Newest studies

Living arrangements shape the determinants of life-sustaining treatment preferences among Korean older adults

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

Key finding: Although most Korean older adults declined LST regardless of living arrangement, determinants of LST preferences differed according to household structure. +4 more findings

• End-of-Life Care
• Treatments

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: Compared with GBS, MFS patients showed higher BD-tau (12.7 vs 3.0 pg/mL, p=0.003), lower big tau (5.4 vs 11.4 pg/mL, p=0.002), and higher NfL levels, although the latter did not reach statistical significance (118.3 vs 32.5 pg/mL, p=0.16). +2 more findings

• Biomarkers

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A multimodal investigation of perceptual awareness in Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: A visual masking paradigm examined visual awareness negativity (VAN) and late positive (LP) electrophysiological responses and activation in visual cortex and fronto-parietal regions; and a complex audio-visual (movie) task examined activation in fronto-parietal networks previously associated with perceptual awareness. +3 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Meta-analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: Meta-analyses revealed dysregulated glucose metabolism as a unifying feature across A2NDs and included both hypo- and hypermetabolic patterns. +1 more finding

• Brain Scans
• Other Dementias

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Treatment response biomarkers in early Alzheimers disease: longitudinal trajectories, sample size estimates, and the impact of progression variability

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: The effects of heterogeneity over time were approximately twice as large in plasma compared to CSF.

• Biomarkers
• Treatments
• Clinical Trials

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A data-driven regional amyloid PET score predicts cognitive decline beyond Centiloid

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: The fixed nine-region weights were applied without retraining in a cross-tracer ADNI [18F]florbetaben subset (N = 71; largely overlapping the discovery participants) and two external validation cohorts, NACC SCAN (N = 1531; four tracers) and OASIS-3 (N = 428). +4 more findings

• Brain Scans

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Lecanemab (Leqembi)

28/100 ✓ Peer-reviewed Treatments Canadian Journal of Health Technologies

Key finding: Leqembi should only be covered to treat adult patients aged 50 years or older who have a clinical diagnosis of early AD with confirmed amyloid pathology using a validated method, and who are APOE4 noncarriers or heterozygotes. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Association Between Alzheimer Pathology, Sleep, and Cognition in Patients With Late-Onset Unexplained Epilepsy

44/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In individuals with LOUE, elevated plasma p-tau217 was associated with both cognitive impairment and disrupted sleep microarchitecture, with the most pronounced cognitive deficits observed in individuals with medication refractory epilepsy. +1 more finding

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Mitochondrial DNA copy number in neurodegenerative diseases: a global meta-analysis of 156 comparisons across 76 studies

16/100 ⚠ Preprint — not yet peer-reviewed How common it is bioRxiv

Key finding: Consequently, changes in mitochondrial DNA copy number (mtDNA-CN), the number of mtDNA genomes per cell or tissue sample, are associated with diseases ranging from cancer and obesity to psoriasis and all-cause mortality. +4 more findings

• Brain Biology

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

45/100 ✓ Peer-reviewed Disease mechanisms Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Key finding: Proteomics revealed widespread synaptic remodeling accompanied by disease-associated microglia, astrocyte-mediated excitotoxicity, and pyroptotic pathways. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

GLP-1-BASED THERAPIES BEYOND DIABETES: EMERGING CLINICAL APPLICATIONS AND FUTURE PERSPECTIVES

44/100 ✓ Peer-reviewed Drug development Archiv Euromedica

Key finding: Fifty-three sources were included. +1 more finding

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

The circadian system is affected by Alzheimer’s disease independently from amyloid beta deposits

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: The sleep architecture of APP/PS1 mice displayed significantly reduced rapid eye movement sleep (REM), associated with a reduced daily core body temperature amplitude and locomotor hyperactivity. +3 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Spanish grammaticality judgment task for neurodegenerative diseases: inflectional, transitivity, and word order comprehension in PPA and Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies medRxiv (preprint)

Key finding: Exploratory analyses revealed that short-term memory, working memory, and verbal semantics were differentially associated with sentence evaluation performance within and across groups. +1 more finding

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Genetic associations with EEG signatures in mild cognitive impairment: insights into Alzheimer's disease pathophysiology

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: Genome-wide genotypes were quality-controlled, imputed, functionally annotated (yielding 16,935 gene regions comprising 90,607 functional variants), and associated with latent EEG features using Bayesian reduced rank regression. +4 more findings

• Biomarkers
• Genetics
• Early Stage

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Although the neuropathology of the postnatal and adult DS brain has been widely described, it remains unclear how trisomy 21 alters early human neural and glial development. +3 more findings

• Down Syndrome
• Brain Biology

Scored 18 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Epilepsy and subsequent dementia in adults with down syndrome: a propensity score-matched cohort study using federated electronic health records

53/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Seizure

Key finding: Epilepsy was associated with higher subsequent recording of dementia and mortality over 2 years. +3 more findings

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Intelligence Breaks the System It Controls

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

Key finding: These findings show that the obstacle to safe clinical AI is not that clinicians and models need to cooperate better with the information they have.

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A biphasic astrocytic PTGDS trajectory marks a metabolic vulnerability stage in prodromal Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

Key finding: PTGDS followed a biphasic astrocytic trajectory with a statistically resolved donor-level inflection (quadratic term −2.27, p = 0.006; vertex at pseudo-progression score 0.47, bootstrap 95% confidence interval 0.32 to 0.53). +4 more findings

• Brain Biology
• Early Stage

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Sensorimotor Characterization of Alzheimer’s Disease Using Virtual Reaching and Catching Tasks

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

Key finding: Individuals with MCI and AD exhibit marked deficits in the performance and accuracy of upper-limb reaching and catching movements when assessed in a VR environment. +2 more findings

• Diagnosis

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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AI on Alzheimer Disease: Large-Scale Reproduction Shows the Field’s Hypotheses Cannot Be Distinguished on Common Data

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: Yet on common ground the camps did not differ in predictive capability, resolving onto a single brain-integrity axis. +4 more findings

• Digital Tools

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Association between Internet Use for Health Information and Self-reported Alzheimer’s Disease Diagnosis among Older Adults in the United States: Racial and Gender Disparities

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Research Square

Key finding: Internet use for health information was significantly associated with Alzheimer’s disease diagnosis. +2 more findings

• Health Equity
• Diagnosis

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Environmental Exposures and Brain Health Outcomes in Healthy Ageing: A Systematic Review

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv

Key finding: Of 2,496 records screened, 26 studies met eligibility, comprising >84,000 older adults across 10 countries: United States, South Korea, United Kingdom, France, Spain, Sweden, Netherlands, Taiwan, Germany, and Japan. +3 more findings

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Pre-dementia clinical trajectories associated with neuronal α-synuclein neuropathologic change: a retrospective cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials Research Square

Key finding: NSNC without intermediate or high ADNC was associated with the greatest motor burden. +2 more findings

• Brain Biology

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The effects of virtual reality and video conferencing on personal and relational well-being among older adults with cognitive impairments and their adult children: The Thrive randomized controlled trial

16/100 ⚠ Preprint — not yet peer-reviewed Clinical trials Research Square

Key finding: This stratified, unblinded, parallel-group randomized controlled trial tested a four-week virtual reality (VR) intervention ( Thrive ) designed to improve well-being for older adults with cognitive impairment and their adult children living at a distance, compared to an active video conferencing (VC) control. +3 more findings

• Clinical Trials
• Digital Tools

Scored 53 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Proof-of-Concept Graphene-Functionalised Embroidered Textile Biosensing Platform for Salivary Alzheimer's Disease Biomarker Detection

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: The rGO-coated electrodes demonstrated improved electrical stability and lower resistance variation compared with GO-coated electrodes, reflecting enhanced conductivity following chemical reduction. +1 more finding

• Biomarkers

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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