Newest studies

Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: We identified four genome-wide significant loci associated with DKI markers at chr3p25.1 (LINC00620-WNT7A), chr5q14.2 (VCAN), chr5q14.3 (VCAN-AS1) and chr8q24.21 (CCDC26), and 11 additional suggestive loci. +4 more findings

• Brain Scans
• Genetics
• Other Dementias

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Effect of a PROtein-enriched MEDiterranean diet and EXercise (PROMED-EX) on nutritional status and cognitive performance in older adults at risk of undernutrition and cognitive decline: the PROMED-EX randomized controlled trial

49/100 ✓ Peer-reviewed Prevention trials American Journal of Clinical Nutrition

Key finding: At baseline, the mean MNA score was 22.5 ± 2.3. +4 more findings

• Lifestyle
• Clinical Trials

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Network connectivity and amyloid-β align with tau in atypical Alzheimer disease subtypes

46/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer s Research & Therapy

Key finding: Converging evidence suggests that accumulation may be driven by spreading through network connections and/or interactions with amyloid-β (Aβ). +1 more finding

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Chronic Disease and Disability in the United States: Trends, Inequities, and Imperatives for Policy Reform

34/100 ✓ Peer-reviewed Risk factors Milbank Quarterly

Key finding: In 2023, US life expectancy reached 78.5 years and healthy life expectancy 64.5 years, both still below prepandemic 2019 levels, with a persistent 13-14-year gap between life expectancy and healthy life expectancy. +4 more findings

• Risk Factors
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

A Phase 2b randomized clinical trial of the oral p38α inhibitor neflamapimod in dementia with Lewy bodies (DLB)

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers Research Square

Key finding: There is high unmet need in dementia with Lewy bodies (DLB). +3 more findings

• Clinical Trials
• Other Dementias
• Biomarkers

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Point Prevalence of Common Mental Health Conditions in Nigeria: A Systematic Review and Meta-Analysis

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: These estimates are planning values for populations resembling the contributing studies, not national population rates. +1 more finding

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Gut community-level analysis reveals an altered balance between Phocaeicola vulgatus and Bacteroides fragilis in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Our findings suggest that AD-associated gut microbiome variation extends beyond taxon-specific abundance to the balance between specific species within a community matrix.

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsy

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Our findings indicate that HFOs likely arise from different neuronal populations and are generated through distinct mechanisms in these two models. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Repurposing probucol for prevention of dementia: a nationwide cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: In this nationwide cohort, probucol use was associated with substantially lower dementia risk than statins, supporting evaluation of probucol for repurposing in dementia prevention. +1 more finding

• Prevention

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The missing improvers: Tau pathology, neuroplasticity, and the case for tau-informed patient selection before amyloid immunotherapy

26/100 ✓ Peer-reviewed Health systems and care delivery The journal of prevention of Alzheimer's disease

Key finding: Amyloid immunotherapy with lecanemab and donanemab has been approved on the basis of statistically significant slowing of cognitive and functional decline in early Alzheimer's disease (1,2). +1 more finding

• Treatments
• Brain Biology

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Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia

47/100 ✓ Peer-reviewed Genetics The Journal of Prevention of Alzheimer s Disease

Key finding: Higher AD-PRS was associated with faster CD in the full clinical cohort and in biomarker subset, independently of APOE genotype. +4 more findings

• Genetics

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Effect of glycosylated hemoglobin on cognitive impairment related to White Matter Hyperintensity in non diabetes patients: A retrospective study

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: HbA1c levels had warning value for cognitive impairment in non diabetes patients with WMH, and a nonlinear correlation exists between HbA1c and WMH-related cognitive impairment. +2 more findings

• Diagnosis
• Brain Scans
• Risk Factors

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Deep Learning-Derived Insulin Resistance Index for Cardiovascular Risk Prediction: A Prospective Cohort Study with External Validation in Chinese and US Populations

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv

Key finding: The MoE-derived DNN-IR index demonstrated robust and stable performance in predicting atherosclerosis, incident CVD, cardiovascular mortality, and all-cause mortality in the general population. +2 more findings

• Risk Factors
• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Anthropometric Status, Dietary Diversity, and Diet Quality in Relation to Cognitive Performance in Older Turkish Adults: A Cross-Sectional Study

64/100 ✓ Peer-reviewed Prevention and risk Journal of clinical medicine

Key finding: 53.0% of the participants were in the group of possible mild cognitive impairment (MCI). +4 more findings

• Lifestyle

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Effectiveness of Modern Diagnostic and Therapeutic Interventions for Major Neurological Disorders: A Systematic Literature Review

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: From 464 identified records, 30 peer-reviewed primary studies met all eligibility criteria following the exclusion of low-quality sources and unindexed preprints. +2 more findings

• Treatments
• Diagnosis

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers

46/100 ✓ Peer-reviewed Mild cognitive impairment Science Advances

Key finding: Plasma Aβ42/40, p-tau217, and tau PET each conferred higher risk, while hippocampal volume did not.

• Early Stage
• Biomarkers
• Brain Scans

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Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD mice

33/100 ✓ Peer-reviewed Genetics Biology of Sex Differences

Key finding: These findings suggest that sexual differentiation in early life has modest effects on adult development of AD in females, a relationship that appeared stronger in the context of APOE4 . +3 more findings

• Genetics
• Brain Biology

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Prognostic significance of cerebrospinal fluid tau biomarkers in amyloid-negative A-T + N + neurodegeneration: A retrospective cohort study

47/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

Key finding: Survival was assessed using Kaplan-Meier analysis, and predictors of mortality were evaluated using Cox models. +3 more findings

• Biomarkers

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Artificial intelligence education for health science and non-STEM students: a mixed- methods evaluation of an interdisciplinary mental health prototype development program

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: This interdisciplinary, prototype-centered AI education program was associated with significant short-term improvements in students’ perceived AI knowledge, digital mental health readiness, interdisciplinary collaboration, innovation capacity, STEM career readiness, and solution-design ability. +3 more findings

• Digital Tools

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Active amyloid beta immunization ameliorates synapse loss and phosphorylated-tau accumulation around remaining plaques for up to 14 years after treatment

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Amyloid plaques, one of the defining features of Alzheimer’s disease, are associated with synapse loss and accumulation of pathological tau in dystrophic neurites and reactive glia in their immediate vicinity. +2 more findings

• Brain Biology
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-β Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: Concordance between p-tau217 and Aβ was high in the AD and MCI groups (observed agreement 90.0% in each), but overall agreement across Cohort II was modest (166/351, 47.3%; Cohen's κ = 0.117, 95% CI 0.029–0.204). +2 more findings

• Biomarkers
• Diagnosis

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Population-based reference equations and Z-scores for blood biomarkers of neurodegenerative diseases

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: Blood biomarkers are increasingly used to support the diagnosis and monitoring of neurodegenerative diseases. +3 more findings

• Biomarkers

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Differential associations of insulin resistance with anterior hippocampal volume in mild cognitive impairment and Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment bioRxiv

Key finding: Insulin resistance is increasingly recognized as a metabolic factor associated with Alzheimer’s disease (AD); however, its relevance to hippocampal structural changes—a key pathological feature of AD—across disease stages is not fully understood. +3 more findings

• Diagnosis
• Brain Scans
• Early Stage

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Biologically Constrained Continuous-Time Framework for Long-Horizon Cognition Forecasting in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: These results demonstrate that embedding biological disease mechanisms within continuous-time deep learning improves the accuracy, biological plausibility, and clinical utility of long-horizon cognitive forecasting.

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Association of age with clinical progression across plasma p-tau217 levels

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: STRUCTURED ABSTRACT BACKGROUND Chronological age and plasma p⍰tau217 each predicts cognitive decline, but whether their prognostic associations interact is unclear. +3 more findings

• Biomarkers

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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