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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,226–10,250 of 27,380 studies, newest first · page 410 of 1096.

May 2021 25

  1. 2021-05-12

    Atrial fibrillation and Alzheimer's disease: A conundrum

    ✓ Peer-reviewed Risk factors European journal of clinical investigation

    Key finding: Out of the 1328 papers initially retrieved, 431 duplicates and 216 records in languages other than English were removed; thus, only 98 papers were included in our research material. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-05-12

    Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial

    ✓ Peer-reviewed Drug development The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Fifty-eight of 77 patients (75.3%) completed the trial. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-05-12

    TREM2 promotes natural killer cell development in CD3-CD122+NK1.1+ pNK cells

    ✓ Peer-reviewed TREM2 and immune genetics BMC immunology

    Key finding: Here, we demonstrated for the first time that CD3-CD122+NK1.1+ precursor NK (pNK) cells expressed TREM2 and their population increased in TREM2-overexpressing transgenic (TREM2-TG) mice compared with that in female C57BL/6 J wild type (WT) mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-05-11

    VEGF counteracts amyloid-β-induced synaptic dysfunction

    ✓ Peer-reviewed Disease mechanisms Cell reports

    Key finding: These findings provide evidence for alterations of the VEGF pathway in AD models and suggest that restoring VEGF action on neurons may rescue synaptic dysfunction in AD.

    Full summary, score breakdown and related studies → Original source

  5. 2021-05-11

    Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Our analyses demonstrate lower retinal capillary densities in early disease, in cognitively normal APOE ε4 gene carriers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-05-11

    ESO Guideline on covert cerebral small vessel disease

    ✓ Peer-reviewed Prevention and risk European stroke journal

    Key finding: We found little direct evidence, mostly of low quality. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-05-10

    Memory care approaches to better leverage capacity of dementia specialists: a narrative synthesis

    ✓ Peer-reviewed Health systems and care delivery Neurodegenerative disease management

    Key finding: Prior research suggests that a scarcity of dementia specialists could hamper access to disease-modifying Alzheimer's treatments.

    Full summary, score breakdown and related studies → Original source

  8. 2021-05-10

    Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Nature communications

    Key finding: Both approaches revealed significantly elevated E/I ratios for AD, but not DS, versus controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-05-10

    The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats

    ✓ Peer-reviewed Risk factors Environmental health perspectives

    Key finding: These data demonstrate that chronic exposure to ambient TRAP promoted AD phenotypes in wildtype and genetically susceptible rats. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-05-10

    Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy

    Key finding: The FBB threshold based on the young sample (1.08; 18 CL) was consistent with that of the data-driven approach (1.10; 21 CL), and the existing FBP threshold converted to CL with the derived transformation (1.11; 20 CL). +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-05-10

    Digital Biomarkers of Cognitive Frailty: The Value of Detailed Gait Assessment Beyond Gait Speed

    ✓ Peer-reviewed Digital health tools Gerontology

    Key finding: Dual-task gait and other detailed gait metrics provide value for identifying CF above gait speed alone.

    Full summary, score breakdown and related studies → Original source

  12. 2021-05-09

    Quality of Education and Late-Life Cognitive Function in a Population-Based Sample From Puerto Rico

    ✓ Peer-reviewed Risk factors Innovation in aging

    Key finding: Quality of education was positively correlated with both educational attainment and cognitive performance. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-05-08

    Role of microbiota-derived short-chain fatty acids in nervous system disorders

    ✓ Peer-reviewed Vascular contributions Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: It has been shown that gut bacterial dysbiosis can cause pathology and altered bacterial metabolites' formation, resulting in dysregulation of the immune system and metabolism. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-05-07

    Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: Conventional MCI criteria were insufficient to allow for the creation of well-defined and internationally comparable samples of MCI patients.

    Full summary, score breakdown and related studies → Original source

  15. 2021-05-06

    The Effects of Aerobic Exercise in Patients with Early-Onset Dementia: A Scoping Review

    ✓ Peer-reviewed Prevention trials Dementia and geriatric cognitive disorders

    Key finding: Early-onset dementia (EOD) defines all dementia related conditions with an onset before the age of 65 years. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-05-06

    Effect of Cognitive Training in Fully Immersive Virtual Reality on Visuospatial Function and Frontal-Occipital Functional Connectivity in Predementia: Randomized Controlled Trial

    ✓ Peer-reviewed Prevention trials Journal of medical Internet research

    Key finding: However, the results of recent studies using semi-immersive virtual reality (VR)-assisted cognitive training are inconsistent. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-05-05

    Anticancer drugs repurposed for Alzheimer's disease: a systematic review

    ✓ Peer-reviewed Drug development Alzheimer's research & therapy

    Key finding: Based on a structured search on the ClinicalTrials.gov and the EudraCT databases, we identified 13 clinical trials testing 11 different approved anticancer agents (five tyrosine kinase inhibitors, two retinoid X receptor agonists, two immunomodulatory agents, one histone deacetylase inhibitor, and one monoclonal antibody) in the AD continuum. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-05-05

    Cortical [18 F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes

    ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society

    Key finding: Twenty-four percent (11 of 45) were β-amyloid-positive. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-05-05

    Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline

    ✓ Peer-reviewed Brain tissue and pathology Journal of the American Geriatrics Society

    Key finding: We examined whether sarcopenia is associated with the occurrence of late-life cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-05-05

    Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau

    ✓ Peer-reviewed Brain tissue and pathology EMBO molecular medicine

    Key finding: Plasma levels of phospho-tau217 (P-tau217) accurately differentiate Alzheimer's disease dementia from other dementias, but it is unclear to what degree this reflects β-amyloid plaque accumulation, tau tangle accumulation, or both. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-05-04

    Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase

    ✓ Peer-reviewed Treatments Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: Its prevalence is likely to increase in any aging population and will be a major burden on healthcare system by the mid of the century. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-05-04

    Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy

    Key finding: Across different tau biomarker groups, the proportion of participants with a discordant profile varied (plasma+/CSF- 15.6%, plasma-/CSF+ 15.3%, plasma+/PET- 22.4%, and plasma-/PET+ 6.1%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-05-04

    A genome-wide association study of plasma phosphorylated tau181

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: No loci, other than those within the APOE genomic region (lead variant = rs429358, beta = 0.32, p =8.44 × 10-25) demonstrated association with P-tau181 at genome-wide significance (p < 5 × 10-08), though rs60872856 on chromosome 2 came close (beta = -0.28, p = 3.23 × 10-07, nearest gene=CYTIP). +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-05-04

    Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: A systematic review

    ✓ Peer-reviewed Digital health tools Human brain mapping

    Key finding: We conducted a systematic review aimed at determining the diagnostic power of rs-fMRI to identify FC abnormalities in the DMN of patients with AD or MCI compared with healthy controls (HCs) using machine learning (ML) methods. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-05-04

    Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Genome medicine

    Key finding: Alzheimer's disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →