, nutrition is key, as it is fundamental to healthy aging, and has interrelated benefits on a number of organ systems, metabolic processes and health states that can all contribute to modifying the risk of dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2023-02-01

    Associations of Air Pollution and Genetic Risk With Incident Dementia: A Prospective Cohort Study

    ✓ Peer-reviewed Risk factors American journal of epidemiology

    Key finding: No significant interaction between air pollution and genetics was found, either on the multiplicative scale or on the additive scale. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2023-02-01

    Social isolation is linked to classical risk factors of Alzheimer's disease-related dementias

    ✓ Peer-reviewed Risk factors PloS one

    Key finding: Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.

    Full summary, score breakdown and related studies → Original source

  7. 2023-02-01

    Late-life depression and multimorbidity trajectories: the role of symptom complexity and severity

    ✓ Peer-reviewed Risk factors Age and ageing

    Key finding: in multi-adjusted models, relative to individuals without depression, those with major (β per year: 0.33, 95% confidence interval [CI]: 0.06-0.61) and subsyndromal depression (β per year: 0.21, 95%CI: 0.12-0.30) experienced an accelerated rate of somatic multimorbidity accumulation, whereas those with minor depression did not. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-02 month only

    Brain Reserve, Resilience, and Cognitive Stimulation Across the Lifespan: How Do These Factors Influence Risk of Cognitive Impairment and the Dementias?

    ✓ Peer-reviewed Risk factors Clinics in geriatric medicine

    Key finding: In the absence of effective treatments for dementia, maintaining cognitive health in old age is one of the major challenges facing aging societies. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-02-01

    SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry

    ✓ Peer-reviewed Digital health tools Science advances

    Key finding: We present results on segmentation, registration, and atlasing of >10,000 scans of controls and patients with brain tumors, strokes, and Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2023-02-01

    Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease

    ✓ Peer-reviewed Risk factors JAMA neurology

    Key finding: Consistent with previous reports, risk factors and prodromal features associated with PD included traumatic brain injury, odds ratio (OR), 1.62; 95% CI, 1.36-1.92; alcohol misuse, OR, 1.32; 95% CI, 1.21-1.44; hypertension, OR, 1.29; 95% CI, 1.26-1.31; anosmia, OR, 2.16; 95% CI, 1.59-2.93; and parasomnias (including RBD), OR, 1.62; 95% CI, 1.42-1.84. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2023-02-01

    Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

    Key finding: To define Alzheimer's disease with biomarkers rather than clinical assessment, we assessed prediction of research-diagnosed disease status using these biomarkers and tested genetic variants associated with the biomarkers that may reflect more accurately the risk of biochemically defined Alzheimer's disease instead of the risk of dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2023-02-01

    Uptake of invitations to a lung health check offering low-dose CT lung cancer screening among an ethnically and socioeconomically diverse population at risk of lung cancer in the UK (SUMMIT): a prospective, longitudinal cohort study

    ✓ Peer-reviewed End-of-life care The Lancet. Public health

    Key finding: Overall, uptake was lower among men than among women (odds ratio [OR] 0·91 [95% CI 0·88-0·94]; p<0·0001), and higher among older age groups (1·48 [1·42-1·54] among those aged 65-69 years vs those aged 55-59 years; p<0·0001), groups with less deprivation (1·89 [1·76-2·04] for the most vs the least deprived areas; p<0·0001), individuals of Asian ethnicity (1·14 [1·09-1·20] vs White ethnicity; p<0·0001), and individuals who were former smokers (1·89 [1·83-1·95] vs current smokers; p<0·0001). +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2023-02-01

    The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

    Key finding: There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic strategies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-02-01

    Machine Learning for Dementia Prediction: A Systematic Review and Future Research Directions

    ✓ Peer-reviewed Digital health tools Journal of medical systems

    Key finding: It was observed that image data driven ML models yields promising results in terms of dementia prediction compared to other data modalities, i.e., clinical feature-based data and voice data.

    Full summary, score breakdown and related studies → Original source

  15. 2023-02-01

    ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711

    ✓ Peer-reviewed Biomarkers Molecular psychiatry

    Key finding: Furthermore, we found that the level of a composite biomarker, i.e., a combination of APP669-711/Aβ1-42 ratio and Aβ1-40/Aβ1-42 ratio in human plasma, correlates with the amyloid PET status of AD patients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2023-02-01

    Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: For all 4 phosphorylation sites assessed in CSF, p-tau was significantly more closely associated with amyloid-PET values than tau-PET values (p-tau181 difference, 13%; 95% CI, 3%-22%; P = .006; p-tau217 difference, 11%; 95% CI, 3%-20%; P = .003; p-tau231 difference, 15%; 95% CI, 5%-22%; P Conclusions and relevance Results of this cross-sectional study of 2 observational cohorts suggest that the p-tau abnormality as an early event in AD pathogenesis was associated with amyloid-β accumulation and highlights the need for careful interpretation of p-tau biomarkers in the context of the amyloid/tau/neurodegeneration, or A/T/(N), framework. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2023-02-01

    Association of Hearing Aids and Cochlear Implants With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis

    ✓ Peer-reviewed Prevention and risk JAMA Neurology

    Key finding: In this meta-analysis, the usage of hearing restorative devices by participants with hearing loss was associated with a 19% decrease in hazards of long-term cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2023-02-01

    Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea

    ✓ Peer-reviewed Prevention and risk JAMA Network Open

    Key finding: In this cohort study of a Korean population, decreased risk of dementia was associated with maintaining mild to moderate alcohol consumption, reducing alcohol consumption from a heavy to a moderate level, and the initiation of mild alcohol consumption, suggesting that the threshold of alcohol consumption for dementia risk reduction is low. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-02-01

    Association Between Consumption of Ultraprocessed Foods and Cognitive Decline

    ✓ Peer-reviewed Prevention and risk JAMA Neurology

    Key finding: A higher percentage of daily energy consumption of ultraprocessed foods was associated with cognitive decline among adults from an ethnically diverse sample. +4 more findings

    Full summary, score breakdown and related studies → Original source

January 2023 6

  1. 2023-01-31

    Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Consistent with previous in vitro findings, Trem2 H157Y increases TREM2 shedding with elevated soluble TREM2 levels in the brain and serum. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-01-31

    Rural and urban differences in quality of dementia care of persons with dementia and caregivers across all domains: a systematic review

    ✓ Peer-reviewed Digital health tools BMC health services research

    Key finding: This comprehensive portrait of rural-urban differences in dementia care highlights possible geographically based inequities and can be used by researchers and decision makers to guide development of more equitable dementia care policies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2023-01-31

    Cognitive stimulation to improve cognitive functioning in people with dementia

    ✓ Peer-reviewed Digital health tools The Cochrane database of systematic reviews

    Key finding: Where appropriate, we undertook subgroup analysis by modality (individual versus group), number of sessions and frequency, setting (community versus care home), type of control condition and dementia severity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-01-31

    Dementia prevention in memory clinics: recommendations from the European task force for brain health services

    ✓ Peer-reviewed Prevention and risk The Lancet regional health. Europe

    Key finding: Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles.

    Full summary, score breakdown and related studies → Original source

  5. 2023-01-31

    A Web-Based Decision Aid for Caregivers of Persons With Dementia With Firearm Access (Safe at Home Study): Protocol for a Randomized Controlled Trial

    ✓ Peer-reviewed Treatments JMIR research protocols

    Key finding: The S@H study is the first randomized trial of a firearm safety decision aid for ADRD caregivers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-01-31

    Focused Ultrasound-mediated Liquid Biopsy in a Tauopathy Mouse Model

    ✓ Peer-reviewed Biomarkers Radiology

    Key finding: In the 2-month-old mice, sonobiopsy significantly increased the normalized levels of plasma p-tau species compared with the conventional blood-based liquid biopsy (p-tau-181-to-mouse tau [m-tau] ratio: 1.7-fold increase, P = .006; p-tau-231-to-m-tau ratio: 1.4-fold increase, P = .048).

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →