alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 876–900 of 27,380 studies, newest first · page 36 of 1096.

July 2026 25

  1. 2026-07-27

    Validation of the self-test computerised PROTECT Cognitive Test System for detection of dementia and Mild Cognitive Impairment

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv

    Key finding: An optimised detection algorithm robustly identified MCI (P<0.001) and predicted 24-month decline across cognitive domains in both amnestic MCI and non-amnestic MCI phenotypes compared with healthy controls.

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-07-27

    Navigating young-onset dementia caregiving: A qualitative study of unmet needs, support, and resilience

    ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

    Key finding: Although caregivers demonstrated resilience and adaptive coping, YOD caregiving in Singapore remained constrained by limited access to visible, tailored, and age-appropriate support. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-07-27

    Comparator supplement patterns qualify the clinical interpretation of an EHR-derived glucosamine signal in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv

    Key finding: Among participants with dementia, glucosamine records were not associated with higher adjusted mortality, although death-data limitations reduce certainty. +1 more finding

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-07-27

    Diphenhydramine Disrupts Sleep Architecture in 5XFAD Alzheimer’s Disease Model and Wild-Type Mice

    ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

    Key finding: Overall, chronic DPH use degrades sleep quality and increases fragmentation in both WT and AD-model mice, which questions the use of sedating anticholinergics as sleep aids, especially in AD.

    Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-07-27

    Subacute and Chronic Cognitive and Cerebrovascular Functional Consequences of Mild Traumatic Brain Injury in Rats

    ⚠ Preprint — not yet peer-reviewed Prevention trials bioRxiv

    Key finding: Compared to sham response at 10 weeks, there was impaired arterial constriction response to 90 mm Hg intraluminal pressure in mTBI rats at 10 weeks and in sham and mTBI rats at 12 months, with no difference seen in response to angiotensin II or DETA-NONOate exposure.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-07-27

    Computational Screening of FDA-Approved Drugs as Potential BACE1 Inhibitors for Alzheimer's Disease Drug Repurposing

    ⚠ Preprint — not yet peer-reviewed Treatments Research Square

    Key finding: Minocycline demonstrated the strongest binding affinity at - 9.1 kcal/mol, followed by Rosiglitazone at -8.2 kcal/mol and Sertraline at -7.5 kcal/mol. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-07-27

    Serial amyloid PET demonstrates marked reduction in amyloid burden following donanemab treatment: a real-world cohort study

    ✓ Peer-reviewed Brain scans and imaging Japanese journal of radiology

    Key finding: Centiloid values significantly decreased from 52.3 ± 23.4 at baseline to - 5.6 ± 16.5 at follow-up, with a mean change of - 58.0 (p < 0.001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2026-07-27

    Attitudes and Decisional Conflict in Family Caregivers of Persons With Dementia: A Mediating Role of Perceived Benefits of Advance Care Planning

    ✓ Peer-reviewed End-of-life care Journal of Applied Gerontology

    Key finding: More positive attitudes were associated with lower decisional conflict directly and indirectly through perceived benefits. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2026-07-27

    A 60-second interpretable voice model for early dementia screening

    ✓ Peer-reviewed Cognitive tests and assessment PLOS Digital Health

    Key finding: Early detection of cognitive impairment in assisted living is hindered by time-intensive tools like MMSE and MoCA. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2026-07-27

    Is Tau Acetylation a Key to Frontotemporal Lobar Degeneration Diagnosis?

    ✓ Peer-reviewed Tau biomarkers Clinical Chemistry

    Key finding: This can be the result of a mutation in the microtubule-associated protein tau (MAPT) gene, hyperphosphorylation, or other, not yet known, reasons.

    Full summary, score breakdown and related studies → Original source

  11. 2026-07-27

    Sustained fish intake and 21-year Alzheimer's disease risk: a target trial emulation

    ✓ Peer-reviewed Prevention and risk American Journal of Epidemiology

    Key finding: Substituting fish for meat yielded similar results. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2026-07-25

    Chronic orexin receptor antagonism is associated with rescued sleep and agitation-like behaviour in tau transgenic PS19 mice, but sex-dependently improved cognition

    ⚠ Preprint — not yet peer-reviewed Risk factors Authorea Preprints

    Key finding: DORA-22 and MK-1064 rescued tauopathy-related sleep loss, and reduced agitation-like locomotion and stress-induced hyperthermic responses. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-07-25

    Bedside screening and assessment tools for sarcopenia, dysphagia and malnutrition in older adults with dementia: a scoping review

    ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

    Key finding: From 12,770 records, 3,636 duplicates were removed and 9,134 titles and abstracts were screened. +4 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-07-25

    Common Dysregulated Pathways and Genes in Alzheimer’s, Parkinson’s, and Huntington’s Diseases: A Computational Analysis to Nominate Candidate Gene Targets for Drug Repurposing

    ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

    Key finding: They were significantly upregulated across all three diseases and involved in the shared pathways.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-07-25

    Exploring the Therapeutic Potential of Chalcones in Alzheimer’s Disease: Mechanistic Insights and SAR Perspectives

    ✓ Peer-reviewed Treatments Mini-Reviews in Medicinal Chemistry

    Key finding: Overall, chalcone-based MTDLs provide a rational framework for the development of next-generation anti-Alzheimer agents.

    Full summary, score breakdown and related studies → Original source

  16. 2026-07-24

    GLP-1 Receptor Agonists vs SGLT2 Inhibitors for Alzheimer’s Disease Risk in Type 2 Diabetes: A Systematic Review and Meta-Analysis

    ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

    Key finding: These findings reinforce the potential of GLP-1RAs and SGLT2i as therapeutic options to slow cognitive decline in DM2, possibly depending on glycemic control and central modulation. +4 more findings

    Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-07-24

    Cobalt-Based Drug Delivery to the Brain using Rapid Short-Pulses of Focused Ultrasound and Microbubbles reduces Aβ aggregation in 5XFAD mice

    ⚠ Preprint — not yet peer-reviewed Treatments Research Square

    Key finding: Immunohistochemistry demonstrated a 60.5% reduction in Aβ plaque area in mice receiving combined focused ultrasound and CoLAm2 compared with ultrasound-only, drug-only, and untreated controls. +1 more finding

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-07-24

    Decreased Plasma IGF-1 Is Associated with Cortical Atrophy, But Not Concomitant Cerebrovascular Disease in Alzheimer’s Dementia

    ⚠ Preprint — not yet peer-reviewed Biomarkers Preprints.org

    Key finding: Plasma IGF-1 levels were significantly lower in AD compared to NCI and CIND participants (both p < 0.001). +2 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-07-24

    Aluminum and Alzheimer's disease in the 21st century: An umbrella review of evidence and controversies

    ✓ Peer-reviewed Inflammation and the immune system Neurotoxicology

    Key finding: The evidence reviewed indicates that Al can promote several AD-related biological processes in experimental settings, including oxidative stress, mitochondrial dysfunction, neuroinflammation, glial activation, disrupted calcium signaling, amyloid beta aggregation, impaired amyloid clearance, tau phosphorylation, autophagy impairment, and epigenetic alterations. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2026-07-24

    Clinical features of older MS patients with and without Alzheimer disease biomarkers

    ✓ Peer-reviewed Treatments Multiple Sclerosis and Related Disorders

    Key finding: Recent work suggests that biomarkers indicative of Alzheimer's disease (AD) are markedly reduced in people with MS. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2026-07-23

    Associations of lifestyle factors and genetic risk with risk and rate advancement periods of dementia

    ⚠ Preprint — not yet peer-reviewed Prevention and risk PsyArXiv

    Key finding: Rate advancement periods were used to quantify the association between these factors and advancing or delaying incidence rate relative to age.RESULTSOver median follow-up of 13.6 years, versus neutral APOE ε3ε3, ε4 presence advanced dementia risk by 5.58 years whereas ε2 presence delayed by 1.08 year (q<0.001). +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-07-23

    Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-β clearance in Alzheimer’s disease models

    ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

    Key finding: Here, we showed that exposure of primary mouse microglia and human induced pluripotent stem cell-derived microglia (iMGLs) to 3–100 µg/mL diesel exhaust particles (DEP) disrupted microglial homeostasis, induced morphological abnormalities, increased reactive oxygen species, impaired lysosomal degradation, and led to a concentration-dependent loss of phagocytic capacity. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-07-23

    Dynamic Interrelationships Among Physical Activity, Cognitive Function, and Depression in Older Adults: A Random-Intercept Cross- Lagged Panel Analysis

    ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

    Key finding: When stable individual differences are accounted for, depressive symptoms emerge as a stronger within-person temporal predictor of cognitive decline than physical activity. +3 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-07-23

    Multi-Domain Machine Learning of VR-synchronised directional EEG phase connectivity reveals candidate Alzheimer's continuum biomarkers

    ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

    Key finding: These findings suggest that VR-EEG directional connectivity provides a reproducible framework for identifying candidate electrophysiological biomarkers of the AD continuum, warranting validation in larger biomarker-confirmed cohorts.

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-07-23

    New Alzheimer’s Disease Diagnostics and Psychological Clinical Perspectives

    ⚠ Preprint — not yet peer-reviewed Clinical trials PsyArXiv

    Key finding: Phase 1 encompasses universal prevention through psychoeducation, cognitive reserve promotion, and emotional education. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →