Newest studies

Rhabdomyolysis Secondary to Reactivated Herpes Simplex Virus Type 1 Coinfected with Klebsiella pneumoniae in an Elderly Patient: A Case Report

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk Research Square

Key finding: After targeted anti-infection therapy, sufficient fluid resuscitation combined with nutritional and immune supportive care, the patient’s creatine kinase and inflammatory biomarkers normalized, and clinical status improved gradually. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Treatment of obstructive sleep apnea may contribute to long-term stabilisation of memory in Alzheimer's and vascular dementia

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Controlling for baseline differences, treatment of OSA improved delayed recall and may reduce the slope of memory decline in Alzheimer’s disease and vascular dementia. +2 more findings

• Treatments
• Early Stage
• Other Dementias

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cognitive Stimulation and Training in People with Mild-to-Moderate Alzheimer’s Disease: A Scoping Review

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Preprints.org

Key finding: Of 352 records identified, five studies involving 245 participants were included. +4 more findings

• Lifestyle

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A New Frontier in CWD Detection: Antemortem Plasma Biomarkers and Behavioral Profiling in Transgenic Mouse Models

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: Analyses at 90, 132, 174, and 230 days post-CWD inoculation show distinct biomarker elevation, with all three biomarkers significantly elevated in the CWD animals by 132 days post-inoculation. +1 more finding

• Biomarkers
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Social isolation, loneliness, and blood-based AD/ADRD biomarkers in a nationally-representative study of middle-aged and older adults

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Social isolation was associated with elevated blood-based biomarkers of neuronal injury, with variation by patterns of exposure over time. +4 more findings

• Biomarkers
• Lifestyle

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Palliative care documentation in gastrointestinal bleeding hospitalizations: national trends and associated care patterns

41/100 ✓ Peer-reviewed End-of-life care Baylor University Medical Center Proceedings

Key finding: Among 2,435,099 weighted hospitalizations, palliative care documentation was present in 65,675 (2.70%), increasing from 2.13% in 2016 to 3.43% in 2022. +4 more findings

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Plasma Biomarkers for Neocortical Tau Burden

55/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: The study included 560 amyloid-positive participants (BioFINDER: n = 431; mean [SD] age, 73.6 [7.0] years; 212 female [49.2%] and 219 male [51.8%]; TRIAD: n = 129; mean [SD] age, 70.4 [8.3] years; 76 female [58.9%] and 53 male [41.1%]). +4 more findings

• Biomarkers

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Social and socioeconomic factors and cognitive outcomes in multiple sclerosis

42/100 ✓ Peer-reviewed Risk factors Multiple Sclerosis and Related Disorders

Key finding: Non-White race and adverse social and socioeconomic factors-lower education, unemployment, unmarried status, and greater neighborhood disadvantage-were each associated with poorer cognitive performance (p < 0.05). +3 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Stress-Specific Mitochondrial Reserve as a Candidate Modifier of Lipid-Driven Synaptic Failure in Alzheimer Disease

66/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: A recent randomized trial demonstrated clear cerebrospinal-fluid DHA target engagement without detectable improvement in cognition or brain volume over 24 months. +4 more findings

• Brain Biology
• Clinical Trials

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Stress-Specific Mitochondrial Reserve as a Candidate Modifier of Lipid-Driven Synaptic Failure in Alzheimer Disease

45/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: A recent randomized trial demonstrated clear cerebrospinal-fluid DHA target engagement without detectable improvement in cognition or brain volume over 24 months. +4 more findings

• Brain Biology
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer’s disease continuum

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment bioRxiv

Key finding: While loss of NMDA receptors (NMDARs) is associated with Alzheimer’s disease (AD) severity, the effect of sex or the relationship between regional NMDAR density and antemortem cognitive status across the AD spectrum has not been examined. +2 more findings

• Diagnosis

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Conditional Latent Diffusion for Synthetic Brain MRI in Alzheimer’s Disease: A Preprocessing-Focused Pipeline

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Preprints.org

Key finding: A classifier trained only on synthetic data achieved an area under the curve (AUC) of 0.754 (95% CI, 0.60 to 0.91), compared with 0.810 for real data.

• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Gut Microbial Metabolism as a Dynamic Interface in Neurodegenerative Diseases

57/100 ✓ Peer-reviewed Disease mechanisms Metabolites

Key finding: SCFAs modulate epigenetic processes linked to Aβ and tau lesions. +4 more findings

• Brain Biology

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Relationships Among Hearing, Auditory Processing, and Cognition: A Study of Older Adults

41/100 ✓ Peer-reviewed Risk factors Audiology research

Key finding: DSI emerged as a significant predictor across both MoCA and CBB, surpassing the predictive power of both types of PTAs. +2 more findings

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The effectiveness and safety of high-intensity interval training, yoga and intermittent hypoxia-hyperoxia exposure on cognitive performance and health in individuals with mild cognitive impairment (KAYH): a study protocol for a randomized, sham-controlled trial

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials medRxiv

Key finding: Individuals diagnosed with mild cognitive impairment (MCI) have an increased risk of developing dementia.

• Clinical Trials
• Side Effects
• Early Stage

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Randomized metformin and cognitive outcomes in the Diabetes Prevention Program Outcomes Study

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Long-term metformin treatment is associated with a reduced risk of dementia and better memory performance among persons with pre-diabetes or T2D. Longer follow-up with more dementia cases is needed to confirm our findings. +4 more findings

• Risk Factors
• Prevention
• Clinical Trials

Scored 55 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Mapping Amyloid-PET Uptake in the White Matter in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: This study investigated whether WM measures derived from amyloid-PET are associated with AD biomarkers and to determine whether they offer added diagnostic and prognostic value beyond established biomarkers. +4 more findings

• Brain Scans

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Arterial Spin‐Labeling MRI at the Cortical‐ CSF Interface: A Novel Biomarker in Alzheimer Disease

41/100 ✓ Peer-reviewed Brain scans and imaging Annals of Clinical and Translational Neurology

Key finding: A total of 51 patients with AD, age (median: 73 years) and 53 cognitively normal subjects (median age: 69) were included. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Sensitivity and specificity of the CANTAB Paired Associates Learning test for identifying mild cognitive impairment

37/100 ✓ Peer-reviewed Getting a diagnosis Acta Psychologica

Key finding: Although the small sample size may have influenced the results, the findings suggest that the PAL demonstrated good diagnostic accuracy for distinguishing participants with MoCA-defined MCI.

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Clinical Practice Outcomes With Lecanemab for Alzheimer Disease

41/100 ✓ Peer-reviewed Treatments Neurology Open Access

Key finding: ε4 noncarriers and those with lower baseline amyloid burden. +4 more findings

• Treatments

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Plasma P-tau217 for detecting amyloid clearance after donanemab in Alzheimer's disease

54/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Despite reductions in plasma p-tau217 with donanemab treatment, this biomarker cannot currently be used to accurately detect TRAC by PET (< 24.1 CL) in individuals with early symptomatic AD.

• Biomarkers
• Clinical Trials
• Treatments

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APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Further analyses of the null and other mutant lines indicate that APP likely impacts these two distinct steps by two different mechanisms. +3 more findings

• Down Syndrome
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Diffusion MRI of Gray Matter Microstructural Profiles in Healthy Aging

57/100 ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews

Key finding: This methodology has historically been applied only to white matter tissue in the research context, but more recent literature suggests that diffusion MRI can also be applied to study microstructural alterations of gray matter tissue, including in healthy aging.

• Brain Scans
• Lifestyle

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Discovery of Natural Cholinesterase Inhibitors via Integrated Computational Studies using Labdane-Related Diterpenoids-based Pharmacophore Model and in-vitro studies

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: In recent years, labdane- related diterpenoids have attracted significant attention for their reported anticholinesterase efficacy, in tandem with their anti-inflammatory, antioxidant, and neuroprotective properties. +2 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Semaglutide Activates the Orexin/Hypocretin and Basal Forebrain Cholinergic Systems and Increases Acetylcholine Levels in the Hippocampus of Young and Aged Rats

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: We found that the orexin/hypocretin and basal forebrain cholinergic systems are activated following acute semaglutide administration in male and female young adult rats (3-5 months). +1 more finding

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source