Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia
Berta Calm, Adrián Hinojosa-Calleja, Fernando García‐Gutiérrez, Josep Blázquez-Folch, Montserrat Alegret, Maria Victoria Fernández, Itziar de Rojas, Pablo García‐González et al.. The Journal of Prevention of Alzheimer s Disease, 2026-08-13
Topic: Amyloid, tau and blood-test diagnosis
Higher AD-PRS was associated with faster CD in the full clinical cohort and in biomarker subset, independently of APOE genotype. AD-PRS was not associated with baseline MMSE. APOE ε4 was associated with lower baseline MMSE and faster CD only in the full clinical sample. Genetic predictors provided limited improvement beyond CSD variables, and model performance showed limited reproducibility across cohorts. AD-PRS is associated with longitudinal CD across the AD spectrum. Although polygenic burden contributes to variability in cognitive trajectories, its added predictive value beyond routinely available clinical variables remains modest.
Key findings
- Higher AD-PRS was associated with faster CD in the full clinical cohort and in biomarker subset, independently of APOE genotype.
- AD-PRS was not associated with baseline MMSE.
- APOE ε4 was associated with lower baseline MMSE and faster CD only in the full clinical sample.
- Genetic predictors provided limited improvement beyond CSD variables, and model performance showed limited reproducibility across cohorts.
- AD-PRS is associated with longitudinal CD across the AD spectrum.
Why it matters
A higher Alzheimer polygenic risk score was linked to faster cognitive decline over time, independent of APOE genotype, but it did not predict baseline cognitive test scores. The added predictive value beyond routinely available clinical variables was modest, and model performance was not consistently reproducible across cohorts.
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Study details
- Study designlongitudinal study
- Participants7,233
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease) |
| Journal's citation record | 0 / 4 | The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 3 / 4 | 7,233 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Sergi Valero: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Universitat de Barcelona: institution h-index 1,049 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 42594416) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.tjpad.2026.100658
- PubMed: 42594416
- Original source →
- Free full text: The Journal of Prevention of Alzheimer s Disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Calm, B., Hinojosa-Calleja, A., García‐Gutiérrez, F., Blázquez-Folch, J., Alegret, M., Fernández, M. V., et al. (2026). Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2026.100658
Vancouver
Calm B, Hinojosa-Calleja A, García‐Gutiérrez F, Blázquez-Folch J, Alegret M, Fernández MV, et al. Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia. The Journal of Prevention of Alzheimer s Disease. 2026. doi:10.1016/j.tjpad.2026.100658. PMID: 42594416.
BibTeX
@article{calm2026-42594416,
author = {Calm, Berta and Hinojosa-Calleja, Adrián and García‐Gutiérrez, Fernando and Blázquez-Folch, Josep and Alegret, Montserrat and Fernández, Maria Victoria and de Rojas, Itziar and García‐González, Pablo and others},
title = {{Predictive value of the Alzheimer polygenic risk score on cognitive decline in patients with mild cognitive impairment and Alzheimer's disease dementia}},
journal = {The Journal of Prevention of Alzheimer s Disease},
year = {2026},
doi = {10.1016/j.tjpad.2026.100658},
pmid = {42594416},
url = {https://doi.org/10.1016/j.tjpad.2026.100658}
}
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